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Biomedical subjects

L Basurto

Publications and source records attributed to L Basurto.

6 recordsLinked to original sources
PubMed2001

Hormone replacement therapy increases ACTH/dehydroepiandrosterone sulfate in menopause.

OBJECTIVE: To demonstrate that hypoestrogenism in menopause is in part responsible for the decrease in circulating dehydroepiandrosterone sulfate (DHEA-S) and ACTH levels. To test this hypothesis, 25 postmenopausal women aged 47-60 years, were given orally conjugated equine estrogen (CEE) to study the effect on circulating DHEA-S, cortisol and ACTH. DESIGN: A prospective, non-blinded study was performed. Hormonal levels were analyzed before and after three cycles of CEE 0.625 mg/day for 21 days followed each by chlormadinone acetate for 5 days. RESULTS: Low baseline levels of DHEA-S increased significantly after HRT (1.71+/-0.75 to 3.3+/-1.5 micromol/l, (P<0.001). ACTH levels augmented moderately from 3.26+/-1.4 to 4.7+/-1.8 pmol/l (P<0.05) and cortisol from 350.4+/-118 to 450.8+/-144 nmol/l (P<0.01). A positive correlation was obtained between 17 beta-estradiol and ACTH (r=0.48), estradiol and cortisol (r=0.52) as well as estradiol and DHEA-S (r=0.60). In addition, the correlation was highly significant (P<0.001) between ACTH and DHEA-S at the term of HRT. CONCLUSION: HRT increased DHEA-S, ACTH and cortisol concentrations, which may suggest that this therapy may exert a stimulatory effect on the pituitary gland when baseline hypoestrogenism is present, but further studies are required to clarify the mechanism underlying this process.

Adrenocorticotropic Hormone↗
PubMed2000

[Effectiveness of acarbose in the control of glucose tolerance worsening in pregnancy].

Gestational diabetes is considered as a carbohydrate intolerance, first diagnosed during pregnancy. A previous stage of carbohydrate impairement may precede its abnormality; therefore it may be convenient to establish some management in order to avoid the gestational diabetes. Six pregnant women who had moderate elevated level of blood glucose at fasting and postprandial were treated with acarbose, alpha-glucosidase inhibitor agent, given three times a day before meals. In all patients fasting and postprandial glucose levels were normalized; pregnancies went uneventful and the newborns were considered normal. Acarbose was associated with intestinal discomfort which persisted during the whole pregnancy.

Acarbose↗
PubMed2000

[Circulating leptin doesn not change in postmenopausal women receiving replacement therapy with tibolone].

After informed consent, blood samples were obtained to measure leptin, FSH, LH, insulin, 17-beta-estradiol, and IGF-1. No differences in serum leptin was observed between the women on Tibolone (8.1 +/- 4.2 ng/mL) and the control group (7.4 +/- 3.7 ng/mL). Women on Tibolone had lower insulin levels (16.4 +/- 1.8) than women without therapy (19.4 +/- 1.3 mU/mL) (p < 0.05). On the contrary IGF-I levels were elevated (150.0 +/- 16.4) as compared with those in non-treated women (121.0 +/- 13.4 ng/mL) (p < 0.05). Body weight was similar between the two groups. From these data it is concluded that Tibolone, as replacement therapy, does not increase circulating leptin and seems to have no effect on body weight.

Aged↗
PubMedDate not supplied

[Osteoporosis in males is a frequently overlooked risk].

For many years, osteoporosis has been considered as a women's disease. Data show that the incidence of this bone thinning disease is high in men. Aging is accompanied with changes in circulating hormone levels. Thus, low testosterone levels is associated with osteoporosis in men. Like osteoporosis in females, in men, might be treated with calcium supplements, vitamin D and bisphosphonates. Recent report of treatment for osteoporotic men with bisphosphonate alendronate was successful in improving bone density at several sites in the male skeleton, in reducing the incidence of fractures and in preventing loss of height. The benefits and risks of hormone androgen replacement therapy in men are not fully defined, but the androgens supplementation is also expected to have favorable consequences on bone.

Age Factors↗
PubMedDate not supplied

[Decrease in circulating androgens in men during senescence].

It has been reported that circulating androgens exhibit a decrement with aging in men; however, there are some controversial results. We have carried out a descriptive study in a group of men aged 60-70 years. In order to determine levels of androgens In serum, the results were compared with those obtained in another group in normal men 20-44 years of age. Measurements included circulating levels of testosterone(T), dehydroepiandrosterone sulfate (DHEA-S), LH, FSH, estradiol (E), ACTH, prolactin (PRL), IGF-1, and SHBG. The group of older men group showed a significative decrement of T and DHEA-S, as well as E. An increment of FSH and LH without changes of ACTH, cortisol and SHBG was demonstrated. Collaterally, PRL and IGF-1 decreased in aging men. The present data demonstrated a significant decrement of circulating androgens, both T and DHEA-S coinciding with elevation of gonadotropins. It is concluded that aging is accompanied by changes of a decrement of androgens, of gonads, and adrenal origin. Further studies will investigate the effect of testosterone replacement in aging men.

Adult↗