Biomedical subjects
Publications and source records attributed to L A Pokrovskaia.
Work associated with visual strain results in visual fatigue. Laser radiation in red part of spectrum relieves visual fatigue, activating reduction-oxidation thiol disulfide system in eyes.
Fluctuations of the thiol disulfide system were shown to be interrelated with changes in the ECG indices. Trimetazidine since it has antioxidant properties was found to be effective in patients with low thiol disulfide ratios. A single dose of 0.8 mg/kg of the body mass was shown to inhibit the appearance of stress-dependent ischemic symptoms during surgical procedures.
Changes of the thiol-disulfide balance and electrocardiographic indices were studied in ischemic heart disease patients undergoing operation stress. It was shown that the operative procedure resulted in a shift of the redox state to oxidation in the thiol-disulfide system, especially in its protein part. The revealed correlation between the value of the thiol-disulfide ratio and ECG changes attest to the significance of the state of the blood thiol-disulfide system for the assessment of the degree of ischemic alterations in the myocardium.
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Clinical and autopsy data presented in this paper illustrate difficulties arising in diagnosis of rheumatic heart disease (RHD) in elderly patients. RHD misdiagnosis is explained by unclear clinical symptoms, undone laboratory tests, concomitant diseases, misinterpretation of some objective indications (auscultatory symptoms, ECG). To diagnose acquired RHD earlier the physicians are recommended to refer their patients to ultrasound investigations of the heart.
Local and general reactions have been studied after subjecting a rabbit eye to dispersed helium-neon laser radiation, 8 x 10(-6) wt/cm-2, 10 min daily for 10 days. There were recorded increase of blood filling of the uveal tract of the eye, changes in the indices of systemic hemodynamics, systolic and diastolic pressure, stroke and minute volume of blood volume, activation of separate links of antioxidant system connected both with oxidation-reduction of thiol disulfide system and the functioning of antiperoxide enzymes. The activation of antioxidant system has a local character, the changes in the retina of the eye and pigmented epithelium is expressed stronger than in the peripheral blood. The results obtained speak about relationship between the stimulating effect of helium-neon laser radiation on the rabbit eye and activation of antioxidant system.
The study was undertaken to analyze the state of visual, cardiovascular and antioxidant systems along with peripheral blood exposed to laser emission with the wavelength of 10.6 mm and energetic exposure equal to that of threshold (21 J.cm2) and subthreshold (1/7 of the threshold value). Not only local but also general changes were detected. The cardiovascular and antioxidant systems were most sensitive to this type of exposure. The degree of changes was dose-dependent.
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The sensitivity to specific phages and morphological, physiological, and antigenic properties were compared among several strains of Bacillus thuringiensis isolated from insects inhabiting various geographical zones. All 43 cultures assigned to Bac. thuringiensis var. sotto and 198 among 170 cultures classed as Bac. thuringiensis var. dendrolimus were found to belong to Bac. thuringiensis var. dendrolimus. None of these cultures was resistant to its specific phage. The same was true of 22 studied cultures of Bac. thuringiensis var. galleriae. Only two among studied 45 cultures of Bac. thuringiensis var. thuringiensis were resistant to phages specific for this variety. Therefore, the abundance of variants resistant to specific phages in natural conditions differs among the varieties of Bac. thuringiensis. In most cases, cultures of the same variety of Bac. thuringiensis isolated from various insects inhabiting different geographical zones are identical by their sensitivity to specific phages and by other important characteristics.