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Biomedical subjects

L B Harden

Publications and source records attributed to L B Harden.

11 recordsLinked to original sources
PubMed1982

Probable toxic shock syndrome without shock and multisystem involvement.

Three menstruating adolescents using tampons colonized with Staphylococcus aureus developed high fever, vomiting, diarrhea, and abdominal pain followed by conjunctival injection and a sunburn-like rash. Two girls had transient orthostatic hypotension but none developed shock or evidence of multiple organ injury. They are reported as having probably toxic shock syndrome without shock or multiple organ system involvement.

Adolescent↗
PubMed1980

Simultaneous hemodialysis and exchange transfusion in hemolytic uremic syndrome.

We report our experience in the acute management of a seven-year-old child with severe hemolytic uremic syndrome. On three separate occasions, acute neurologic signs dramatically resolved during simultaneous exchange transfusion and hemodialysis. The ease with which exchange transfusion may be combined with acute hemodialysis is discussed. In selected cases of hemolytic uremic syndrome with marked neurologic manifestations, exchange transfusion may offer a benefit similar to that reported in adults with thrombotic thrombocytopenic purpura.

Child↗
PubMed1976

Rapid infusion of sodium bicarbonate and albumin into high-risk premature infants soon after birth: a controlled, prospective trial.

We conducted a controlled, prospective trial to evaluate the effectiveness of rapidly infusing sodium bicarbonate (NaHCO3) and salt-poor albumin into high-risk, premature infants in the first 2 hours of life. Fifty-three infants, randomized into one of four treatment groups, received 8 ml. per kilogram of a solution containing either (A) glucose in water, (B) salt-poor albumin, (C) NaHCO3, or (D) a combination of albumin and NaHCO3. After the initial infusion, the babies received no colloid or alkali solutions until 4 hours of age. We managed them supportively with warmth, appropriate oxygen administration, isotonic fluid infusion, and close monitoring. Among the infants who received alkali, 14 of 26 acquired the respiratory distress syndrome (RDS), 11 died, and four had intracranial hemorrhage. Among babies who received no alkali, RDS occurred in 11 of 27, 5 died, and none had intracranial hemorrhage. These results do not support the common practice of rapidly infusing NaHCO3 into high-risk, premature infants, and they suggest that the early management of such infants needs renewed critical evaluation.

Acidosis↗