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L Barajas

Publications and source records attributed to L Barajas.

86 records · Page 5Linked to original sources
PubMed1971

Renin secretion: an anatomical basis for tubular control.

By means of electron microscopy of serial sections and three-dimensional reconstruction of the juxtaglomerular apparatus a quantitative study has been made of the distribution of the areas of contact between the tubular and vascular components. Of the two arterioles the efferent is the only one consistently in contact with the distal tubule. The extraglomerular mesangium is also in contact with the distal tubule in all the apparatuses examined. Two morphologically distinct types of contact are described; one is thought to be permanent and the other reversible. An analysis of the cells of the juxtaglomerular apparatus for their position, granularity, and contact has revealed that the majority of granular cells are not in contact with the distal tubule. The anatomical findings are integrated in a model of the control of renin secretion based on variations in contact between the elements of the juxtaglomerular apparatus.

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PubMedDate not supplied

Immunoelectron microscopy of epidermal growth factor in mouse kidney.

We recently have reported the immunolocalization of epidermal growth factor (EGF) in mouse kidney by light microscopy. In the present study, we have investigated the ultrastructural localization of EGF by the preembedding immunoperoxidase method for electron microscopy. EGF immunoreactivity was present on the apical plasma membrane of the cells of the thick ascending limb of Henle and the distal convoluted tubule. The macula densa, by contrast, lacked immunoreactivity. Based on functional evidence, a possible regulatory role for EGF in the membrane transport in the distal nephron has been suggested.

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