Biomedical subjects
Publications and source records attributed to L Bidzan.
To overcome diagnostic uncertainties in early phases of Alzheimer's disease (pre-senile dementia), the analysis of T-3 and T-4 concentration can be usefully employed. Arising out of the localisation neuropathological findings in Alzheimer type dementia, it could be that hormonal findings perform a useful function as indicators of a change in neurotransmitter activity in this disease.
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The study proposes an evaluation of one of the parameters of psychological time--the rhythm of time--established by simple experimental methods. 43 persons were studied. The results obtained show that there are differences between persons with psychopathological symptoms and healthy group.
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Basal serum cortisol level was measured in patients with primary degenerative dementia. The diagnosis of primary degenerative dementia was made by the DSM-III-R criteria, and the severity of dementia was measured by use the Rosen et. al. scale. Additionally, the presence of depressive and paraphrenia syndromes was evaluated. The Hamilton scale was used for the evaluation of depression severity. Cortisol level was measured by radioimmune assay. Sixty three patients, 39 female and 24 male, were evaluated. The mean age for women was 69.54 and for men 71 years. Patients were divided into 3 groups: I--simple dementia, II--dementia with depression, III--dementia with paraphrenia. Positive correlation was found between basal cortisol level and the severity of dementia only in group I. Mean cortisol level in patients from group II and III was significantly different than in group I. Among female patients with depression the negative correlation between cortisol level and severity of dementia was found; no other correlations were proved. No correlation was found between the cortisol level and severity of dementia in Hamilton's scale.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A case-control study was conducted on 90 cases of "probable" Alzheimer's disease and 97 controls at the same age as patients with dementia of the Alzheimer type. The patients were diagnosed according to the DSM IIIR criteria. Information was obtained on birth and childhood, medical and surgical history, exposure to various social, psychological and biological factors, family history of dementia. A structured questionnaire was based on AMDP-system. Some of the variables studied reached statistical significance: first of all unfavourable factors (especially poor livelihood) taking place during the person's childhood, the level of education and social activity. Family history of dementia among persons with Alzheimer type dementia also reached statistical significance. Head trauma was more frequent in patients with dementia, but the differences were not significant. The findings suggest a possible etiologic role for some environmental factors in dementia of the Alzheimer type.
A case-control study was conducted on 16 cases of probable Alzheimer's disease and 32 controls matched for age. The first control group was younger while the second was at the same age as patients with dementia of the Alzheimer's type. The patients were diagnosed according to DSM IIIR criteria. Information was obtained on birth and childhood, medical and surgical history, exposure to various social, psychological and biological factors as well as a family history of dementia. A structured questionnaire based on the AMDP--system was completed. Some of the variables studied reached statistical significance. First of all the sum of unfavourable environmental factors taking place during the person's childhood and elderly was predictive. Also head trauma was more frequent in patients with dementia. The findings suggest a possible etiologic role for some environmental factors in dementia of the Alzheimer's type.