[Description of an atypical case of dermatomyositis with lambda IgG paraproteinemia associated with a neoplasm of difficult diagnosis].
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Biomedical subjects
Publications and source records attributed to L Baratta.
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Research has been made on the progesterone-induced effects upon endometrium on impuberal rats (either intact, or castrated, or castrated and adrenalectomized, or hypophysectomized) after an acute or a protracted treatment, which were made every third hour all through the day. It resulted that the hormone basically shows two distinct activities. The first one causes a modest awakening of the anabolical functions both in the lining and in the glandular epithelia, which results in the building up of small amounts of lipid and glycogen. The second one involves the lamina propria as well, and brings about morphological effects which can be superposed on those induced by estrogens. The former seems an autonomous activity and can mainly be found after long-lasting treatments. The latter, on the contrary is influenced by the administration time and can be detected only during a.m. treatments whereas it cannot be detected during p.m. and night treatments. Besides it is influenced by the hypophysal activity and in particular by gonadotropins. The possible mechanism of these influences are discussed.
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An assessment was made of the usefulness of continuous dynamic ECG (CDE) in diagnosis of the sick sinus syndrome (SSS). It was found that CDE has the following advantages: ready repeatability; control of patients during such physiological activities as sleep; recording of the possibly fleeting and intermittent pathological episodes that characterise SSS. The conclusion is drawn that CDE is the soundest technique for the investigation of SSS, whereas electrophysiological examination, albeit complementary, could be limited to cases whose interpretation proves more difficult.
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We have assessed the value of echocardiographic measurements of left ventricular dimensions, as compared to the standard angiographic calculations, in patients (pts) with mitral regurgitation (MR). Of 126 such pts who had undergone echocardiography and cardiac catheterization, 57 were excluded because of associated congenital cardiac malformations, additional significant valvular disease(s) and technically unsatisfactory echocardiographic study. Of the remaining 69 pts, 24 had rheumatic MR (14 with associated mild stenosis); ischemic heart disease was the cause of MR in 1 pts; myxomatous degeneration was found in 12 and congestive cardiomyopathy in 7. The pts were further subdivided in 3 groups according to the severity of MR. Although in all groups echocardiography consistently underestimated left ventricular volumes, there was a statistically significant correlation for end-diastolic volumes, end-systolic volumes and stoke volumes in all three groups. The best correlation was obtained in the calculation of ejection fraction (r = 0.87; P less than 0.001 in mild MR. r = 0,82; P less than 0,001 in moderate MR. r = 0,81; P less than 0,001 in severe MR). The measurement of left ventricular volumes by M-mode echocardiography is generally unsatisfactory in patients with MR. The echo-calculated ejection fraction however, appears to be reliable.
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The study concerns the action of dehumidified or humidified gas on the pulmonary lining layer. The results of our research suggest that water vapor used in artificial ventilation may be an important determining factor of the respiratory problems reported by clinicians in man. Important modifications of the lining layer of the alveolar epithelium occur, accompanied by more important alterations, including those of the content of the alveolus, all of which contribute to the pulmonary edema observed.
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Using electron microscopy we have examined the lining layer of the rat pulmonary alveolus. This layer appears as a morphological entity 1-3 days after birth: it is composed at first of a filamentous Ruthenium Red-negative material derived from lamellar bodies, and subsequently (4 days after birth) of a homogeneous Ruthenium Red-positive material. This latter material, which corresponds to the epithelia lining of the alveolus typical of adult rats, is presumably derived from a mixture of the filamentous material produced by the lamellar bodies, and a material produced by the alveolar cells 4 days after birth which contains acidic groups which bind Ruthenium Red.