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Biomedical subjects

L Auerbach

Publications and source records attributed to L Auerbach.

7 recordsLinked to original sources
PubMed1995

A prospective analysis of immunohistochemically determined hormone receptors and nuclear features as predictors of early recurrence in primary breast cancer.

The immunohistochemically determined receptor status, as well as first-generation risk factors (tumor size, lymph node status, histologic grading including subfactors, tumor histology, and biochemically determined receptor status) were prospectively analyzed in 288 cases of primary breast cancer for their impact on recurrence-free survival (RFS) and overall survival (OS) after a median observation period of 41 months. Immunohistochemically (ER-ICA) and biochemically determined estrogen receptors (ER-DCC), as well as tumor size, lymph node status, histologic grading, mitotic rate, and nuclear polymorphism, were of prognostic value for recurrence-free survival and/or overall survival. In multivariate analysis, lymph node status, tumor size, and mitotic rate proved to be independent prognosticators; ER-ICA showed significance in the univariate analysis which dropped, however, when multivariate analysis was applied. The prognostic power of histologic grading in our series seemed to depend mainly on the subfactors which relate to nuclear features.

Adult↗
PubMed1995

Maternal alloimmunization against fetal platelet antigens: a prospective study.

Neonatal alloimmune thrombocytopenia (NAIT) is induced by maternal alloantibodies to fetal platelet antigens. This prospective study was carried out to evaluate the incidence of anti-platelet antibodies in 933 mother-child pairs where the mother and child were typed for the human platelet antigens (HPA)-1, -2, -3, -5. Sera from mismatched mother-child pairs were screened for anti-platelet antibodies, anti-HLA class I and blood group ABO IgG antibodies. Platelet-specific antibodies were anti-HPA-3a in one and anti-HPA-5b in 17 neonates, respectively. All these neonates had normal platelet counts. One woman had autoreactive antibodies. Anti-HLA class I and anti-blood group A IgG antibodies were detected in five and four neonates, respectively, born with a platelet count < 150 x 10(9)/l. None of the 11 homozygous HPA-1b mothers became immunized against their heterozygous offspring. The maternal HLA-allotypes HLA-DR52 and -DR6, typically found in individuals immunized against HPA-1a and -5b, respectively, were found in three of 11 HPA-b/b nonresponders and eight of the anti-HPA-5b responders. The results indicate that a risk for NAIT due to HPA-2 and -3 alloimmunization is low. The HLA allotypes do not predict the risk for NAIT due to HPA-1 or -5 alloimmunization. Maternal anti-HPA-5b antibodies do not correlate with the platelet count in the neonate.

ABO Blood-Group System↗
PubMed1994

Preoperative and postoperative CA-125 serum levels in primary fallopian tube carcinoma.

Levels of CA-125 were determined pre- and postoperatively in 13 patients with fallopian tube cancer. Values before surgery were significantly higher (Median 1220 IU/ml, 90-5000 IU/ml) compared with postoperative levels (Median 194 IU/ml, 67-880 IU/ml) (P = 0.0052). Correlation analysis with FIGO stage and grading failed to show any statistical significance, but a trend for a positive correlation with FIGO stage and preoperative values could be observed. The CA-125 antigen is expressed by fallopian tube carcinoma and should therefore be used in diagnosis and follow-up.

Adenocarcinoma, Mucinous↗
PubMed1994

A comparative analysis of management and prognosis in stage I and II fallopian tube carcinoma and epithelial ovarian cancer.

Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 with OC, in stage I and II were included into this study. A univariate as well as a multivariate analysis for survival was performed, including factors such as age, histological type, grading and surgical and adjuvant treatment. A significantly poorer outcome (P = 0.0002) for FTC patients with a 5-year survival of 50.8% compared with 77.5% for OC patients was observed. This finding was persistent and independent of any investigated factor, in univariate as well as multivariate analyses. Therefore, we feel that a more aggressive therapeutic approach to the treatment of FTC even in early stages can be recommended. On the other hand, the retrospective character of our study has to be taken into account.

Age Factors↗
PubMed1978

Microcrystalline identification test of some amphetamines and hydrochlorothiazide: collaborative study.

A previously described procedure for the identification of methamphetamine, dl-deoxyephedrine, dextroamphetamine, and amphetamine and a new procedure for hydrochlorothiazide identification have been subjected to collaborative study. The method for the amphetamines depends upon their volatilization from a strongly basic solution into a hanging drop containing gold chloride and the formation of characteristic crystals. The hydrochlorothiazide method is direct: the I2-KI solution is added to an alkaline solution of hydrochlorothiazide to cause the deposition of characteristic crystals. Of the 40 unknown drug dosage form powders supplied to 10 collaborators, 39 were correctly identified. The results indicate that the amphetamine procedure is capable of distinguishing between methampetamine and dl-deoxyephedrine. The age of the gold chloride reagent is important in these tests. The official final action tests for dl-deoxyephedrine and methampetamine were modified and Table 36:04 has been revised to reflect these changes. The hydrochlorothiazide test has been adopted as official first action and added to Table 36:05.

Amphetamines↗
PubMed1977

Use of three optical systems to obtain a microscopic profile of asbestos and other nonopaque particulate matter larger than 5 mum in parenteral drugs.

A comparative microscopic study of chrysotile fibers was conducted, using 3 sequential optical systems: plane polarized light (PL), phase contrast (PC), and Nomarski differential interference contrast (NDIC) for complementary image analyses. The introduction of NDIC for qualitative and quantitative analyses of particulate matter greater than 5 mum resolves the problem of diffraction halos encountered in PC microscopy. High optical contrast, the instrumental characteristic of NDIC, is particularly useful for the detection of chrysotile fibers at a magnification of 500 X.

Asbestos↗