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Biomedical subjects

L Abet

Publications and source records attributed to L Abet.

At least 19 recordsLinked to original sources

[The accuracy of the imaging procedures (sonography, MRT, CT, angio-CT,nuclear medicine) in characterizing liver tumors].

In a prospective study, an attempt was made to determine the specificity of various imaging methods for defining tumours of the liver rather than their ability to demonstrate them. It was based on 130 patients with histologically confirmed lesions (33 haemangiomas, 17 FNH, 4 hepatocellular adenomas, 28 HCC, 36 adenocarcinoma metastases). The methods were MRT (130 cases), sonography (119), CT (122), dynamic arterial angio-CT (15), 99TC-EHIDA or blood pool scintigraphy (4 FNH, haemangiomas, HCC, 44 cases). MRT showed somewhat better results (accuracy 80%) than CT (73%) and angio-CT (73%) in demonstrating the type of lesion. The results of scintigraphy (53%) and sonography (69%) were rather worse. The range of accuracy for MRT, CT and sonography varied from 94% (haemangiomas with MRT) to 47% (FNH with sonography).

Biopsy

[Diagnostic imaging in female infertility and sterility--desiderata and reality].

For medical imaging in the pelvic region in female infertility/sterility several methods of investigation are available. Risk/benefit-considerations of the mentioned methods lead to a diagnostic gold-standard: Hysterosalpingography, laparoscopy, laparotomy. Hysteroscopy and sonography can be employed facultatively after hysterosalpingography.

Diagnostic Imaging

[The normal fetal intestinal tract in correlation to gestational age. An amniofetography study].

Amniofetography represents an adequate method to study prenatally the fetal gastrointestinal tract in utero. In 108 pregnancies without fetal intestinal anomalies, the course of intestinal growth with regard to the lumen of certain parts of intestine has been analyzed. The results agree with those of other authors using sonography to study the intrauterine development of fetal intestinal tract. The demonstrated kinetics of contrast media passage through the gastrointestinal tract, following its intra-amnion application, contribute the knowledge of normal fetal physiology.

Amnion

[Ultrasound diagnosis of severe fetal abnormalities].

Reported in this paper is a case of premature termination of pregnancy in the 29th week because of sonographically diagnosed multiple malformations of the fetus. Holoprosencephaly, omphalocele, polyspleny syndrome, double-outlet right ventricle, and several skeletal malformations were established by pathologico-anatomic investigations. Possible correlation between these malformations are discussed in some details.

Abnormalities, Multiple

[Results of invasive and pharmacosonographic studies in pregnancy (I)].

In prenatal diagnosis besides radiographic methods there is a growing trend towards the use of invasive diagnostic techniques. These techniques have proved to be suitable for early detection of genetically determined conditions, diseases, and malformations of different origin. Invasive examination techniques were applied to 1.104 cases of prenatal diagnosis at Humboldt-University, Berlin, School of Medicine (Charité), Department of Gynaecology and Obstetrics, from January 1st, 1985, up to September 30th, 1987. In this paper importance and possible applications of these methods have been reported.

Amniocentesis

[Results of invasive and pharmacosonographic studies in pregnancy (II: Amniofetography)].

Prenatal diagnosis of fetal diseases and malformations, using invasive techniques is outlined in this paper. The value of amniofetography under present conditions is discussed together with the use of drugs both isolated and in conjunction with fill-up of the amniotic cavity. Indications for puncture of fluid-filled body cavities, with reference being made to patients looked after at the Humboldt-University Berlin, School of Medicine (Charité), Department of Gynaecology and Obstetrics, from 1985 up to 1987, are reported, too.

Congenital Abnormalities

[Perinatal medicine study group. Diagnosis and therapy of ventral schistasis].

Reported in this paper are twelve cases of ventral schistasis transferred for cooperative prenatal assessment, diagnosis, and therapy to the Berlin Charité Hospital of Gynaecology and Obstetrics in 1985 and 1986. Concomitant malformations were recorded from eight in ten omphaloceles. Three of these children were delivered on full term by spontaneous parturition or caesarean section. They were surgically treated immediately after birth. Gastroschisis was recorded from two pregnancies with ventral schistasis. No generally valid recommendation can be given for approach to ventral schistasis. The approach should rather be interdisciplinary and should be preceded by careful diagnosis. Parents should be involved in decision-making.

Abdominal Muscles

[Modification of the spectrum of neonatal surgery by prenatal diagnosis].

Expansion of prenatal diagnosis will alter the spectrum of neonatal surgery. The ethos of the medical profession calls for decision in favour of the mother, whenever evidence can be produced to the effect that a severely damaged or nonviable foetus may endanger the health of the pregnant woman. Humanistically and legally warranted termination of pregnancy in such cases will reduce the number of severely malformed newborns on whom nothing can be done but palliative treatment. Early detection of foetal diseases will enable, on the other hand, well-timed preparation of acutely necessary life-saving interventions and will bring down the rate of emergency operations on newborns.

Amniocentesis

[Is Teflon treatment of female urinary incontinence still justified?].

