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Biomedical subjects

L Beraneck

Publications and source records attributed to L Beraneck.

At least 19 recordsLinked to original sources
PubMed1998

Two cases of discitis due to Propionibacterium acnes.

We report two cases of discitis due to Propionibacterium acnes and review previously published cases of bone and joint infections in which this organism was recovered as a pure culture. P. acnes is an anaerobic organism usually considered a normal inhabitant of the skin but capable of producing a variety of infections including discitis, osteitis, arthritis, and chest wall osteitis. Most patients were immunocompetent. A few infections occurred spontaneously, whereas others were secondary to a break in the skin or to implantation of foreign material into the body for instance during internal fixation of a fracture or arthroplasty. Cases of P. acnes chest wall infection have been reported in patients with palmoplantar pustulosis or chronic or multifocal osteitis, supporting a role for P. acnes in SAPHO syndrome.

Adult↗
PubMed1995

Hypophosphatemic osteomalacia with plantar neurilemoma. A review of the literature (100 cases).

A case of hypophosphatemic osteomalacia with recovery after removal of a plantar neurilemoma is reported. One hundred cases of osteomalacia with a connective tissue tumor were found in the medical literature. Both sexes and all age groups were affected. Patients often had severe osteomalacia with decreased serum 1,25 (OH)2 vitamin D and phosphate levels and renal phosphate wasting. These abnormalities resolved immediately after complete excision of the tumor, which was often a small lesion found after the diagnosis of osteomalacia. Of the 100 tumors, 87 were benign and half were vascular (e.g., hemangiopericytoma, hemangioma, angiofibroma). A large number of tumors could not be readily classified because they contained vascular structures, giant cells, spindle-shaped cells, and cartilage. Many other histologic variants were observed, including giant cell tumors, nonossifying fibromas, cartilaginous tumors, and osteosarcomas. The tumor was usually located in a limb, generally a lower limb, and was skeletal in nearly half the cases. The tumors produced one or more substances with a capacity for blocking intracellular phosphate transfer and inhibiting renal tube 1 alpha hydroxylase. The link between these two abnormalities remains unclear.

Foot Diseases↗
PubMed1992

[Chronic sarcoidosis-polyarthritis with infantile onset. Persistent synovial granulomas under corticotherapy].

The case of a patient who developed sarcoidosis with chronic joint symptoms at the age of four and still has active disease twenty years later despite three years of corticosteroid therapy is reported. During the course of the disease, specific histologic features of sarcoidosis were evidenced twice in synovial specimens, twice in skin biopsy specimens, and once in bronchial tissue. Deformations and joint lesions developed in the hands and feet. The combination of arthritis, skin lesions, and uveitis occurs both in juvenile-onset sarcoidosis and in chronic juvenile joint diseases, raising significant diagnostic problems which can be solved by histologic studies of synovial or skin biopsy specimens.

Adrenal Cortex Hormones↗
PubMed1987

[Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey. 85 cases].

The authors report the data collected by a national investigation organized by the French Society of Rheumatology, concerning the osteo-articular manifestations of severe acne, palmo-plantar pustulosis and primary thoracic and peripheral hyperostosis. This investigation collected 85 case-reports including 13 severe acne, 44 PPP and 28 hyperostosis without the dermatitis mentioned above. From this investigation, it appears that dermatological and osseous pictures described under various denominations, present common characteristics and transition forms justifying their common study under the acronym SAPHO (Syndrome Acne-Pustulosis-Hyperostosis-Osteitis). The bony involvement, especially anterior thoracic, but also vertebral and even peripheral seems to be the common denominator between these diseases. It realizes a true rheumatoid inflammatory osteitis, osseous counterpart of synovial and cartilagenous affections in inflammatory rheumatoid diseases. This group has rather loose connections with common psoriasis and slightly more definite relationships with primary ankylosing spondylarthritis. These clinical and immunogenetic connections occur also through bony involvement.

Acne Vulgaris↗
PubMed1986

[Pyrithioxin and rheumatoid polyarthritis].

After reviewing the literature, the authors demonstrate that pyrithioxine is active in rheumatoid arthritis. The effectiveness is marked by a 50 per cent reduction in the articular index in 59.7 per cent of cases, a reduction in the duration of morning stiffness in 49 per cent of cases, a decreased erythrocyte sedimentation rate in 52.4 per cent of cases and a statistically significant decrease in the mean of these parameters in relation to the mean value at the beginning of treatment. The good results were considered to be those cases in which two of the three criteria (articular index, morning stiffness and erythrocyte sedimentation rate) were decreased by at least 50 per cent. Secondary escapes from treatment (13 per cent) and suspension of treatment for intolerance were considered to represent treatment failures. A good result was obtained in 42.7 per cent of cases. Side effects were observed in 40.1 per cent of cases and were responsible for suspension of treatment in 22.8 per cent of cases. Half of the side effects consisted of muco-cutaneous reactions which generally appeared early and were benign. Haematological, renal and gastrointestinal effects and aguestia occurred more rarely. However, a number of patients died as a result of agranulocytosis, hepatitis or extramembranous glomerulonephritis.

Agranulocytosis↗
PubMed1984

[Multiple hyperostosis with unilateral sacroiliitis. A new spondyloarthropathy].

Six patients (4 male and 2 female) presenting with an original, predominantly osseous disease are reported. The disease is characterized by a chronic inflammatory process affecting the thorax, the spine, the femur in 1 case and in all patients only one of the sacro-iliac joints. The condition had begun 11 to 28 years previously and had been active for 6 to 24 years. One case started with regressive polyarthritis. There was no visceral involvement. Radiograms showed bone condensation with hyperostosis, sometimes hypertrophic, unrelated to any articular space. Depending on each patient, the lesions involved the clavicles, the sternum, the posterior arch of the ribs, the vertebrae, the inferior femoral metaphysis. The only joints involved were the sacro-iliac and anubrio-sternal joints. The areas affected showed high radioisotope uptake. There was discrete biochemical inflammatory syndrome. Three of the 6 patients belonged to the HLA group B 27. The multiple biopsies performed showed no specific lesions. The disease proceeds by successive attacks lasting several months and responding poorly to anti-inflammatory drugs. One patient developed Crohn's disease, another, retroperitoneal fibrosis. In some respects, this condition is remindful of sterno-clavicular hyperostosis and of the osteo-arthropathy in palmoplantar pustulosis or acne conglobata. It seems to constitute a new variety of spondylo-arthropathy intermediate between the above-mentioned diseases and genuine ankylosing spondylitis.

Adolescent↗
PubMed1983

[Sterno-costo-clavicular hyperostosis. Apropos of a case. Review of the literature].

The authors report a case of sterno-costo-clavicular hyperostosis. Since Kohler's first description in 1975, 15 observations have already been reported. The disease consists in a painful swelling of the clavicles, sternum and upper anterior ribs. On roentgenograms these bones are enlarged and show increased density. Bone scan shows markedly increased uptake. Phlebography shows subclavian vein occlusions. Histological examination demonstrates hyperostosis without osteoclasis as in Paget disease.

Bone Diseases, Developmental↗