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Biomedical subjects

L A Solberg

Publications and source records attributed to L A Solberg.

At least 73 records · Page 4Linked to original sources
PubMed1982

Changes in the nasal mucosa of furniture workers. A pilot study.

The present study was carried out in order to evaluate whether precancerous lesions could be detected in the nasal mucosa of furniture workers. Histological examination of nasal biopsies from 113 workers (103 active and 10 retired) and 54 referents was performed. The histological sections were evaluated blindly according to a numerical classification scale, and the results were compared, by means of multiple regression analysis, to age, type and duration of exposure to wood dust, smoking habits, nasal allergy, and rhinoscopic findings. Nasal stenosis and mechanical wood preparation were significantly related to the histological findings by the partial correlation coefficients. Fourteen cases (12%) of dysplasia were found among the furniture workers, preferentially among those performing mechanical wood preparation, and among the referents there was one (2%). The evaluation of the importance of exposure to dust of individual types of wood was not possible. Nasal epithelial dysplasia should probably be interpreted as a preneoplastic lesion and may be of significance in the pathogenesis of nasal adenocarcinoma. Standard nasal biopsies appear to be valuable in identifying groups of persons with an increased incidence of nasal carcinoma.

Adult↗
PubMed1980

Doxorubicin-enhanced skin reaction after whole-body electron-beam irradiation for leukemia cutis.

This is the first report of doxorubicin (Adriamycin) interacting with whole-body electro-beam irradiation to produce generalized toxic epidermal necrolysis. The patient was a 32-year-old woman with acute myelomonocytic leukemia and leukemia cutis. The severe dermatitis obscured clinical recognition of concomitant pseudomembranous colitis and contributed to the patient's death during management of toxic megacolon. Suggestions are made for minimizing this occurrence in future patients treated in a similar fashion.

Adult↗
PubMed1980

Morphometric light and electron microscopic studies of histopathological changes in nasal mucosa of nickel workers.

Biopsies of nasal epithelium consisting of metaplasia (stratified cuboid epithelium, mixed stratified cuboid/stratified squamous epithelium and squamous epithelium), dysplasia and carcinoma, were the subjects of morphometric analysis using semithin sections of plastic embedded material. Use of a semiautomatic device for image analysis (MOP, AMO3, Kontron) facilitated the workload considerably but not at the expense of reliability. The measurements were restricted to the basal layer. The preliminary study consists of scanning and transmission electron microscopy besides morphometry. The most interesting electron microscopic finding was a significant reduction in foldings of the surface of the plasma membrane in dysplasia with a nearly complete loss in carcinoma and an increase of desmosomes in dysplasia. The most conspicuous light microscopic finding was an increase in the cell size with largest values in dysplasia (162 +/- 16 micrometer 2) and an unchanged nuclear/cytoplasmic ratio for the different types of metaplasia of 0.28 in contrast to dysplasia and carcinoma of 0.31 and 0.51 respectively. Alterations of the karyoplasm consisted of a conspicuous, gradual increase in the percentage of nuclei containing nucleoli, which was nearly 100% in carcinoma. The nucleoli fraction per nuclei was 7.6% in dysplasia, which was a 2 or 1.5 times increase compared to stratified cuboid epithelium or carcinoma respectively. This increase was mainly the consequence of an enlargement of the average nucleoli size which was 2 or 3 times higher in atypia (9.3 +/- 1.4 micrometer 2) than in stratified cuboid epithelium and carcinoma respectively. Further work is in progress to enlarge the number of analyzed cases and especially to quantify the ultrastructural alterations.

Cell Membrane↗
PubMed1979

Histopathologic changes of nasal mucosa in nickel workers: a pilot study.

Histologic examination of standard biopsy specimens from nasal mucosa were performed on 98 former and present employees at a nickel refinery and 61 controls. Histologic characteristics of the epithelium were graded blindly according to a point score table. The histologic scores were compared to certain epidemiologic data, such as the degree and duration of nickel exposure, duration of industrial work without nickel exposure, age, and smoking habits. High histologic scores were correlated to high nickel exposure, to the duration of this exposure, to age, and to industrial work not involved with nickel. One person with nasal carcinoma was detected in the nickel-exposed group. During the investigation period, three additional nasal carcinomas in former nickel workers were discovered and later included in the study. Furthermore, 18 cases of epithelial dysplasia were found in the nickelexposed group, but none among the controls. The cases with nasal carcinomas were or had been working with processes that gave an estimated high nickel dust exposure. All the individuals with epithelial dysplasia were nickel process workers.

Adult↗
PubMed1979

Histopathological changes of the nasal mucosa in active and retired nickel workers.

Histological examinations were made on nasal biopsy specimens from the middle turbinate in 318 active and 15 retired nickel workers and in 57 controls, to study the prevalence of nasal carcinoma or possible precancerous mucosal changes in nickel-exposed individuals. The histopathological changes were evaluated according to a point-score scale, and the results were correlated to age, smoking habits, duration and type of nickel exposure and to nickel concentrations in nasal mucosa, plasma and urine. The explanatory values of these factors on the histopathology were estimated by stepwise multiple regression analysis. Two nickel workers from the roasting/smelting department (0.6%), both employed 28 years at the plant, had nasal carcinoma. Epithelial dysplasia was found in about 12% of active and 47% of retired nickel workers. One of the controls, a male carpenter, had dysplasia. These histopathological changes may be precancerous lesions, as they are almost exclusively found in active and retired nickel workers with enhanced risk of nasal carcinoma. Loss of respiratory epithelium and development of squamous epithelium were regarded as unspecific histopathological changes. These changes were seen in all groups, even though in significantly higher incidence in the nickel-exposed groups. Duration of nickel exposure, type of nickel-refining work and tobacco consumption were the independent variable that, taken altogether, had the highest explanatory values for the histopathological changes.

Adult↗