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Biomedical subjects

L Barber

Publications and source records attributed to L Barber.

65 records · Page 4Linked to original sources
PubMed1988

Pseudoureteroceles following extracorporeal shock wave lithotripsy.

Routine follow-up urography demonstrated pseudoureteroceles caused by impacted calculus fragments in the distal portion of the ureter in five patients who had undergone extracorporeal shock wave lithotripsy of renal calculi 4-6 weeks before. Although all five patients showed some degree of obstruction at the time of follow-up urography, four were asymptomatic. Either small isolated fragments (two patients) or a column (steinstrasse) of fragments (three patients) was responsible for the abnormality. Two patients required further intervention to relieve the obstruction.

Adult↗
PubMed1983

Effect of vibration on tactile sensitivity.

Tactile hypersensitivity is a common sequela of traumatic hand injury. Vibration is used clinically to reduce this hypersensitivity. The purpose of this study was to determine if vibration has an effect on tactile threshold and if so to determine the duration of that effect. Mean tactile thresholds were determined for 24 healthy adults by means of a pressure aesthesiometer. The experimental group (6 men, 6 women) received 10 minutes of vibration. Mean tactile thresholds were redetermined at the end of the 10-minute treatment period in the experimental group and after a 10-minute rest period in the control group (6 men, 6 women). Thresholds were also redetermined at 5-minute intervals for the next 20 minutes in all subjects. The experimental group showed a significant change in mean tactile threshold after 10 minutes of vibration (p less than .001). This difference remained at 5 (p less than .001) and 10 (p less than .05) minutes postvibration but not at 15 and 20 minutes. No significant change in mean tactile threshold was found in the control group. The results indicate that vibration does increase tactile threshold in "normal" hands and the effect lasts for at least 10 minutes. The application of this information to the clinical setting is discussed.

Adult↗
PubMed1973

Enzymes of the gamma-glutamyl cycle in the ciliary body and lens.

The enzymes of the gamma-glutamyl cycle have been found in rabbit ciliary body and, except for 5-oxoprolinase, also in the ocular lens. Histochemical studies show that gamma-glutamyl transpeptidase is localized mainly in the basal portions of the epithelial cells of the ciliary body; the findings are similar to those observed in the chloroid plexuses. The histochemical staining reaction in the ciliary epithelium is more intense than in the chloroid plexus, intestine, and kidney. gamma-Glutamyl transpeptidase staining activity in the epithelium of the intestinal and renal proximal convoluted tubules is confined to the microvillus border. Moderate transpeptidase activity was found in the cytoplasm of nonpigmented epithelial cells of the iris at the posterior pupillary margin. The histochemical and enzyme activity studies are consistent with the thesis that the gamma-glutamyl cycle functions in transport of amino acids across the blood-aqueous humor barrier.

Acyltransferases↗
PubMedDate not supplied

Canine hemangiosarcoma treated with standard chemotherapy and minocycline.

Standard treatments for canine hemangiosarcoma include surgery and chemotherapy with doxorubicin, but in spite of treatment most dogs with this disease die within 6 months of diagnosis. Tumor growth and metastasis are angiogenesis dependent. Antiangiogenic drugs such as minocycline may provide therapeutic benefits in cancer patients. The purpose of this prospective study was to evaluate the efficacy of chemotherapy with doxorubicin and minocycline, an antiangiogenic agent, in dogs with hemangiosarcoma. Eighteen dogs with histologically confirmed hemangiosarcoma of any stage were treated with doxorubicin, cyclophosphamide, and minocycline. Complete staging was performed before and during the treatment period to assess remission status and response to therapy. No statistically significant difference was found in survival between the dogs treated with chemotherapy and minocycline, and historical controls consisting of dogs that received chemotherapy alone. Postmortem examination revealed widespread metastasis, suggesting that minocycline is ineffective as a single antiangiogenic agent in canine hemangiosarcoma.

Angiogenesis Inhibitors↗