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Biomedical subjects

L Bell

Publications and source records attributed to L Bell.

At least 127 records · Page 7Linked to original sources

Evaluation of an automated procedure for primary screening of hyperlipoproteinemias.

An automated procedure for the determination of beta-plus-pre-beta-lipoprotein cholesterol is described and evaluated for mass screening of hyperlipoproteinemias. It is shown that this method fulfills the requirements for an ideal method for primary screening: it can be used in non-fasting samples, is capable of detecting hyperlipoproteinemias characterized by both cholesterol and/or triglyceride abnormalities, is fast, accurate and extremely inexpensive. Evidence is shown that the method is extremely useful for primary screening and, when tested in a coronary screening detection program, gave only 4% false positive and 3.4% false negative results.

Autoanalysis↗

Effect of exercise on lipid metabolism of rats fed high carbohydrate diets.

Two experiments were conducted to determine whether high carbohydrate diets or exercise would have a greater influence on certain parameters of lipid metabolism. Male Fischer rats were used in both experiments, separated into exercise and sedentary groups, and fed either a high sucrose (63%) or a high starch (63%) diet. There were no differences in body weight or food consumption between the two diets. Exercise resulted in a highly significant increase in food consumption in both experiments. Rats fed sucrose had a higher serum cholesterol value than rats fed starch. Diet did not influence serum triglycerides but the rats on excercise had significantly lower serum triglycerides than the sedentary rats. Liver weight was significantly larger in rats fed sucrose. Sucrose caused an increase in the activity of both glucose-6-phosphate dehydrogenase and malic enzyme activities in liver tissue, whereas exercise caused an increase in the activity of these enzymes in adipose tissue.

Adipose Tissue↗

Metabolic effects of exercise. I. Effect of exercise on serum lipids and lipogenesis in rats.

To evaluate the metabolic effects of exercise, three groups of exercised male rats were compared to their sedentary controls at the end of 10 wk of voluntary exercise in rodent activity cages. Exercises rats consumed more food than sedentary rats but had greater weight gain only at the higher levels of activity. Exercised rats had significanlty lower serum triglycerides and higher values of adipose tissue alpha-glycerophosphate dehydrogenase activity. At higher levels of physical activity, the exercised rats enhibited larger adrenal glands and lower values of hepatic glucose-6-phosphate dehydrogenase. It is concluded that specific levels of voluntary exercise are needed to achieve specific metabolic effects.

Adipose Tissue↗

A new mutation at the cmd locus in the mouse.

A short limb dwarfing syndrome that arose in BALB/cGaBc inbred mice appeared to segregate as a Mendelian autosomal recessive lethal mutation. Anatomical and histological studies of newborns showed shortening and widening of most cartilaginous bones, shortening of the head, subcutaneous edema, and engorgement of liver with blood. Cartilage showed deficiency of acid mucopolysaccharide in the extracellular matrix and strain excessively for collagen. The primary cause of death at birth is probably the extremely compressed anterior thorax. The new mutation behaves as an allele of cartilage matrix deficiency (cmd) and is provisionally named cmdBc.

Animals↗

Evaluation of kinetic therapy in the prevention of complications of prolonged bed rest secondary to stroke.

We performed a prospective, controlled study of kinetic therapy in acute, severe stroke. This therapy involved continuous mobilization of a bedridden patient by means of a specially designed rotating bed. All patients with acute stroke presenting to the Neurology Service over an 18-month period were screened, and those that qualified were assigned to confinement in either a routine hospital bed or a rotating bed. We found that the most common complication of stroke with bed confinement of 4 days or longer was bacterial infection consisting of either pneumonia, sepsis, or urinary tract infection. The two variables found to be of greatest significance in affecting the rate of infection were length of bed confinement, especially for greater than 13 days (2.3-fold increased risk, p less than 0.04), and placement in a routine hospital bed (2.9-fold increased risk, p = 0.023).

Bed Rest↗

Coccygeal muscle injury in English Pointers (limber tail).

A condition colloquially referred to as "limber tail" and "cold tail" is familiar to people working with hunting dogs, primarily Pointers and Labrador Retrievers. The typical case consists of an adult dog that suddenly develops a flaccid tail. The tail either hangs down from the tail base or is held out horizontally for several inches from the tail base and then hangs straight down or at some degree below horizontal. Initially, the hair on the dorsal aspect of the proximal tail may be raised and dogs may resent palpation of the area 3-4 inches (8-10 cm) from the tail base. Most dogs recover spontaneously within a few days to weeks. Anecdotal reports suggest that anti-inflammatory drugs administered within 24 hours after onset hasten recovery. Less than one half of affected dogs experience a recurrence. Affected Pointers almost always have a history of prolonged cage transport, a hard workout the previous day, or exposure to cold or wet weather Most owners and trainers familiar with the condition do not seek veterinary assistance. In cases where people are not familiar with this disease, other conditions such as a fracture, spinal cord disease, impacted anal glands, or prostatic disease have been incorrectly diagnosed. We examined 4 affected Pointers and found evidence of coccygeal muscle damage, which included mild elevation of creatine kinase early after onset of clinical signs, needle electromyographic examination showing abnormal spontaneous discharges restricted to the coccygeal muscles several days after onset, and histopathologic evidence of muscle fiber damage. Specific muscle groups, namely the laterally positioned intertransversarius ventralis caudalis muscles, were affected most severely. Abnormal findings on thermography and scintigraphy further supported the diagnosis.

Animals↗