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Biomedical subjects

L A Samorodinova

Publications and source records attributed to L A Samorodinova.

17 recordsLinked to original sources
PubMed1993

[Tumor necrosis factor in acute inflammatory diseases of the internal genitalia].

Blood serum cytotoxic activity of women with acute inflammatory diseases of the internal genitals was studied over the course of combined therapy, including immunomodulators, making use of target cells sensitive to the tumor necrosis factor (TNF). The levels of TNF activities varied within a wide range at the moment of the patients' admittance to hospital. TNF levels were high in the majority of patients or were increasing over the course of treatment. A low cytotoxic activity or its stable level over the course of treatment may be explained by a reduction of the immunocompetent cells functional activity.

Acute Disease↗
PubMed1991

[Correction with T-activin of secondary immunodeficiency in inflammatory diseases of female internal genital organs].

A clinicoimmunological examination was performed in 70 patients with acute inflammatory disease of internal genitalia. All the patients received a multimodality anti-inflammatory therapy. They were divided into 2 groups: 1) 30 patients taking ++T-activin as an adjuvant and 2) 40 patients untreated with it. T and B lymphocytes were measured by current cytofluorometry+ by means of monoclonal antibodies and the rosette-forming method. A subpopulation analysis of the T-cell immune system revealed lower T-helper count and decreased immunoregulatory index. ++T-activin used in the multimodality therapy for acute inflammatory diseases of internal genitalia improved the qualitative parameters of regulatory T-cell subpopulations, returned T and B lymphocytes to normal levels and elevated IgG concentrations.

Acute Disease↗
PubMed1987

Location of placenta and clinical course of labour.

The results of studies on 2396 women are presented. Relations were found between location of placenta and 'ripeness' of uterine cervix, duration of labour, prognostic value of intrauterine pressure, complications of the third stage, fate of the newborn and success of induction of labour. The authors arrived at the conclusion that attachment of the placenta to the fundus uteri may be considered an unfavourable location causing an increase in the number of different deviations from normal labour.

Apgar Score↗
PubMed1979

[Effect of progesterone and estrogens on the state of the hypothalamo-hypophyseal neurosecretory system in pregnancy and labor].

Morphofunctional state of the hypothalamo-hypophyseal neurosecretory system was studied in rats at late stages of pregnancy. No special differences both in function of the supraoptical and praventricular nuclei, and in the hypophysis of intact and pregnant rats at administration of progesterone were noted. When estrogenes were administered to pregnant animals, a sharp increase in functioning of the supraoptic and especially of the paraventricular nuclei was noted. The greatest activity of the supraoptic nucleus was observed at delivery that could be resulted from a stress reaction to pain.

Animals↗