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Biomedical subjects

L Andreassi

Publications and source records attributed to L Andreassi.

94 records · Page 6Linked to original sources

Inhibition of cAMP phosphodiesterase by some phototherapeutic agents.

The behaviour of cyclic-3',5'-AMP phosphodiesterase has been studied in the presence of psoralen, 8-methoxy-psoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) (usually used in PUVA therapy), 4,6,4'-trimethylangelicin (TMA) and khellin recently proposed for the same therapeutical use. TMP and TMA exhibit a significant inhibitory effect on cyclic AMP phosphodiesterase; a light inhibition is produced by khellin at rather high concentration.

3',5'-Cyclic-AMP Phosphodiesterases↗

[Draize's test in assessment of eye tolerance to various cosmetic products].

The methods of Marzulli-Ruggles and Draize were used in an assessment of eye irritation on the part of three children's shampoos. Two products proved irritant with the Marzulli-Ruggles method. The most aggressive product was designated VAS-2-36/A. Better tolerance was observed in albino rabbits when the Draize method was used, though even here some ocular alterations were noted. Once again, VAS-2-36/A was the most irritant substance.

Animals↗