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Biomedical subjects

L Albright

Publications and source records attributed to L Albright.

At least 19 recordsLinked to original sources

Acting, behaving, and the selfless basis of metaperception.

The desire to create a particular impression of oneself to others is a fundamental interpersonal motive that should be followed by an assessment of the success of the self-presentation. The authors integrate the areas of self-presentation and metaperception in the present research by assigning participants to enact roles during 2 dyadic interactions and measuring the actors' metaperceptions and their partners' trait judgments. They found a high level of accuracy in actors' metaperceptions but no accuracy in partners' trait judgments of the actors. Instead, partners' trait judgments corresponded closely to the actors interpersonal behavior, indicating that there was little or no "personality leakage" in the actors' behavior. Random assignment to role created a situation in which private self was uncorrelated with public self. Results indicate that actors were able to disregard their self-concepts when determining the impressions they created.

Affect↗

Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation.

PURPOSE: To evaluate prospectively the effects on survival, relapse-free survival, and patterns of relapse of reduced-dose (23.4 Gy in 13 fractions) compared with standard-dose (36 Gy in 20 fractions) neuraxis irradiation in patients 3 to 21 years of age with low-stage medulloblastoma, minimal postoperative residual disease, and no evidence of neuraxis disease. PATIENTS AND METHODS: The Pediatric Oncology Group and Children's Cancer Group randomized 126 patients to the study. All patients received posterior fossa irradiation to a total dose of 54 Gy in addition to the neuraxis treatment. Patients were staged postoperatively with contrast-enhanced cranial computed tomography, myelography, and CSF cytology. Of the registered patients, 38 were ineligible. RESULTS: The planned interim analysis that resulted in closure of the protocol showed that patients randomized to the reduced neuraxis treatment had increased frequency of relapse. In the final analysis, eligible patients receiving standard-dose neuraxis irradiation had 67% event-free survival (EFS) at 5 years (SE = 7.4%), whereas eligible patients receiving reduced-dose neuraxis irradiation had 52% event-free survival at 5 years (SE = 7.7%) (P =.080). At 8 years, the respective EFS proportions were also 67% (SE = 8.8%) and 52% (SE = 11%) (P =.141). These data confirm the original one-sided conclusions but suggest that differences are less marked with time. CONCLUSION: Reduced-dose neuraxis irradiation (23.4 Gy) is associated with increased risk of early relapse, early isolated neuraxis relapse, and lower 5-year EFS and overall survival than standard irradiation (36 Gy). The 5-year EFS for patients receiving standard-dose irradiation is suboptimal, and improved techniques and/or therapies are needed to improve ultimate outcome. Chemotherapy may contribute to this improvement.

Adolescent↗

Self-observation of social behavior and metaperception.

In 3 experiments (Ns = 68, 72, and 101) the authors tested the hypothesis that the opportunity to observe oneself in social interaction increases the accuracy of metaperception (prediction of others' social judgments of oneself). Small groups were videotaped during a decision-making task, after which group members judged each other's social anxiety. Participants watched either the videotape of their group's interaction or a videotape of another group's interaction. After watching the videotape, participants predicted how they were judged by each member of the group. Results from the 3 experiments confirmed the hypothesis that self-observation increases the accuracy of metaperception. Presumably, self-observation provides objective information about one's behavior, which increases the ability to determine how one is judged by others, assuming self and others share meaning systems.

Anxiety↗

Percutaneous gastrostomy tube placement in patients with ventriculoperitoneal shunts.

OBJECTIVE: The purpose of this study is to determine the risk of CNS and/or peritoneal infection in children with ventriculoperitoneal shunts in whom a percutaneous gastrostomy tube is placed. MATERIALS AND METHODS: We placed 205 gastrostomy or gastrojejunostomy tubes from January of 1991 to December 1996. Twenty-three patients (10 boys, 13 girls) had ventriculoperitoneal shunts at the time of placement. All shunts were placed at least 1 month prior to placement of the gastrostomy tube. The patients ranged in age from 8 months to 16 years with a mean age of 6 years, 9 months. Patient weight ranged from 2 kg to 60 kg. All 23 children required long-term nutritional support due to severe neurologic impairment. No prophylactic antibiotics were given prior to the procedure. Of the patients, 21/23 had a 14-F Sacks-Vine gastrostomy tube with a fixed terminal retention device inserted, using percutaneous fluoroscopic antegrade technique. Two of the 23 patients had a Ross 14-F Flexi-flo gastrostomy tube which required a retrograde technique due to a small caliber esophagus in these children. RESULTS: All 23 children had technically successful placements of percutaneous gastrostomy (7) or gastrojejunostomy (16) tubes. Of the children, 21/23 (91%) had no complications from the procedure. Two of 23 (9%) patients demonstrated signs of peritonitis after placement of their gastrostomy tubes and subsequently had shunt infections. In both, children CSF culture grew gram-positive cocci. The antegrade technique was used in both children who developed peritonitis. CONCLUSION: Our study indicates children with ventriculoperitoneal shunts who undergo percutaneous gastrostomy are at greater risk for infection and subsequent shunt malfunction. Therefore, we recommend prophylactic antibiotic therapy to cover for skin and oral flora.

