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Biomedical subjects

L B Engesaeter

Publications and source records attributed to L B Engesaeter.

51 records · Page 3Linked to original sources
PubMed1984

Stability of femoral neck osteotomies fixed by von Bahr screws or by compression hip screw.

Subcapital cadaveric femoral neck osteotomies were internally fixed either by a compression hip screw and a lag screw or by two von Bahr screws. The specimens were then subjected to mechanical testing. Continuously increasing axial compression loads were applied on the femoral head until failure and simultaneously the displacement of the osteotomies was measured. With loads up to 2 kN (about 3 times the body weight) no differences were found between the two groups in the displacement of the osteotomies.

Aged↗
PubMed1984

Knee function following suture of fresh tear of the anterior cruciate ligament.

A retrospective consecutive series of 60 patients treated with primary suture of knee ligament injuries is presented. All patients had an anterior ligament (ACL) tear. In 54 patients this injury was combined with a medial compartment tear. Four patients had isolated tears of the ACL. At follow-up after 4 years, 11 patients complained of instability, and in eight of these an anterolateral rotatory instability was demonstrated by the Slocum test. In contrast, only five of 49 patients with subjectively stable knees had positive Slocum tests. Thirty of 47 patients with negative Slocum tests had excellent function, compared with four of 13 patients with positive tests.

Adolescent↗
PubMed1984

Extra-articular stabilization of the knee a.m. Losee.

During 1979-81, 34 patients were operated according to Losee for chronic disabling anterior cruciate insufficiency. Twenty-nine patients were available for follow-up after 2 (1-4) years. At follow-up, 20 patients had a negative Slocum test. Twenty-one patients had a Lysholm knee score greater than 77 points, and were classified as good or excellent, with a significant relation to anterolateral stability.

Adolescent↗
PubMed1984

Primary repair in posterior cruciate ligament injuries.

A retrospective study of 32 consecutive patients with acute injury of the posterior cruciate ligament (PCL) treated by primary repair is presented. Only six patients had isolated injuries of the PCL, five of these as avulsion of a bone fragment from the tibia. The remaining 26 patients sustained combined ligament injuries, including 18 total ACL tears. All ruptured ligaments were repaired. At follow-up after 4 (1-7) years, function in 26 patients was excellent-good and in six fair-poor. Moderate or severe posterior instability was found in seven patients by clinical examination but their function was as good as in those with stable knees. Inferior functional results, however, were more often related to rotatory instability. Primary repair of PCL-injuries, including all associated ligament injuries, is recommended.

Adolescent↗
PubMed1983

Mechanical properties of bone and skin during recovery after cyclophosphamide administration.

The effects of cyclophosphamide were studied 2, 5 and 9 days after terminating a two-week every-second-day intraperitoneal medication in young, male rats. The cytostatic effect was assessed by counting white blood cells (WBC) in arterial blood. WBC counts were reduced by 72% of control values at 2 days and regained normal values at 9 days after an overshooting leucocytosis at 5 days. Compared to control animals, the treated rats had significantly reduced body weights, metaphyseal bending strength and longitudinal growth of the femur at all time intervals observed. The torsional strength of the femur diaphysis and the strength of wounded skin were not affected at 2 days, but significantly reduced at 5 and 9 days. The tensile strength of intact skin was not found to be affected by the drug. From the 5th to the 9th day after ending medication, the curves for control and treated animals were assuming parallel slopes regarding metaphyseal bone strength, longitudinal bone growth and tensile strength of wounds. This may indicate reversion of the drug effects approximately one week after terminating medication.

Animals↗
PubMed1981

Mechanical properties of fractured and intact rat femora evaluated by bending, torsional and tensile tests.

Mechanical properties of healing fractures and growing, intact bones were studied in male rats aged 8 weeks at the beginning of the study period. A standardized, closed fracture was produced in the middle of the left femur. The fracture was not immobilized. At various intervals after the fracture, the healing fractured femora and the contralateral, intact femora were subjected to bending, torsional and tensile tests. The fractured femora regained the strength and the ultimate deformation of the contralateral, intact femora after about 8 weeks when tested in bending, and after about 13 weeks when tested in torsion. In the first phases of fracture repair, the healing fractures could resist more torsional moments increased with increase in age and weight of the animals, whereas the ultimate angular deformation remained constant. The ultimate bending and torsional stresses (bone material strength) increased to reach a plateau when the rats were about 14 weeks old. No significant differences were observed between the bending, torsional and tensile application.

Animals↗
PubMed1980

Effects of oxytetracycline on solubility and synthesis of collagen in young rats.

