[Opiatergic mechanisms of cardioprotective and anti-arrhythmic effects of adaptation].
Explore the source record for details and available documents.
Adaptation, Physiological↗
Biomedical subjects
L A Maĭmeskulova
Publications and source records attributed to L A Maĭmeskulova.
[Mechanism of the anti-arrhythmic effect of Rhodiola rosea extract].
Explore the source record for details and available documents.
Animals↗
[Anti-arrhythmic effect of phytoadaptogens].
Repeated prophylactic administration of plant adaptogen preparations based on extracts from rhodiola, eleutherococcus, leuzea, and ginseng, produced a pronounced antiarrhythmic effect on the model of adrenal arrhythmia in animals. Preliminary opioid receptor block by naloxone reduced the protective effect of phytopreparations in the adapted animals. Intravenous and intracerebroventricular administration of naloxone (opioid receptor antagonist) showed that the anti-arrhythmic effect of rhodiola extract proceeds through the activation of both central and peripheral opioid receptors.
Adrenergic Agonists↗
[The participation of the mu-, delta- and kappa-opioid receptors in the realization of the anti-arrhythmia effect of Rhodiola rosea].
A course of the adaptogen extractum Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of mu-opiate receptors (OR) by naloxone (0.2 mg/kg) and delta-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of kappa-OR.
Adaptation, Physiological↗
[The anti-arrhythmia action of an extract of Rhodiola rosea and of n-tyrosol in models of experimental arrhythmias].
A daily 8-day course of Rhodiolae fluidum extract (1 ml/kg; ED50 = 0.43 ml/kg)--a preparation from the group of adaptogens caused a marked preventive antiarrhythmic effect on models of adrenaline and CaCl2-induced, but not acontine, arrhythmias. Aglycone--n-tyrosol demonstrated a lower antiarrhythmic activity (ED50 = 16 mg/kg) than that of Rhodiola extract.
Aconitine↗