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Biomedical subjects

L B Stone

Publications and source records attributed to L B Stone.

13 recordsLinked to original sources
PubMed1984

Acute anuria and hypertension after left renal vein ligation: reversal after decompression of renal venous system.

Ligation of the renal vein in a patient with a solitary left kidney resulted in acute anuria and hypertension. These conditions were reversed by decompressing the renal venous system through anastomosis of the end of the left renal vein to the side of the splenic vein. After the anastomosis there was a decrease in renal size, a prompt diuresis, and a return of blood pressure to normal. Four months later, computerized tomography of the abdomen showed dilated renal and splenic veins and a slightly enlarged kidney; renal function was stable and the blood pressure was within normal limits.

Acute Disease↗
PubMed1982

Autosomal mosaicism in amniotic fluid cells from a twin pregnancy.

Amniocentesis was performed on a 39-year-old gravida 4 woman because of maternal age. Ultrasonography demonstrated a twin pregnancy, and two amniotic fluid specimens were obtained under direct ultrasound guidance. All cells analyzed from the first specimen were 46,XX. In the second specimen, one colony in each of two flasks had trisomy 9; the remaining 3 colonies analyzed were 46,XX. The total cell count in the second specimen was 14 (24%) of 58 cells which were trisomic for chromosome 9. The parents elected to continue the pregnancy, which resulted in two live-born infants, a male and a female, both chromosomally normal. The most likely explanation for the amniotic fluid finding is that fluid from one sac was sampled twice and that trisomic cells from the amnion were obtained during the second tap.

Adult↗
PubMed1976

Renal carbuncle: early diagnosis by retroperitoneal ultrasound.

The diagnosis of renal carbuncle has been prolonged from the time of onset of symptoms to the institution of treatment producing a significant rate of mortality. The use of retroperitoneal ultrasound is demonstrated as a noninvasive method for making an earlier diagnosis of renal carbuncle than has been afforded by more conventional means. This report illustrates the technique of nephrosonography and briefly reviews the medical and surgical approaches to this disorder. To our knowledge, this is the first reported case wherein ultrasound, and not pyelography, demonstrated a carbuncle without the aid of invasive arteriography.

Abscess↗
PubMed1976

Hypotomic cholangiography with glucagon.

Hypotonic cholangiography was performed with intravenous glucagon in 12 patients who demonstrated complete nonspecific obstruction of the distal common bile duct during postoperative T-tube or transhepatic cholanglography. In 8 cases (67%), a diagnostic result was obtained. Abolition of smooth-muscle spasm at the choledochal sphincter by glucagon-induced hypotonia appears to be a useful adjunct to roentgenography of the bile ducts.

Cholangiography↗
PubMed1975

Gray scale ultrasound diagnosis of obstructive biliary disease.

B-mode ultrasound examinations have been useful in demonstrating cholelithiasis and obstructive dilatation of the gallbladder. It is now possible with gray scale ultrasound technique to demonstrate dilatation of the common bile duct, as differentiated from the gallbladder, and also to show fluid containing spaces within the liver. Discrimination between solid and fluid filled intrahepatic structures is readily made, and dilated biliary radicles are frequently discernible.

Aged↗
PubMed1971

Antigenic and morphological similarities of progressive pneumonia virus, a recently isolated "slow virus" of sheep, to visna and maedi viruses.

Progressive pneumonia virus, the causative agent of a slow, pulmonary disease of Montana sheep, was shown to be antigenically related to two other slow viruses of sheep, visna and maedi. Electron microscopic examination of infected cells revealed that the virus matures by a budding process and that the budding particles as well as the mature, extracellular virions bear striking resemblances to the oncogenic ribonucleic acid (RNA) viruses. Recent findings of an RNA-dependent deoxyribonucleic acid polymerase associated with the virions of this group of slow viruses lend further support to the notion that they may tentatively be classified with the oncogenic RNA tumor viruses.

Animals↗
PubMed1971

Transformation of murine cells by two "slow viruses," visna virus and progressive pneumonia virus.

Visna and progressive pneumonia virus (PPV), two antigenically related, non-oncogenic "slow viruses" which have ribonucleic acid (RNA)-dependent deoxyribonucleic acid (DNA) polymerase activity, were examined for their ability to transform cells. Murine cells which had been exposed to either visna or PPV developed foci of altered, spindle-shaped cells 3 to 4 weeks after infection. Visna and PPV transformed lines were established from these cultures. There was no evidence that other oncogenic DNA or RNA viruses were involved in the observed transformation. Visna or PPV could be "rescued" from all transformed lines by co-cultivation with normal sheep testis cells. "Rescued" virus was identified as visna or PPV, and they retained the capacity to transform mouse cells. These experiments may have important implications in the understanding of both viral carcinogenesis and "slow" viral infections.

Animals↗
PubMed1971

Physical and biochemical properties of progressive pneumonia virus.

The physical and biochemical characteristics of progressive pneumonia virus were found to be remarkably similar to those of the ribonucleic acid (RNA) tumor viruses. Significant findings included the presence of a 60 to 70S RNA genome, RNA-dependent deoxyribonucleic acid polymerase activity, and common morphological properties. This information correlates with previously reported biological observations and supports the provisional inclusion of enveloped RNA-containing "slow viruses" within the RNA tumor virus group.

Animals↗
PubMed1970

Transformation of mouse macrophages by simian virus 40.

Studies were undertaken to prove that simian virus 40 (SV40) can transform the mouse macrophage, a cell type naturally restricted from deoxyribonucleic acid (DNA) replication. Balb/C macrophages infected with SV40 demonstrated T-antigen production and induced DNA synthesis simultaneously. In the absence of apparent division, these cells remained T antigen-positive for at least 45 days. SV40 could be rescued from nondividing, unaltered macrophages during the T antigen-producing period. Proliferating transformants appeared at an average of 66 days post-SV40 infection. Established cell lines were T antigen-positive and were negative for infectious virus, but yielded SV40 after fusion with African green monkey kidney cells. Their identity as transformed macrophages was substantiated by evaluation of cellular morphology, phagocytosis, acid phosphatase, beta(1c) synthesis, and aminoacridine incorporation.

Acid Phosphatase↗