Antitumor antibiotics and interleukin-2: a prediction.
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Biomedical subjects
Publications and source records attributed to L B Greentree.
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Antibiotics are chemical substances produced by living microorganisms which have the capacity to inhibit or kill other microbes of a different class. They were used successfully to revolutionize the treatment of infectious disease several decades ago. It is hypothesized that the concept of antibiosis or microbe antagonism will do the same for the treatment of cancer during the forseeable future. It is predicted that anti-cancer antibiotics, still mostly unidentified in the environment, which can be classified as being Biologic Response Modifiers to enhance the host's natural immune defenses against cancer, will prove to be the chief weapon to win the final battle against invasive cancer. However, to reach that goal the basic laws of immunity, including that of anamnesis, will have to be implemented and not ignored.
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Malariotherapy merits a clinical trial as an adjuvant to conventional cancer therapy. This particular modality of treatment is a most potent stimulus of macrophage activity. These scavenger cells are widely believed to be an essential arm in the host's immune defenses against malignant disease, both as regards the processing of antigens and as killers of tumor cells. Significant too, malariotherapy, as formerly used to effectively treat some 16,000 patients with paretic neurosyphilis in one institution alone, before the advent of the penicillin age, has proved to be a particularly safe modality of treatment.
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