Biomedical subjects
Publications and source records attributed to L A Paterson.
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
OBJECTIVE: To clarify what issues are important to stroke patients and their carers. To determine whether these issues change over time. DESIGN: Prospective study of consecutive patients admitted to hospital with a diagnosis of an acute stroke. Each participant had interviews at six and 24 months. In addition, a subgroup of these patients (consecutive discharges over a two-month period) were also seen at two weeks post discharge. SETTING AND SUBJECTS: Hospital-based cohort of stroke survivors. Interviewed in their own homes. MAIN OUTCOMES MEASURES: Documentation of the questions asked. RESULTS: At two weeks, six and 24 months, a median of three, two and three questions were asked by each patient respectively. Enquiries about basic aspects of stroke were common but diminished over time. Fear of recurrence was apparent at all three interview periods. Enquiries about the psychological sequelae of stroke became more prevalent at six and 24 months. At two years, 32% of respondents asked about concentration/memory difficulties with smaller numbers commenting on tiredness, depression and frustration. At two years, 18% of the sample were still uncertain of their chances of further recovery. CONCLUSIONS: Patients with stroke continue to have unanswered questions even two years after their stroke. The types of questions asked changed over time.