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Biomedical subjects

L Bignardi

Publications and source records attributed to L Bignardi.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Concerning the morphology of the supraglottic submucosa and its relation to the growth of cancer (author's transl)].

The histological structure of the supraglottic submucosa consists of a wide-mesh connective net, which builds compartments where glands are included. Somewhere, the walls of compartments are so thick that they may be considered as true ligaments. Some of them are located at the limit between glottis and supraglottis; therefore one may argue that the so-called "biological vallum", which hinders the downward propagation of supraglottic cancers is not only due to the interruption of lymph ways between vestibulum and vocal chords but also to the presence of this thick connective barrier. Two gaps interrupt the continuity of the barrier, the first one at the anterior commissure, the second at the posterior extremity of the ventricle. The situation of the gaps corresponds to the main directions of propagation of the supraglottic cancers, when they spread inferiorly.

Humans↗
PubMed1975

Short dialysis schedules (SDS)--finally ready to become routine?

One hundred and one patients were treated for up to two years for three hours every other day (10.5 hr/week), or four hours thrice-weekly with conventional disposable 1m2 dialysers have been investigated. Rigorous control of water balance and the maintenance of predialysis serum K and PO4 within normal limits were the main criteria for judging the adequacy of the treatment. The results regarding blood pressure, phosphate problems, haematocrit, peripheral nerve status, pericarditis and range of rehabilitation are discussed.

Adolescent↗
PubMedDate not supplied

Morphological study of the laryngeal anterior commissure with regard to the spread of cancer.

This morphological study, done on larynges from male cadavers from 40 to 60 years of age, sectioned horizontally and dye-stained, shows that in the anterior commissure, at the level of the upper surface of the vocal cords, there is a structure which could be of cancerological interest, termed the X-space by the authors. This structure, 1.5-2.0 mm long, is composed of a homogeneous layer of dense fibrous connective tissue located between the dihedral angle of the thyroid cartilage and the laryngeal mucosa. Vascular and glandular formations penetrate the segments above and below this point, making the connective layer less homogeneous. As the X-space is a point of greater resistance to the deep spread of the tumor, the dissemination of cancer at this level is more likely to occur along the mucosa: this allows the surgeon to ascertain the exact margins of the tumor.

Adult↗
PubMedDate not supplied

[Oral and i.v. iron therapy in haemodialysis patients (author's transl)].

Low serum iron level with a transferrin saturation below 16% is a crucial aetiologic factor of anaemia in haemodialysed patients. Current therapy usually is a correct dialytic and dietetic treatment and i.v. iron supply. Two groups of haemodialysis patients with low serum iron but a normal transferrin saturation, have been studied by comparing the efficacy of the i.v. and the oral iron supply. The serum iron of the two groups changed from low to normal level with highly significant difference. Haemoglobin and haematocrit did not change because of the normal transferrin saturation before the treatment. In conclusion, in uraemic patients treated by chronic dialysis, the oral and the i.v. iron therapy probably give the same result.

Administration, Oral↗
PubMedDate not supplied

Preliminary results obtained with short dialysis schedules.

The results regarding the treatment of 55 patients, 6 of them treated for, at least 10 months, with 1 sq. meter disposable dialyzers and a dialysis strategy of 3 hours every other day or 4 hours trice weekly have been presented. Clinical indexes especially regarding erythropoiesis and peripheral nerve status will be discussed. Th results show that this new method of treatment is feasible and may become in the future a routine strategy for chronic intermittent dialysis.

Adult↗
PubMedDate not supplied

[Suprahyoid transpharyngeal approach to the median skull base in surgery of rhinoangiofibroma].

Ten young males with rhinopharyngeal angiofibroma (RAG) were studied. Except for one case of IIIb stage the others were all either I or IIIa. They all underwent surgery at the E.N.T. Clinic in Ferrara employing the transpharyngeal suprahyoid approach (TSA) originally described by Bocca. For the one case in the most advanced stage (IIIb), besides the TSA a paralateronasal approach and a complementary RT were also planned. In this series of cases, one recurrence due to a peritubaric residue was treated 8 months later through a transpalatal approach. The follow-up, with NED findings, varied from a maximum of 12 to minimum of 2 years (average 6.4 years), except for the last subject which underwent surgery in 1991. Three minor post-operative complications due to TSA were encountered, while 1 complication was attributed to the transpalatal approach used for the recurrence described. All cases healed completely. The data on the TSA from the international and national literature is reviewed underlining that the negative elements reported have, in the authors' opinion, been overcome by: perfecting the method for RAG exeresis and the method of the tracheotomy; making technological improvements: pre-operatory embolization, microsurgery applied to TSA in order to check any lateral branches and to the transnasal approach in order to check any residue in the choanal area.

Adolescent↗
PubMedDate not supplied

[Subtotal reconstructive laryngectomy: author's experience].

The authors conclude 18 year's experience with reconstructive laryngectomy by adopting two surgical techniques for intrinsic laryngeal tumors. The first, where one or both of the arytenoids are conserved, can be applied in cases of supraglottic neoplasms extending to the glottis as well as in glottic cancers where a simple cordectomy is not feasible. In both cases this technique is indicated when at least one arytenoid is respected. The second technique involves removal of both arytenoids and is used in cases of intrinsic supraglottic or glottic tumors extended to both arytenoids. The anatomic-pathological criteria supporting these techniques are: 1) the presence of a fibrous ligament anterior to the arytenoid vocal process. This makes possible proper exeresis within healthy tissue (as can be done in supraglottic surgery due to the anatomic characteristics at the anterior commissure level); 2) neoplastic infiltration of the cricoid cartilage takes place exceptionally in supraglottic and glottic neoplasms; in such cases neoplastic manifestation can be radiographically identified. Generally removal of the soft tissues and of the perichondrium within the cricoid area grants conservative surgery the same oncological radicality as that of total laryngectomy. Insights into restoration of laryngeal function when employing the arytenoid-preserving technique are as follows: 1) conservation of the recurrent nerve(s) 2) pulling the base of the tongue back and downward; close to the crico-arytenoid structure can be achieved by crico-hyoid-pexy. In the technique involving removal of the arytenoid: 1) reconstruction of two pseudo-arytenoids 2) the base of the tongue has to be brought close to the edge of the cricoid cartilage possibly by crico-hyoid-pexy. A total of 21 patients have undergone surgery with these techniques since 1984 and to date no neoplastic recurrences have been observed. Those who underwent surgery where the arytenoids were preserved (16 cases) showed laryngeal functional recovery times similar to those for supraglottic surgery. The recovery times were longer for those undergoing bilateral arytenoidectomy (5) and this was especially so for swallowing.

Adult↗