In a recent study we demonstrated that the antibiotic oxytetracycline reduces both growth and mechanical strength of bone and skin in young rats. The present study deals with the effects of 14 days of oxytetracycline medication on salt solubility of collagen (cross-linking) and conversion of 14C-proline to 14C-hydroxyproline in collagen (synthesis). At the end of the medication period, significantly higher solubility of collagen was found in the femurs and skin of rats receiving oxytetracycline than in controls. No effect of the antibiotic on the rate of collagen synthesis could be demonstrated. These findings may indicate that oxytetracycline in young rats causes reduced mechanical strength of bone and skin by interfering with the cross-linking of collagen.

Animals↗
PubMed1980

Effects of oxytetracycline on mineralization of bone in young rats.

The metabolism of minerals and collagen in young rats receiving oxytetracycline was studied by employing double-isotope techniques. The dosage of the antibiotic was adjusted to obtain plasma concentrations comparable with human therapeutic levels. Reduced mineralization and possibly increased resorption of bone were observed after oxytetracycline administration, whereas no effect on the rate of collagen synthesis could be detected.

Age Factors↗
PubMed1980

Effects of cloxacillin, doxycycline, fusidic acid and lincomycin on mineralization and solubility of collagen in young rats.

The antibiotics doxycycline, fusidic acid and lincoymcin have recently been shown to reduce growth of bones and tensile strength of skin in young rats. Such adverse effects were not found in rats receiving cloxacillin. The present investigation deals with the influences of these four antibiotics on the mineralization of bones and on the solubility of collagen in skin. In rats receiving doxycycline the content of calcium and phosphorus in bones and the concentration of albumin in serum were reduced. None of the antibiotics had a detectable effect on the solubility of collagen.

Animals↗
PubMed1979

Effects of cloxacillin, doxycycline, fusidic acid and lincomycin on the mechanical properties of bone and skin in young rats.

The influence of cloxacillin, doxycycline, fuside acid and lincomycin on the mechanical properties of bone and skin in young rats was examined. The concentrations of the antibiotics in plasma corresponded to therapeutic levels in man. After 14 days of medication the weights of the rats receiving cloxacillin or doxycycline were significantly less when compared with the controls. The doxycycline, the fusidic acid and the lincomycin treated rats had reduced longitudinal growth of femur and reduced tensile strength of intact skin. No differences between any of the antibiotic groups and the control group were found in the tensile strength of incisional skin wounds or in the mechanical properties of the femur and tibia.

Animals↗
PubMed1979

Effects of cyclophosphamide on mechanical properties of bone and skin in rats.

The effects of several different doses of cyclophosphamide on weight increase, longitudinal bone growth and mechanical properties of bone, intact skin and skin wounds, were studied in 30 young, male rats. The cystostatic effect was evaluated by counting white blood cells (WBC) in arterial blood at the end of the medication period. Compared with the control animals, the longitudinal bond growth, the mechanical properties of the distal femoral metaphysis and the skin wounds were most noticeably affected by the drug. Diaphyseal torsional strength of the femoral bone and tensile strength of intact skin were less affected.

Animals↗
PubMed1978

Methods for testing the mechanical properties of the rat femur.

A modular apparatus to measure the bending and torsional properties of the rat femur is presented. Both intact femur diaphyses and diaphyseal fractures in different phases of healing can be tested. It is also possible to measure the bending-strength of the distal femur metaphysis and the epiphyseal plate. The apparatus can be used to investigate the effect of drugs and hormones on the remodelling of the rat femur.

Animals↗
PubMed1978

Effects of oxytetracycline on the mechanical properties of bone and skin in young rats.

The influence of the tetracycline antibiotics on growing bones has been disputed. In the present study 58 young male rats were given intraperitoneal injections twice a day for 2 weeks; half of the rats received oxytetracycline and the other half placebo. The concentration of oxytetracycline in plasma was comparable with therapeutic levels in man. Compared with the control animals the oxytetracycline rats had, at the end of the medication period, a significantly lower weight (7 per cent), shorter bones (1--2 per cent), lower bending strength of both the tibia diaphysis (9 per cent) and the distal femur metaphysis (22 per cent) and even lower tensile strength of intact (17 per cent ) and sutured (27 per cent) skin. The effect oxytetracycline seems to be reversible as no differences between the two groups could be detected 1--3 weeks after the end of medication.

Animals↗
PubMed1977

Unilateral and bilateral partial laminectomy in lumbar disc prolapse. A follow-up study of 156 patients.

The results of two comparable groups of in all 156 operated patients with lumbar disc prolapse were evaluated 4-9 years postoperatively. Sixty-seven patients had received bilateral and 89 unilateral partial laminectomy. At follow-up, the results of the bilaterally operated were all excellent or good, whereas 15% with unilateral exposure were unchanged or worse. The unilaterally operated presented a significantly higher incidence of low back pain and recurrences of sciatica than the bilaterally operated. There were no reoperations for recurrent prolapses following the bilateral approach compared with four after unilateral approach. It is concluded that bilateral partial laminectomy affords a good view of the disc pathology and a greater possibility for obtaining relief of the symptoms without reducing the stability of the column.

Adult↗