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Biomedical subjects

L A Popova

Publications and source records attributed to L A Popova.

At least 19 recordsLinked to original sources
PubMed2006

[Evaluation of the course of chronic obstructive lung diseases according to the classifications of the European Respiratory Society and the Global Initiative on Chronic Obstructive Lung Disease].

In 91 patients with chronic obstructive lung disease (COLD), the severity of this disease according to the Classifications of the European Respiratory Society (ERS) and the Global Initiative on Chronic Obstructive Lung Disease (GOLD) was compared with that of pulmonary dysfunction according to the data of a comprehensive study, involving the determination of bronchial patency, lung volumes, capacities, and gas-exchange function. This follows that the ERS and GOLD classifications are to be positively appraised as they provide an eligible group of patients for clinical practice in terms of the severity of pulmonary dysfunction and that of COLD. However, the concomitant clinical use of both classifications cannot be regarded as justifiable due to that there are differences in the number of detectable grades (stages) of COLD and borderline (COLD differentiating grades (stages) values of EFV1). In this connection, both classifications have approximately equally significant merits and shortcomings and it is practically impossible to give preference to one of them as the best one. The optimal way out of the established situation is to develop a new (improved) classification of the severity of COLD on the bases of these two existing classifications.

Europe↗
PubMed2005

[Lung dysfunction in patients with severe chronic obstructive bronchitis].

VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TCL, TGV, RV, Raw, Rin, Rex, DLCO-SS, PaO2, and PaCO2 were determined in 36 patients with severe chronic obstructive lung disease (FEV1 < 50% of the normal value). All the patients were found to have impaired bronchial patency and changes in lung volumes and capacities; 83.3% of the patients had pulmonary gas exchange dysfunction. Impaired bronchial patency mainly appeared as decreased FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, Raw, Rin, Rex; altered lung volumes and capacities manifested by increased RV, TGV, and TLC, and by decreased VC and FVC; pulmonary gas exchange dysfunction showed up as lowered PaO2 and DLCO-SS, as decreased or increased PaCO2. The observed bronchial patency disorders varied from significant to severe; functional changes in lung volumes and capacities were mild to severe.

Adult↗
PubMed2004

[Lung dysfunction in patients with mild chronic obstructive bronchitis].

VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TCL, TGV, RV, Ravt, Riin, Rex, DLCO-SS, PaO2, and PaO2 were determined in 33 patients with mild chronic obstructive lung disease (FEV1 > 70% of the normal value). All the patients were found to have impaired bronchial patency; most (63.6%) patients had lung volume and capacity changes, almost half (45.5%) the patients had pulmonary gas exchange dysfunction. Impaired bronchial patency mainly appeared as decreased MEF50, MEF15, and FEV1/VC%; altered lung volumes and capacities manifested chiefly by increased RV and decreased VC; pulmonary gas exchange dysfunction showed up primarily as lowered PaO2. The magnitude of the observed functional changes was generally slight. MEF50, MEF75, FEV1/VC%, and VC dropped to 59-20 and 79-70% of the normal value, respectively. RV increased up to 142-196% of the normal value; PaO2 reduced up to 79-60% mm Hg.

Adult↗
PubMed2004

[Impaired lung function in patients with moderate chronic obstructive bronchitis].

VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, TLC, TGV, RV, Raw, Rin, Rex, DLCO-SS, paO2 and paCO2 were determined in 22 patients with moderate chronic obstructive bronchitis (FEV1, 79-50% of the normal value). All the patients were found to have impaired bronchial patency, 90.9% of the patients had lung volume and capacity changes; pulmonary gas exchange dysfunction was present in 72.7%. Bronchial patency impairments were manifested by a decrease in FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, and an increase in Raw, Rin, Rex. Changes in the lung volumes and capacities appeared as higher RV, TGV, TLC, lower VC and FVC. Pulmonary gas exchange dysfunction showed up as a reduction in pO2 and DLCO-SS a reduction and an increase in paCO2. The magnitude of the functional changes observed in most patients was low. Significant and pronounced disorders were seen in one third of the patients.

Adult↗
PubMed2002

[Long-term results of prolonged treatment in patients with fibrosing alveolitis (prophylactic medical examination)].

The results of a long-term (5-10 year) follow-up were studied in 109 patients with alveolitis, including 89 with EAA and 20 with IFA. A variety of treatments were applied. The predominant treatments were hormonal therapy supplemented by plasmapheresis, physiotherapy, oxygen therapy, etc. A follow-up of patients with alveolitis was made by 3 groups. Group 1 was compensated--Stage 0; Group 2, subcompensated--Stage II; Group 3, decompensated--Stage III. The control periods and scope of examinations were defined for each group. The Regulations governing the prophylactic medical examination of patients with alveolitis were worked out. Among patients with EAA, good results, such as improvement and stabilization of the process, were observed in 34.8% of cases, poor results, such as recurrences were in 53.6%, death rates were 3%. Among patients with IFA, good results were achieved in 15% of cases, recurrences and progression were in 10 and 30.7%, respectively, death rates were 40%.

Adjuvants, Immunologic↗
PubMed2002

[Dynamics of changes in lung function in patients with recurrent tuberculosis and ineffective primary treatment in intensive phase of controlled chemotherapy].

In 51 patients with recurrent tuberculosis and ineffective primary treatment in intensive controlled chemotherapy, VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, Pa02, PaCO2 were measured before, during, and after intensive controlled chemotherapy. Lung function improved in 51.0% of the patients and deteriorated in 19.6%. There was a combination of better and worse lung function in 9.8% of the examinees. The improvement of lung function was observed only during effective chemotherapy, its deterioration was seen mainly during ineffective chemotherapy, rarely during successful chemotherapy. The main cause of better lung function was the resolution of fresh inflammatory changes and that of worse lung function is the cicatricial transformation of lung tissue.

