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Biomedical subjects

L B Weinstock

Publications and source records attributed to L B Weinstock.

22 records · Page 2Linked to original sources
PubMed1980

Effect of osmotic diuresis on gentamicin-induced nephrotoxicity in rats.

The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin-induced histopathologic changes in renal tissue were examine in rats. Gentamicin (30, 60, 120, 160 mg/kg) was administered s.c. for 10 consecutive days with or without isosorbide pretreatment. Osmotic diuresis with isosorbide did not significantly reduce the dose-dependent extent of gentamicin accumulation in renal tissues in comparison to nondiuresed rats. Although the urinary concentration of gentamicin was reduced in the diuresed animals, total gentamicin excretion remained unaffected. In addition, diuresis altered neither the renal excretion of the proximal tubular cell marker enzyme, N-acetyl-B-glucosaminidase, nor the severity of pathologic damage as determined by light microscopic examination of renal tissues. It appears that osmotically-induced diuresis alone is insufficient to prevent or significantly reduce gentamicin nephrotoxicity in rats. This is in contrast to other forms of diuretic therapy, such as furosemide, which have been shown to effectively reduce renal accumulation and resultant renal toxicity of aminoglycoside administration.

Acetylglucosaminidase↗
PubMedDate not supplied

Endoscopic abnormalities of the anastomosis following resection of colonic neoplasm.

When 321 patients with resections for colonic neoplasms were prospectively evaluated for changes occurring at the anastomosis, eight different kinds were found (118 abnormalities seen in total). Inflammatory polyps, the most commonly observed abnormality (14.5%), may be misinterpreted as recurrent neoplasia by endoscopy. The majority of inflammatory polyps were discrete, 5- to 15-mm lesions, although diffuse nodularity was occasionally seen. Staples or sutures were visible at 11.3% of the anastomoses. Benign strictures, which developed in 7.1%, occurred primarily after left colonic resection with end-to-end anastomosis. Prominent vessels were occasionally seen at the anastomotic site (3.9%). Recurrent carcinoma at the anastomosis was found in 6 of 116 patients with Dukes B and C tumors (5.2%) and occurred 0.4 to 2.0 years after surgery (mean, 1.2 years). Recurrent carcinoma appeared as ulcerated submucosal lesions, bulky luminal masses, and polypoid lesions. In two patients, mucosal erythema, edema, and friability at the anastomosis were the only endoscopic evidence of underlying carcinoma.

Anastomosis, Surgical↗