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L B Snopova

Publications and source records attributed to L B Snopova.

12 recordsLinked to original sources
PubMed2004

[Optic coherent tomography in evaluation of the buccal mucosa status. Communication 1. Normal mucosa].

The potentialities of optic coherent tomography (OCT) in the diagnosis of the buccal mucosa status were studied and the results are presented in two communications. Communication 1 demonstrates the tomograms of various parts of normal buccal mucosa and methods of their identification as exemplified by analysis of 1180 in vivo and 43 ex vivo OCT images. Using parallel histo-tomographic comparison, the authors distinguished the main signs of optic images, depending on the type of epithelium and characteristic features of the connective tissue stroma in various parts of the buccal mucosa. These signs are essential for understanding the optic images of the mucosa in disease, which will be shown in communication 2.

Adult↗
PubMed2004

[Optical coherence tomography in the evaluation of the oral cavity mucosa. Part II. Benign and malignant diseases].

This paper is the last one in the series of publications on the investigation of the capability of Optical Coherence Tomography (OCT) in diagnostic of state of oral cavity mucosa. Part II demonstrates the diversity of optical images, different forms specific to leukoplakia, lichen planus and squamous cell carcinoma on the basis of the investigation of 56 pathologic lesions of 43 patients with precancer and cancer of oral cavity. The OCT sensitivity in malignancy detection in oral cavity is high - 83%, specificity is 98%, and accuracy is 81%. The kappa coefficient of interobserver agreement is 0.76.

Carcinoma, Squamous Cell↗
PubMed2001

Optical coherence tomography monitoring for laser surgery of laryngeal carcinoma.

BACKGROUND AND OBJECTIVES: The goal of this study is to apply a new bioimaging modality, the Optical Coherence Tomography (OCT), for intraoperative control in laser surgery of laryngeal carcinoma. STUDY DESIGN/MATERIALS AND METHODS: We studied 26 patients with laryngeal carcinoma in situ and in T(1), T(2) stage. We used an endoscopic OCT device for imaging at a wavelength of 0.83 microm with the acquisition rate of approximately 0.5 frames/s for a single (200 x 200 pixel) tomogram. All patients were operated with a surgical YAG:Nd laser at two switchable wavelengths of 1.44 microm and 1.32 microm by laryngofissure, direct microlaryngoscopy, and fibrolaryngoscopy. RESULTS: Information on structural alterations in laryngeal mucosa to the depth of 2 mm, obtained by OCT, makes it possible to precisely locate tumor borders, thus giving an opportunity to control the surgical treatment of laryngeal carcinoma. The YAG:Nd laser scalpel with wavelengths of 1.32 microm and 1.44 microm is successful in surgical procedures both in open and closed larynx due to efficient coagulation and minimization of collateral tissue damage area. Combination of the two wavelengths in the single laser unit and intraoperative OCT monitoring result is a new modality for minimally invasive larynx surgery. CONCLUSIONS: OCT is promising to become a new diagnosing method of laryngeal carcinoma and a tool for laser treatment monitoring.

Carcinoma in Situ↗
PubMed1993

[Effect of various levels of hypothermic ischemia on ATPase activity of the functional element of the myocardium].

Activity of ATPase in functional element of myocardium (its qualitative and quantitative aspects) has been researched in normal tissue and in one with various levels of hypothermic ischemia (28-30 degrees C and 10-12 degrees C) by methods of electron microscopic histochemistry on dogs. It has been found that hypothermia of myocardium (10-12 degrees C) optimally prevents ischemic disorders of energetic processes. Reproduction activity of ATPase during reperfusion of myocardium after that hypothermia maintains contractile function of heart in proper high level.

Adenosine Triphosphatases↗
PubMed1987

[Erythrocyte and microcirculatory functions during artificial circulation].

Erythrocyte morphology, their aggregation ability and microcirculatory pattern in the mesentery of the small intestine have been studied stepwise on 12 dogs under artificial blood circulation. It has been shown that erythrocyte lesions followed by pathological aggregation play an important role in the pathogenesis of microcirculatory failure. Prolonged artificial circulation provokes structural reorganization in erythrocytes, thus affecting both blood rheology and gas exchange.

Animals↗
PubMed1985

[Optimal timing of radical surgery for tumors of the pancreaticoduodenal zone associated with jaundice].

In cancer of the pancreatoduodenal zone complicated by obturative jaundice it is expedient to perform pancreatogastroduodenal resection in two steps: the first step is laparoscopic hepatocholecystostomy, the second step should be fulfilled 10-12 days after normalization of bilirubinemia. The data obtained were taken into consideration in pancreatogastroduodenal resection performed in 20 patients.

Ampulla of Vater↗
PubMed1984

[Effect of sodium oxybutyrate on macroergic phosphates, function and ultrastructure of the myocardium in blood loss].

Experiments on dogs with long-term hypotony caused by blood loss have demonstrated irreversible lesions in the majority of cardiomyocytes and hypodynamic condition of the heart with a high content of macroergic phosphates in the myocardium. Intravenous injection of sodium hydroxybutyrate in a dose of 180-200 mg/kg after 60 min of hypotony seems to improve energy transport and utilization in the ischemic myocardium. It increases the working capacity and power of the heart muscle, pump function of the heart and makes longer the period of ultrastructural changes in cardiomyocytes.

Adenosine Diphosphate↗
PubMedDate not supplied

[Optic coherent tomography: a new high-resolution technology of visualization of tissue structures. Communication II. Optical images of benign and malignant entities].

This is the second communication of a series of publications on Russian studies in the field of optical coherent tomography (OCT), the newest noninvasive highly resolving technology of visualization of the structure of biological tissues. By using the investing tissues as an example, this paper demonstrates the universal types of changes in their optical properties. Optimal images permit differentiate benign and malignant processes with a high degree of diagnostic accuracy. Diverse benign processes occurring in the epithelium are detected on the OCT images as changes in its height, the scattering properties and stroke of a basilar membrane. The absence of any structure on the image is the main OCT criterion for malignancy. The diagnostic efficiency of OCT is high in recognizing neoplasia of various mucous membranes: the sensitivity of the technique is 77-98%; its specificity and diagnostic accuracy are 71-96 and 81-87%, respectively.

Adult↗
PubMedDate not supplied

[The adaptive-compensatory reactions of the pulmonary microcirculatory bed in experimental pneumonia].

Pulmonary microcirculation was studied in anesthetized interbred male cats with acute pneumonia in acute experiments by the method of intravital microscopy. Due to the reticular structure of the lung microcirculatory channel and the change of the direction of the blood flow in microvessels stretching to the focus of inflammation, collateral circulation developed rapidly and facilitated redistribution of the blood flow in the pulmonary lobe involved in the inflammation.

Acute Disease↗
PubMedDate not supplied

[The role of cytochrome c in preventing postresuscitation functional disorders of the central nervous system].

The effect of intracarotid injection of cytochrome c on the course of the early postresuscitation period was studied in experimental animals (albino rats) after 5-min clinical death from acute blood loss. It was shown that the drug normalizes the disturbed metabolic processes in the brain, reduces the structural changes consequent upon total ischemia, stabilizes the activity of the cardiovascular system and, as a result of this, contributes to restoration of functional activity of the central nervous system in the early postresuscitation period.

Acute Disease↗