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Biomedical subjects

L A Williams

Publications and source records attributed to L A Williams.

12 recordsLinked to original sources
PubMed1979

Heterogeneity of delta-crystallins of the embryonic mallard lens. Correlation between subunit compositions and isoelectric points.

delta-Crystallins from the lenses of embryonic mallards (Anas platyrhynchos) were analyzed with respect to native and subunit molecular weight, subunit composition, and isoelectric point. NaDodSO4-urea-polyacrylamide gel electrophoresis showed that unfractionated mallard delta-crystallins are composed of approximately equal amounts of subunits with molecular weights near 47 000 and 48 000. Agarose gel chromatography showed that the embryonic mallard delta-crystallins have native molecular weights slightly less than 200 000. Thus, embryonic mallard delta-crystallins appear to be tetramers. Five major and nine minor delta-crystallins were resolved by isoelectric focusing. The five predominant delta-crystallins each cross-reacted with antichick delta-crystallin antiserum, and each had a different proportion of the larger and smaller subunits, indicating a direct relationship between the isoelectric point and the subunit composition. The presence of numerous, minor species of native delta-crystallins with different isoelectric points suggested that the subunits possess charge heteogeneity as well as size heterogeneity.

Animals↗
PubMed1979

Peritoneal cannulography.

Peritoneal dialysis is a simple effective treatment for patients with some forms of renal failure, poisoning and fluid and electrolyte imbalance. There are several well-recognised complications. Common amongst these are malinsertion and positioning of the cannulae, perforation of visci and partial blockage of the cannula by debris. A simple technique of cannulography is described whereby the diagnosis of some of these conditions can be readily achieved.

Adult↗
PubMed1976

Pelvic exenteration as palliation of malignant disease.

It has been traditional to exclude patients with radiation-recurrent carcinoma of the uterine cervix or other pelvic neoplasms, incapacitating pelvic pain, postirradiation fistulas, hemorrhage, or malodorous draining tumor necrosis from pelvic exenteration if cure of the malignant disease is not achievable. This negative attitude is a direct result of the reported high morbidity, prohibitive mortality, and low salvage rate previously associated with pelvic exenteration, the only acceptable surgical approach to these diseases. A recent experience with eighteen patients who underwent pelvic exenteration for advanced primary or recurrent carcinoma of the cervix, urinary bladder, or rectum has led us to challenge several traditional concepts regarding this operative procedure. We have observed but one operative death and our morbidity has been minimal. This may reflect our belief that an aggressive pelvic lymphadenectomy in those patients with direct visceral involvement from radiation-recurrent carcinoma of the pelvic viscera is not advantageous since no significant survival has ever been documented for patients with pathologic visceral involvement and positive lymph nodes. In addition, significant morbidity has always been associated directly with pelvic lymphadenectomy in the irradiated pelvis, and elimination of this phase of the operation in selected patients with radiation-recurrent carcinoma is indicated. Moreover, the considerable decrease in morbidity and the minimal mortality observed have led us to adopt a very liberal attitude toward preoperative selection criteria, and we regularly now use pelvic exenteration not only for cure but as intentional palliation in selected patients. We strongly believe that elimination of pain, fistulas, pelvic sepsis, hemorrhage, and malodorous areas of tumor necrosis are important for improving the quality of life for both the patient and family.

Aged↗
PubMed1976

Shunt blockage in hydrocephalic children: the use of the valvogram.

Shunt blockage in valve-dependent hydrocephalic children is not always recognised, as symptoms may be non-specific and signs inconclusive. Valvography is a simple, easily interpreted technique for the investigation of shunt patency in children with Spitz Holter values in the shunt system. The technique affords a simple, rapid method of demonstrating patency at the cardiac end of the shunt. Fifty-one valvograms have been performed in 36 children. In 25 obstruction of the lower end was demonstrated. The unreliability of some associated signs is demonstrated. No serious complications have been observed and the technique has proved an invaluable addition to the practical management of these children.

Catheterization↗
PubMed1975

The role of a normal lens in Wolffian lens regeneration.

The mid-ventral third of the iris was excised from 61 adult Notophthalmus viridescens hosts, and the mid-dorsal third of the iris from donor eyes was implanted in its place. After the iris healed and the host lens was removed, two lens regenerates developed, one from the host and one from the transplanted iris. The host regenerate was removed 53-91 days after the first lentectomy. Animals were sacrificed 1-40 days after the second lentectomy. A lens developed from the host dorsal iris IN THE PRESENCE OF A NORMAL REGENERATED LENS IN 75% OF THE CASES. A large space was present between the transplant derived lens and host iris for approximately 20 days after the removal of the host lens at lentectomy 2. Stimulatory factor(s) from the neural retina could reach the competent iris through this space, inducing it to regenerate a lens. Therefore, contact between the normal lens and iris probably acts to prevent lens regeneration. In other experiments, variable amounts of neural retina from either adult or larval donors were implanted into the anterior chamber of adult newt eyes in which the lens, iris and neural retina remained in their normal relationships. Implants also contained dorsal iris, ventral iris, or no iris at all. Competent iris tissue, stimulated by the implanted retina, showed only early stages of lens regeneration, but larval retina effected a greater response than adult retina. This limited response may result from the small amount of retina in the implant, a deficiency in retinal stimulus, or a competition for the retinal factor(s) by competent iris tissues.

Animals↗
PubMed1975

The use of the valvogram for the detection of shunt blockage in hydrocephalic children.

Valvography is a simple, safe, rapid, easily interpreted technique for the investigation of possible blockage of the distal end of the shunt system containing a Spitz-Holter valve. Details are presented of 64 investigations in 46 children, 30 of which demonstrated distal obstruction of the shunt system. The unreliability of some physical signs is discussed. No serious complications were encountered and the procedure has proved to be a valuable addition to the practical management of shunt-dependent children.

Cerebrospinal Fluid Shunts↗
PubMedDate not supplied

An unusual cause of knee locking: a case report.

Intra-articular tumors of the knee joint causing intermittent locking are extremely rare. A 39-year-old woman with the complaint of joint locking had a pedunculated intra-articular mass and nodular synovitis.

Adult↗