Adolescent↗

Interpersonal perception and metaperception in nonoverlapping social groups.

Consensus, self-other agreement, and meta-accuracy were studied within and across nonoverlapping social groups. Thirty-one target persons were judged on the Big Five factors by 9 informants: 3 family members, 3 friends, and 3 coworkers. Although well acquainted within groups, informants were unacquainted between groups. A social relations analysis conducted within each social group showed reliable consensus on the Big Five personality factors. A model specified to estimate the consistency of a target person's effect on perceptions by others across social groups showed weaker agreement across groups. That is, targets were perceived consensually within groups, but these consensual perceptions differed between groups. The data suggest that personality and identity are context specific; however, there was some evidence of agreement in perceptions across groups.

Adult↗

Cross-cultural consensus in personality judgments.

Building on recent research demonstrating consensus and accuracy in interpersonal perception based on minimal information, the present studies examined American and Chinese participants' within- and cross-cultural judgments. In Study 1, the authors used the zero-acquaintance paradigm in the People's Republic of China and found consensus on all personality dimensions. In Study 2, Chinese and American participants judged each other on the basis of photographs, and consensus was found among Americans' judgments of Chinese and Chinese participants' judgments of Americans. Further, by correlating target effects based on within-culture zero-acquaintance judgments and cross-cultural photographic judgments, the authors found agreement in the judgments of individuals by members of their own culture and the other culture for both Chinese and Americans.

China↗

Effects of communication, information overlap, and behavioral consistency on consensus in social perception.

Three experiments (N = 69, 162, and 201, respectively) were conducted to test the mathematically derived predictions of the Weighted Average Model (D. A. Kenny, 1991) of consensus in interpersonal perception. Study 1 estimated the effect of perceiver communication. Study 2 estimated the effects of communication and stimulus overlap, and Study 3 estimated the effects of communication, overlap, and target consistency on consensus. The strongest consensus was found when perceivers communicated about highly overlapping information about targets who were cross-situationally consistent. Conversely, the lowest level of consensus was observed when perceivers did not communicate and had nonoverlapping information about targets who were cross-situationally inconsistent. Both stimulus variables (overlap and consistency) and an interpersonal variable (communication) affected consensus as predicted by the Weighted Average Model.

Adolescent↗

Interpersonal perception of the AIDS risk potential of persons of the opposite sex.

Individuals engage in high rates of AIDS risk behavior, despite awareness that infection is preventable, and use biased decision rules for determining the AIDS risk potential of their own and others' behavior. In this laboratory study, 32 male and 32 female university students made judgments of the AIDS risk potential of persons of the opposite sex following exposure to explicit information regarding AIDS-related attitudes and behavior in a discussion group. A social relations analysis showed that judgments of AIDS risk potential were determined by perceiver-based assimilation that was stronger than target-based consensus for both men and women. Further, perceptions of others were related to self-perception. However, the consensus that was observed showed moderate accuracy. Implications for AIDS prevention are discussed.

Acquired Immunodeficiency Syndrome↗

Results of a prospective randomized trial comparing standard dose neuraxis irradiation (3,600 cGy/20) with reduced neuraxis irradiation (2,340 cGy/13) in patients with low-stage medulloblastoma. A Combined Children's Cancer Group-Pediatric Oncology Group Study.

PURPOSE: To determine in a prospective randomized trial the effect on survival, progression-free survival, and patterns of relapse of a decrease in the neuraxis radiation dose from 3,600 cGy in 20 fractions to 2,340 cGy in 13 fractions in patients with newly diagnosed medulloblastoma between 3 and 21 years of age with low T stage (T1, T2 and T3A), minimal postoperative residual tumor, and no evidence of dissemination (M0). METHODS AND MATERIALS: Between June 1986 and November 1990, the Children's Cancer Group and the Pediatric Oncology Group randomized 126 patients in a two-arm study comparing the two different doses of neuraxis irradiation. In both arms, the posterior fossa received 5,400 cGy in 30 fractions. All patients were staged with myelography, postoperative lumbar cerebrospinal fluid cytology, and postoperative contrast-enhanced cranial computerized tomography to ensure no evidence of dissemination and no more than 1.5 cm3 residual tumor volume. Overall survival, progression-free survival, and patterns of recurrence were carefully monitored. Prospective endocrine and psychometric studies were performed to determine the benefit of decreasing the neuraxis radiation dose. RESULTS: Following an interim analysis at a median time on study of 16 months, the study was closed, since a statistically significant increase was observed in the number of all relapses as well as isolated neuraxis relapses in patients randomized to the lower dose of neuraxis radiation. CONCLUSIONS: In patients with newly diagnosed medulloblastoma considered to have a good prognosis on the basis of low T stage, minimal residual tumor after at least subtotal resection, and no evidence of dissemination after thorough evaluation, there is an increased risk of early relapse associated with lowering the dose of neuraxis radiation from 3,600 cGy in 20 fractions to 2,340 cGy in 13 fractions.