Adolescent↗
PubMed2001

[Significance of bronchospasm in the development of bronchial obstruction in lung diseases].

VC, FVC, FEV1/VC%, PEF, MEF25, MEF50, MEF75 were studied in 254 patients with lung diseases with bronchial obstruction before and after berotec and antrovent inhalation. Bronchospasm was detected in most patients with bronchial asthma, in a half with exogenous allergic alveolitis, in more than a third with chronic bronchitis and pulmonary tuberculosis, and in a fifth with pulmonary sarcoidosis. In most examinees with bronchospasm, the proportion of the latter in bronchial obstruction amounted to 61-100%.

Adolescent↗
PubMed2001

[The role of bronchospasm in the impaired bronchial permeability in sarcoidosis].

VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75 were registered in 24 sarcoidosis patients before and after inhalation of 1 dose of berotec and 1 dose of atrovent. Bronchospasm took place in 20.8% patients. Bronchospasm was the only cause of bronchial obstruction in 16.7%, one of the causes in 4.2%. Contribution of bronchospasm to development of bronchial obstruction was essential in all the examinees (91-100%).

Adult↗
PubMed2001

[Significance of bronchospasm in the development of bronchial obstruction in exogenous allergic alveolitis].

In 22 patients with exogenous allergic alveolitis, VC, FVC, FEV1/VC%, PEF, MEF25, MEF50, MEF75 were determined before and after inhalation of berotec in 1 dose and antrovent in 1 dose. Bronchospasm was detected in 50% of patients. Bronchial spasm was the sole cause of bronchial obstruction in 18.2% of patients and a cause of this disorder in 31.8%. The contribution of bronchospasm to the development of bronchial obstruction was decisive in most patients. In 42% of patients, the proportion of the former in bronchial obstruction amounted to 61-100%.

Adult↗
PubMed2001

[Changes in lung function in patients with newly-diagnosed tuberculosis during treatment with short courses of controlled drug therapy].

In 54 new cases of tuberculosis, VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, PaO2, PaCO2 were measured before, during, and after a short-term intensive controlled chemotherapy. Lung function improved in 57.4% of patients and deteriorated in 22.2%. There was a combination of better and worse lung function in 7.4%. The direction of functional changes depended on the form of tuberculosis, the extent of a tuberculous process, the duration and efficiency of chemotherapy.

Adolescent↗
PubMed2000

[Pulmonary function changes induced by bronchial asthma in children, teenagers and adults].

The study has established that pulmonary dysfunctions in bronchial asthma are less marked in children and teenagers than in adults. The magnitude of pulmonary dysfunctions are chiefly determined by the severity of bronchial asthma. There was a less close relationship of pulmonary function to the duration of bronchial asthma. There was no association of the severity of pulmonary dysfunctions with the duration of bronchial asthma.

Adolescent↗
PubMed1999

[Role of bronchospasm in impairment of bronchial permeability in bronchial asthma in attack-free period].

Lung capacity (LC), functional lung capacity (FLC), FEV1, FEV1/LC%, CO25, CO50, CO75 were measured in 56 patients with bronchial asthma in attach-free period before and after inhalation of one-dose berotec and one-dose atrovent. Bronchospasm was registered in 66% of the patients. It was the only cause of bronchial obstruction in 12% of the patients and one of the causes in 54% of them. Contribution of the bronchospasm to development of bronchial obstruction was, as a rule, dominating. This contribution reached 81-100% in 60% of the patients.

Administration, Inhalation↗
PubMed1998

[Sanology as a science].

The paper focuses on the history and sources of origin of sanology as science, with its brief characterization being given, relating to such items as definition, object and subject of investigation, methodological approaches and tasks, with special emphasis being placed on the significance of sanology in the elaboration of general theory of medicine.

Health↗
PubMed1997

[Pulmonary elastic pressure as an indicator of lung tissue morpho-functional restructure].

The examination of 100 patients with tuberculosis and exogenous allergic alveolitis showed it expedient to study pulmonary elastic pressure in patients without or with or X-ray signs of pneumosclerosis and pulmonary emphysema. Its exploration could diagnose initial (pre-X-ray) manifestations of pneumosclerosis and pulmonary emphysema in the former patients and specify the extent and relatively significant manifestations of these abnormalities at the subsequent (X-ray detected) stages in the others.

Adult↗
PubMed1993

[The immune protection of the gastroduodenal area after the surgical treatment of duodenal peptic ulcer].

The complex study of the indices of local immune and natural resistance in the parietal mucus of the gastroduodenal zone and general immunity in 174 patients with duodenal ulcer disease before and after surgical treatment was performed. Pronounced suppression of local immunity, presence of autoimmune processes having influence on its indices were noted. After the organ-preserving operations with an ulcer excision, the immune indices restored more rapidly than after gastric resection and vagotomy without an ulcer excision.

Adolescent↗
PubMed1993

[Effectiveness of chemoprevention of tuberculosis in adolescents with hyperreactivity to the Mantoux test with 2 TU in tuberculin electrophoresis].

It is demonstrated that tuberculin electrophoresis in chemoprophylaxix for M.tuberculosis infection in adolescents with a marked of hyperergic reaction to the Mantoux test (2TU) contributes to enhancement of nonspecific immunological reactivity, to a decline in immunospecific reactions, and reduction in the response to the Mantoux test (2TU).

Adolescent↗