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Biomedical subjects

L Appelgren

Publications and source records attributed to L Appelgren.

At least 55 records · Page 3Linked to original sources
PubMed1976

Vascular and extravascular spaces in a transplantable rat tumour after local X-ray irradiation.

Local X-ray irradiation of a transplantable rat tumour in a single dose of 3000 R increased significantly the extracellular space of this tumor as estimated by the plasma-tissue equilibration of 51Cr-EDTA, while the plasma and red blood cell volume as estimated with 125I-labeled albumin and 59Fe-labelled erythrocytes after sacrifice by bleeding under ether anaesthesia were unchanged. These results combined signified a decreased cell volume of cells, excluding red blood cells.

Animals↗
PubMed1975

Plasma volume after dextran infusion in rats sensitive and non-sensitive to dextran.

Plasma volume determinations were done with RIHSA under normal conditions and after intravenous infusion of dextran solutions. The plasma volume of normal rats in millilitre was found to be 0.026 X body weight + 0.92. Infusion of dextran into dextran-sensitive Sprague-Dawley rats was followed by a marked plasma volume reduction and haemoconcentration as consequence of an anaphylactoid reaction. This reaction could be partially inhibited by pretreatment with cyproheptadine chloride. Plasma volume determination with the method used in this study can be used to evaluate the dextran-anaphylactoid reaction. In dextran non-sensitive Wistar rats, infusion of dextran had a strong plasma volume-expanding effect comparable to the plasma volume-expanding effect of dextran in humans. No signs of abnormal leakage of fluid out into the extravascular space were evident, which indicated that the Wistar rats really were non-sensitive to dextran.

Animals↗