An analysis is made in this paper of therapeutic results obtained at Charité Berlin from 14 cases of pure stress incontinence and 6 cases of combined stress-urge incontinence, with reference being made to general benefits and setbacks of transurethral Teflon injection to cope with female urinary incontinence. Five women underwent teflon therapy as the first operation performed on them. Seven women had had one operation before and the rest more than one. Continence was restored in 6 patients (30 per cent), and 3 patients (15 per cent) were improved. The presurgical situation was of minor influence. The definite result was outlined as early as three months from surgery. Urodynamically, Teflon had a favourable impact primarily on functional urethral length and on the stress quotient. However, elevation of the bladder base was radiographically detectable in less numerous cases. Only partial agreement was found to exist between objectivated improvement and subjectively perceived and reported therapeutic results, with falsely positive and falsely negative findings occurring with equal frequency. Micturition was insubstantially impaired by Teflon. However, it should be adopted as a matter of principle that in future teflon should no longer be applied to women for urinary incontinence unless conservative therapy or other surgical incontinence techniques must be skipped for whatever reasons and unless no more effective sphincter substitute is available.

Adult

[Urodynamic and roentgenologic findings before and following complex physical therapy of urinary incontinence in the female].

In 42 patients complaints following therapy have been correlated to the pretherapeutic urodynamic findings and in 58 patients pre- and posttherapeutic urometric and X-ray findings have been compared independent from subjective result in oder to have objective parameters for the effectivity of conservative treatment of urinary incontinence. The best results could be achieved, if in the starting urometry the pressure transmission was bad and the dosing pressure of the urethra in rest adequate to the age. In analogy about identic urethral closing pressure in rest, but significant increase of the functional urethral length and a better pressure transmission in a sitting position could be found. Good results of conservative treatment on urge incontinence symptomatology could be derived from increasing bladder capacity and compliance. Against it a posttherapeutic increase of urinary incontinence signs by training-effects of exercise therapy has to be stated in the comparison of X-rays. Altogether the high rate of 63 per cent curing and 20 per cent improvement could not be detached sufficiently by urometric and radiography findings. This discrepancy has been discussed.

Female

Serum prolactin levels before and after galactography in patients with pathological nipple discharge.

Serum prolactin levels were determined in 25 women who underwent galactography on account of pathological nipple discharge. The test samples were obtained immediately before galactography as well as 5, 10, 15 and 30 minutes after. There was no significant change in serum prolactin levels following galactography. In 2 cases out of 25, the basal level of prolactin was well above normal while in 1 case it was below normal. Those three were cases of galactorrhea. The clinical aspect of pathological nipple discharge did not correlate with serum prolactin levels, and galactorrhea would appear to be compatible with serum prolactin levels below normal.

Adult

[New aspects of the Heidenreich and Beck perfusion method in urodynamics. I: Practical experience with a complex urodynamic work station].

122 patients with urinary incontinence of all degrees and 32 controls are investigated by means of a complex urodynamic unit constructed by the authors. Essential part is a robust selfmade three-canal-catheter of heatsealed angiographic material with an external diameter of 10 Charr., which undamagedly can be used at least forty times. The unit enables to do cystometries and simultaneous cystourethrotonometries with electromyography of pelvic floor and mictiometries. The investigations are possible at a normal expense in lying or sitting and all intermediate positions. Many urometric parameters had been determined with aid of perfusion uromanometry according to the principle of Heidenreich and Beck. New combinations had been elaborated. The functional length of urethra in stress profile, the maximal urethral closing pressure, the electronically registered urethral closure pressure, the depression factor and the stress quotient are of special importance. By means of these criteria the qualification of the apparently old fashioned perfsuion uromanometry for a modern urodynamic diagnosis could be demonstrated. The results are compared with those obtained with microtransducer technique.

Female

[Sonographic demonstration of intrafetal cysts and their differential diagnosis].

By high dissolvent power ultrasound equipments it is possible to perceive intrafetal malformations of organs in the second trimester of pregnancy already. Cystic abdominal tumours differential diagnostically are scarcely to be identified by ultrasound only. Their origin mostly is the urogenital system. Even monstrous findings don't allow a prognose of the further development. Additional procedure, e.g. puncture of the cysts by ultrasound sight are necessary for diagnose.

Abnormalities, Multiple

[Double-balloon urethrography in the female].

76 women with pains in the lower efferent urinary tract were urethrographically examined by the double balloon method according to Davis and Cian. The morphological changes registered were correlated with anamnestic, clinical and urodynamic findings and the following indications were derived for this X-ray examination of the female urethra: differential diagnosis between suburethral tumour and urethral diverticulum, recidive infections of the urinary tract, urethral syndrome, uromanometrically proved functional disturbances in the region of the bladder and urethra, painful catheterism and suspicion of urethrovaginal fistula.

Adult

[New aspects of the Heidenreich and Beck perfusion method in urodynamics. II: Effect of examination position on parameters of urethral pressure profile].

The perfusion urethrotonometry was used in this study in 34 patients both in lying and upright position as paired comparisons. The following problems could be solved: 1. Using the complex urodynamic unit of the authors examinations are possible in vertical position successfully. 2. The urethral pressure profiles are equivalent qualitatively in both examination positions. 3. The analysis of the profiles of both positions on principles demonstrates the same valuation. In case of incontinence the relevant parameters for diagnosis (functional length of urethra in stress profile, electronically registered urethral closure pressure in stressful situation, transmission and depression factor and stress quotient) show clearer in the upright position than in the lying one. In continent women the change of position has no significant influence. If the criteria in lying position are not well defined, the urethral pressure profile in upright position should be done as additional examination.

Female