Biomedical subjects
Publications and source records attributed to L A Maksimova.
A retrospective analysis of results of vagotomy for ulcer disease of the duodenum has revealed substantial dependence of incidence of postoperative complications on duodenogastric reflux.
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Results of histological, histochemical and electron-microscopy studies of puncture-biopsy specimens of the liver of 25 patients with alcoholic hepatitis are discussed. It is shown that acute alcoholic hepatitis develops, develops, as a rule against the background of steatosis and hepatocirrhosis as a result of the previous chronic consumption of alcohol. Lesions of the liver in this disease are of cholestatic character, which was due to the impairment of the metabolism of lipids, cholesterol and biliary acids under the effect of ethanol. The microscopic picture of alcoholic hepatitis is characterized by the presence of Mallory hyalin, intracellular congestion of the bile and predominance of neutrophilic leukocytes in the cell infiltrate. The characteristics make it possible to differentiate alcoholic hepatitis from viral one.
The conducted clinico-experimental study (an investigation of the functional and morphological state of the liver in impaired bile outflow) indicated different compensatory reactions. It is the authors' opinion that bile congestion in the liver is accompanied with proliferation of bile ducts; a damaging effect of bile components, in the first place bilious acids, is manifested in pericholangitis, periductal fibrosis and later in the development of biliary cirrhosis; alterations of the parenchyma occur secondarily also as a result of the toxic effect of bilous components and show a focal character.
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Metabolites excreted into culture medium by human skin fibroblasts have been studied by high resolution gas chromatography and mass spectrometry. Parameters for 29 metabolites have been obtained and 11 of them have been identified. Excreted metabolites reflect activity of certain metabolic processes in fibroblasts. Comparison of chromatographic and mass spectrometric parameters of cellular metabolites with the metabolites excreted with urine revealed that most metabolites excreted from fibroblasts differ from urine metabolites. The possibility for secondary transformation of cell metabolites in organism and specificity of metabolism in different tissues has been discussed.