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Biomedical subjects

L B Ostrow

Publications and source records attributed to L B Ostrow.

12 recordsLinked to original sources

Needle-localized biopsy of occult breast lesions: an update.

We have performed 207 needle-localized breast biopsies for nonpalpable, mammographically suspicious lesions over the past 6 years. A mass lesion and grouped microcalcifications were associated with malignancy, while a mass with microcalcifications was never associated with malignancy. Biopsy revealed malignancy in 26 cases (12.6%), with 19 of 22 (86.4%) having no histologic evidence of axillary spread. Advanced age and a past history of a breast cancer were again the risk factors present in a significant number of the patients with a positive biopsy result. There were 11 complications (5.3%): three hematomas (1.4%), one infection (0.5%), and seven (3.4%) required a repeat biopsy to remove the suspicious lesion missed on the original biopsy. We conclude that needle-localized breast biopsy continues to be a reliable method of detecting early breast carcinoma. Given the minimal morbidity, this procedure should be done in all patients with mammographically suspicious nonpalpable breast lesions.

Adult↗

The solitary pulmonary nodule: a recent military experience.

During a 5-year period from 1983 to 1987, a total of 226 thoracotomies were performed at David Grant USAF Medical Center. Within this group, 62 patients (27%) had resection of a solitary pulmonary nodule. Fifty percent of the resected nodules were subsequently proven malignant, with 27 of 62 (43%) having a primary lung carcinoma. From 1958 to 1963, the Veterans Administration Armed Forces Cooperative Study evaluated a total of 1,134 patients with asymptomatic solitary pulmonary nodules. The data generated from that report has become the standard within the literature. We compared our recent 5-year experience to that data. The primary difference found in our series was an increase in solitary pulmonary nodules in our female population.

Adult↗

Wound complications following modified radical mastectomy: an analysis of perioperative factors.

To assess the effect of perioperative factors on the incidence of postoperative wound complications, the authors retrospectively analyzed 101 patients who had undergone modified radical mastectomy. These factors included age, body weight, operative techniques, estimated blood loss, wound-catheter drainage, extent of axillary dissection, nodal involvement, and length of hospital stay. Complications included seroma (10.9%), wound infection (8.9%), wound necrosis (5%), hematoma (3%), lymphedema (2%), and pneumothorax (1%). The logistic regression method was used to analyze the data. When electrocautery was used to create the skin flaps, the probability of a wound complication was .462, a 44% increase over that calculated for the cold-knife technique (P = .05). A prolonged hospitalization accompanied the occurrence of a wound complication. No other factors reached statistical significance.

Adult↗

Atypical carcinoid tumor of the lung: a case report and discussion of the literature.

Carcinoid tumors comprise 1% to 2% of all tumors of the lung. Although carcinoid tumors are generally felt to be of low grade malignancy, an atypical variant exists that exhibits more virulent behavior and a less favorable prognosis. The treatment of carcinoid tumors is complete surgical removal and a more aggressive approach is required in the treatment of atypical carcinoids. A case is presented with a review of the literature.

Adult↗

Transcatheter embolization of small bowel anastomosis: a case report and review of the literature.

A 45-year-old woman underwent exploratory laparotomy for recurrent intra-abdominal abscesses subsequent to a sigmoid resection for diverticulitis. Her postoperative course was complicated by massive hemorrhage from a small bowel anastomosis, which was successfully managed with transcatheter embolization. To our knowledge, this report documents only the second recorded successful embolization of a bleeding small bowel anastomosis. In certain high-risk patients, transcatheter embolization may be considered a useful adjunct in the management of gastrointestinal hemorrhage including anastomotic bleeding.

Anastomosis, Surgical↗

Needle-localized biopsy of occult breast lesions.

Over a 3 1/2-year period, we did 121 needle-localized breast biopsies for nonpalpable, mammographically suggestive lesions. The presence of a mass lesion on mammography with or without microcalcifications was associated with malignancy more frequently than microcalcifications alone. In 15 cases (12.4%), biopsy showed malignancy; 13 patients had modified radical mastectomy, with 11 (85%) having no histologic evidence of axillary metastases. Evaluation of risk factors associated with breast cancer in those patients with positive biopsy results showed that advanced age and a past history of a breast cancer were present in a significant number of patients. Four patients (3.5%) had complications; a hematoma developed in one (0.8%), and three (2.7%) required a second biopsy to remove the suggestive mammographic lesion. We conclude that needle-localized breast biopsy is a reliable tool in detecting early breast carcinoma. The procedure causes only minimal morbidity and we believe it should be done in all patients with mammographically suggestive, nonpalpable breast lesions.

Adult↗

Burns in the elderly.

The records of 327 burn patients over age 65 show that flame burns were the most common causative agent and that more than 70 percent of all burns occurred in the home. Despite improved treatment, mortality from burns remains unacceptably high among the elderly. Future efforts must be directed toward the prevention of these injuries, especially those sustained in the home.

Accidents, Home↗

Staging of non-small cell bronchogenic carcinoma. Relationship of the clinical evaluation to organ scans.

Organ scans are generally performed on patients with bronchogenic carcinoma only when clinical evaluation is suspicious for metastases. However, it is not clear whether the clinical abnormalities will direct attention to the single organ which should be scanned, or if all three organs (bone, brain, liver) should be evaluated if any clinical abnormality is present. We investigated the use of triple organ radionuclide scanning and computerized tomography (CT) of the brain in the initial staging of patients with non-small cell bronchogenic carcinoma with no obvious metastases. Of 122 patients with newly diagnosed lung cancer, 53 met our criteria for further study. Thirty-three (62 percent) of these had at least one clinical abnormality suggestive of metastasis. Bone scanning detected metastases in seven (21 percent) and head CT in two additional patients (6 percent). Brain and liver scanning had no yield. In only five of these nine patients did the clinical abnormality direct attention to the organ with detectable metastases. Twenty of the 53 (38 percent) patients had a negative routine clinical evaluation, yet bone scanning showed metastases in three (15 percent). We concluded that clinical abnormalities are not specific for the organ in which metastases may be detected, so three scans (bone, liver, CT of the brain) should be obtained if there is any suspicion of metastasis based on history, physical examination, and laboratory tests. The value of bone scanning in clinically normal patients deserves further study.

Adult↗

Report from the California Burn Registry--the causes of major burns.

In its first four years of operation, the California Burn Registry recorded 3,332 cases of burns, of which 73.1% were in male and 26.9% were in female patients of all ages. The average total body surface area burned was 15.4+/-0.3%. Flame burns were the most common (31.4%). Other common sources included scalds (24.5%) and flammable liquids (12.9%). Several other causes were cited with less frequency. Burns taking place at home occurred more commonly than at all other locations combined. In all, 221 deaths (6.6%) were reported, most (66.1%) of which were due to flame burns.

Adolescent↗