Adolescent↗

Consensus in interpersonal perception: acquaintance and the big five.

Consensus refers to the extent to which judges agree in their ratings of a common target. Consensus has been an important area of research in social and personality psychology. In this article, generalizability theory is used to develop a percentage of total variance measure of consensus. This measure is used to review the level of consensus across 32 studies by considering the role of acquaintance level and trait dimension. The review indicates that consensus correlations ranged from zero to about .3, with higher levels of consensus for ratings of Extraversion. The studies do not provide evidence that consensus increases with increasing acquaintance, a counterintuitive result that can be accounted for by a theoretical model (D.A. Kenny, 1991, in press). Problems in the interpretation of longitudinal research are reviewed.

Female↗

Gene therapy for cancer.

Advances in molecular biology and technology now being made will open the way to using gene transfer as a therapeutic option for patients with cancer. Since there are > 5,000 known genetic diseases, the potential impact of these techniques is enormous. Possibilities for the application of gene therapy are emerging and along with them complex safety, ethical, and financial issues that will require resolution. Many of these concerns will become relevant to the oncology nurse, who will need to understand the science, ethics, safety considerations, and impact of this experimental therapy on the patient. Since gene therapy is a rapidly evolving method of treatment, it will be a challenge to remain up to date and knowledgeable.

Female↗

Posterior fossa tumors.

Cerebellar and fourth ventricle tumors are usually associated with hydrocephalus, which is now treated with ventriculostomy and tumor removal so that permanent shunts are needed in only one third of children. Complete removals decrease the recurrence rate of cerebellar astrocytomas and ependymomas. Postoperative staging with spinal magnetic resonance imaging has decreased the need for myelography. Adjuvant chemotherapy improves the survival of children with high-stage medulloblastomas.

Cerebellar Neoplasms↗

Interpersonal perception in a social context.

Interpersonal perception among well-acquainted individuals in a social context was studied. High acquaintance was expected to provide perceivers with a large sample of target behaviors across situations. In turn, memory for acquaintances should be organized by social group and personality characteristics, as predicted by the social context-personality index theory. Differentiation of the target's traits in memory should produce a target effect on perception that is stronger than the perceiver effect. Furthermore, evidence for accuracy, meta-accuracy, independence of self- and other-perception, and reciprocity of affect were anticipated. A social relations analysis of data from a multiple-interaction, reciprocal design was used to study these phenomena. At the individual level, analyses indicated that perceptions of targets were determined primarily by target characteristics and secondarily by perceiver construction of the judgment. Also, perceivers judged targets as targets judged themselves, and targets knew in general how perceivers viewed them. Self- and other-perceptions were largely independent. Surprisingly, we did not observe dyadic meta-accuracy.

Adult↗

Consensus in personality judgments at zero acquaintance.

This research focused on the target effect on a perceiver's judgments of personality when the perceiver and the target are unacquainted. The perceiver was given no opportunity to interact with the target, a condition we refer to as zero acquaintance. We reasoned that in order to make personality judgments, perceivers would use the information available to them (physical appearance). Consensus in personality judgments would result, then, from shared stereotypes about particular physical appearance characteristics. Results from three separate studies with 259 subjects supported this hypothesis. On two of the five dimensions (extraversion and conscientiousness) on which subjects rated each other, a significant proportion of variance was due to the stimulus target. Consensus on judgments of extraversion appears to have been largely mediated by judgments of physical attractiveness. Across the three studies there was also evidence that the consensus in judgments on these two dimensions had some validity, in that they correlated with self-judgments on those two dimensions.

Beauty↗

Magnetic resonance imaging of spinal dysraphism.

MR imaging has become the definitive diagnostic procedure for the evaluation of suspected spinal dysrhaphic processes. Techniques for spinal MR imaging are discussed and MR findings in patients with surgically verified dysrhaphic spinal lesions are reviewed.

Child↗

Techniques of spinal cord surgery in fetal rats.

These experiments were done to develop techniques to expose and manipulate the spinal cord in fetal rats, techniques that could be used to study spinal cord regeneration and transplantation. Adequate maternal anesthesia required a mixture of acepromazine-ketamine supplemented by thiopental. Fetal rats were operated on at 16 to 22 days of gestation. Fetal mortality increased as the age of the fetus decreased. Microsurgical techniques were developed to expose, divide, and transplant the distal spinal cord.

Anesthesia↗