A series of enzyme electrodes for measurement of glucose have been constructed. The electrodes contain glucose oxidase immobilized on platinum, either with or without co-immobilization of catalase. When placed in buffered glucose, the enzyme electrodes show a potentiometric response to glucose with respect to a Ag/AgCl reference electrode. This response is reproducible in the physiologic range of glucose concentrations. The immobilization technique, some of the environmental variables such as oxygen concentration and pH, and several compounds that might interfere with the selectivity of the enzyme electrodes for glucose have received preliminary study. This direct potentiometric approach is undergoing further evaluation to determine the basic electrochemical mechanism responsible for the potentiometric signal and whether it can be adapted for continuous in vivo monitoring of the glucose concentration in body fluids.

Blood Gas Analysis↗

PubMedDate not supplied

Possibility for an immobilized flavin fuel cell electrode for glucose measurements.

Preliminary work is described on the attachment of riboflavin to solid carbon via a coupling group that should provide a pathway for easy electron transfer. Such an approach, when extended to the flavin cofactor portion of glucose oxidase, has the possibility of forming a fuel cell electrode of high specificity for glucose and in which the current would be related to the concentration of glucose.

Blood Glucose↗

PubMedDate not supplied

Applications of immobilized biochemical systems in India and other developing countries.

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Developing Countries↗

PubMedDate not supplied

Electrochemical applications of immobilized enzymes: energy transfer.

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Electrochemistry↗