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L Alessio

Publications and source records attributed to L Alessio.

186 records · Page 11Linked to original sources
PubMedDate not supplied

[The health surveillance of personnel who handle antineoplastic agents].

The health surveillance of workers exposed to antineoplastic drugs is based on the fact that these substances are potentially carcinogenic to humans and can cause adverse reproductive effects, as well as irritative and allergic reactions. Health checks must be carried out before starting the job and at periodic intervals thereafter depending on the degree of exposure. These checks will have to evaluate possible physiological and pathological conditions of individual susceptibility. In addition to occupational and pathological history, and physical examination, health surveillance must include tests for the evaluation of hemopoietic, renal and liver functions. Cytogenetic studies on individual workers can be proposed only after documented abnormal exposures to antineoplastic drugs or in case of adverse effects suspected to be caused by this type of exposure.

Antineoplastic Agents↗
PubMedDate not supplied

Multiple exposure to metals in eight types of welding.

This article evaluates multiple exposures to metals in different types of metal welding such as manual metal arc for mild and stainless steel, continuous wire, submerged arc, laser and brazing. Environmental monitoring was carried out in eight different occupational situations and the inductively coupled plasma mass spectrometry technique was adopted in order to characterize exposure to several elements simultaneously and with high accuracy. The results showed that up to 23 elements could be measured. The highest concentrations were found for Al, Mn, Fr, Ni, Cr, Cu and Zn. For some elements such as In, Nd, I, Rb the concentrations were very low. A qualitative and quantitative variation in fume composition was observed at a certain distance from the welding point, which should be to taken into account when evaluating indirect exposures. It would also be possible, with this technique, to identify specific elements in the mixture which could also be measured in biological fluids.

Air Pollutants, Occupational↗
PubMedDate not supplied

[The toxicology and prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. I. Guide lines for the prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. Società Italiana Valori di Riferimento and Cattedra di Medicina del Lavoro, Università di Brescia].

These guidelines mainly deal with prevention of carcinogenic effects following occupational exposure to polycyclic aromatic hydrocarbons (PAH). After some toxicological remarks, the guidelines define a possible method to demonstrate and evaluate occupational exposure to PAH. In particular, it is illustrated the strategy of environmental monitoring and indicated which PAH should be measured, with suggestion about the most appropriate analytical techniques. As regards biological monitoring, the 1-OH-pyreneseems to be currently the most useful indicator since it reflects the recent and global exposure to PAH. The guidelines also give elements to interpret monitoring data, taking into account environmental and biological reference and limit values suggested by some authors, Associations, or current regulations. The most important health effects are carcinogenic and excess risks have been described mainly for lung, bladder and skin cancer in some PAH exposed workers. The studies on cytogenetic effects showed contradictory results. On the basis of such information and current regulations, the guidelines show how to perform health surveillance in preventive and periodical examinations and how to proceed for the information and formation of exposed workers. It is not advisable, on the basis of the current scientific data, to screen asymptomatic PAH exposed workers for early diagnosis of lung or bladder cancer, nor it is opportune the use of tumor markers for health surveillance nor is genetic screening applicable for individual susceptibility evaluation outside research programs.

Carcinogens↗
PubMedDate not supplied

[Occupational medicine: a discipline in constant evolution among debates, didactic, research, and clinics. Is the white coat still useful?].

Occupational medicine: a discipline in constant evolution among debates, didactics, research and clinics. Is the white coat still usefull? Occupational Medicine is a discipline in constant evolution: due to the changes in the technological processes and the prevention measures adopted, the classical Occupational diseases changed their pictures and new diagnostic problems emerge for the Occupational Physician. This specialist, even if he is more and more involved in preventive activities, cannot neglect a deep clinical preparation. In fact, when the Occupational Physician is involved in the field of health surveillance, he must express fitness evaluations that need careful diagnostic procedures. The debates and inside our discipline and between Occupational Health Physicians and other specialists have allowed to reach high level results in many fields of Occupational Medicine, educational, research, clinics, prevention.

Humans↗