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L B Zubzhitskaia

Publications and source records attributed to L B Zubzhitskaia.

4 recordsLinked to original sources
PubMed1993

[Morphology of the placenta in genital mycoplasmosis].

96 placentas from mothers with genital mycoplasmosis diagnosed during the pregnancy (main group), and without mycoplasmosis (group for comparison) were studied. Histological study was performed in parallel with electron microscopy of the amnion and use of fluorescent antibodies. Progression of the involutive-degenerative changes in the placenta with the development of lipophanerosis and destruction of the extra-placental amnion epithelium were observed in the main group in parallel with the increase of the immunoglobulins studied (A, M, G), fibrinogen, C3-component of the complement with fixation of pathogenic immune complexes (IC). IC are observed in the placenta of 51 +/- 6.35% and in the extra-placental coats in 100% of mothers with mycoplasmosis versus 9 +/- 4.91% and 40%, respectively, in the comparison group. The presence of IC in the placenta and extra-placental coats correlates with the neurological symptoms in newborns and the increase of infectious-allergic diseases in children of the 1st year of life.

Antigen-Antibody Complex↗
PubMedDate not supplied

[Electron microscopic and immunomorphologic study of the placenta in genital mycoplasmosis].

Peculiar ultrastructural features allowed the authors to reveal M. Homminis corpuscles in placental tissues of women with genital mycoplasmosis. Mycoplasma was found in the amniotic epithelium, chorionic plate, in the lumen of villous capillaries, this showing possible hematogenic way of the infection from mother to fetus. In the placenta of women with genital mycoplasmosis immunopathological processes develop in association with formation of pathogenic immune complexes (PIC) that are fixing the C3 complement fraction. Location of PIC on the syncytiotrophoblast membranes and vascular endothelium causes immunological inflammation with the involvement of immunocompetent cells resulting in the destruction of syncytial membranes and membranes of the placental barrier. Damage to the placental barrier membranes promotes the development of placental failure, a complicated course of pregnancy and delivery, deterioration of the state of the fetus and newborn infant.

Adult↗