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Biomedical subjects

L Biland

Publications and source records attributed to L Biland.

At least 37 records · Page 2Linked to original sources
PubMed1978

Quantitative estimation of coagulation factors in liver disease. The diagnostic and prognostic value of factor XIII, factor V and plasminogen.

20 coagulation parameters were investigated in 144 patients with different liver diseases. The groups of acute hepatitis, chronic active hepatitis and liver cirrhosis were compared and the prognostic value of the coagulation analyses investigated. It is clear that the determination of the factor V activity is a good and easy test for detection of actual liver function. Repeated controls over several weeks revealed with a statistical significance (p less than 0.0005) that all patients with a factor XIII below 35% and a plasminogen below 19% will die in liver coma, if they have not died beforehand from acute gastrointestinal haemorrhage, acute infection or cardiac arrest. Plasminogen is also lower in the group of non-survivors but the values of the two groups are overlapping and of no prognostic help in a single case. The possible causes of the diminution of factor XIII activity are discussed.

Adolescent↗
PubMed1976

[Graft versus host disease, a little known complication of blood transfusion].

A case of fatal graft-versus-host disease (GvHD) following blood transfusions is reported. This relatively rare complication of blood and bloodcomponent replacement therapy may occur in recipients with decreased cellular immunity, which may be due to the underlying disease, chemotherapy or radiation therapy, or a combination of both. GvHD is a result of active proliferation of transfused immunologically competent cells which attack host organs. This complication can be prevented by irradiating transfusions with 1500 rads in vitro.

Adult↗
PubMed1975

[Hemophilia A: early detection of women carriers by Laurell's quantitative immunoelectrophoresis].

Using one-stage quantitative factor VIII assay and the quantitative immunoelectrophoretic method of LAURELL a good correlation has been found between factor VII activity and protein concentration. In 80% of the known hemophilia A carriers the protein concentration was about twice as high as in normals as compared to the factor VIII activity, whereas about 20% of the known carriers have the same ratio between factor VIII protein and factor VIII activity as normals. The reliability of the test and its usefulness for the detection of hemophilia A carriers are discussed.

Antibodies, Heterophile↗
PubMedDate not supplied

Doxium 500 in chronic venous insufficiency: a double-blind placebo controlled multicentre study.

The aim of this double-blind placebo-controlled study was to evaluate the therapeutic efficacy of Doxium in chronic venous insufficiency (CVI). 225 patients were treated randomly for 4 weeks with 1.5 g (3 capsules/day) of Doxium or placebo. The evolution of the leg oedema was determined by measuring calf and ankle circumferences. Pain and discomfort were assessed by visual analogue scale. The results show that at the end of the trial, all the examined parameters (leg oedema, pain, day and night cramps, discomfort, heavy legs, paresthesia and restless legs) were significantly more improved in the Doxium group than in the placebo group: the leg volume was diminished by 3.8% in the Doxium group compared to 1.2% in the placebo (p less than 0.005). The overall assessment by the physicians showed an improvement in 82% of the Doxium-treated patients compared to 42% of the placebo group (p less than 0.0001). The tolerance of the treatment was comparable in both groups.

Calcium Dobesilate↗
PubMedDate not supplied

[The course of varicose disease. Parallel retrospective study of 2 ethnic groups (Catania-Basel)].

Authors presents a retrospective study with two different ethnic groups, one of them from Catania and the other from Basilea, with varicose veins and subjected to a saphenectomy. They studies the following parameters: age at the entrance, and when varicose veins appeared; correlation between varix appearance date and subjective symptomatology; and rapport between varix complications and its duration. The possible incidence of "ambiental factor" and contrasts between the two groups are considered.

Adult↗
PubMedDate not supplied

[Varices, a true disease?].

There is little agreement on the real prevalence and significance of varices of the lower limbs. The discrepancies between the data produced by the various studies are attributable to several factors, of which the most important has to be the absence of any definition of the forms and types of varices. In the Basle study there has been an attempt to classify into two groups, "disorder" and "disease", according to the severity of the clinical picture. These two groups are clearly distinct regarding complications and the number of risk factors. A study on the long-term development has also shown that at the end of 11 years the group "disease" more frequently presented socio-medical after-effects than the group "disorder". Pronounced varices therefore do constitute a real disease and merit appropriate attention.

Female↗
PubMedDate not supplied

Incidence and course of occlusive peripheral artery disease in geriatric patients. Possibilities and limits of prevention.

The fate of patients with chronic and acute OPAD was analysed in order to delimit needs and limits of preventive measures. Chronic disease. A high 5 year incidence of OPAD and a strong correlation with the risk factors at entry was observed in 2630 men initially free of disease. The incidence was at 114% in men with 3 risk factors vs 20% in the subgroup free of risk at entry. In a 11 year follow-up study of 239 men with OPAD a high mortality of 37% was observed vs 13% in the age-matched randomized controls. Death was due to coronary heart disease (CHD) in 15.1% of OPAD vs 1.7%. The mortality was significantly correlated with the risk profile at entry 46% in persons with several risk factors vs 19% in those free of risk. The strong correlation between the risk profile and morbidity/mortality indicates that primary prevention by reduction or elimination of risk factors could successfully avoid or postpone CHD and OPAD, if started early and not only at the threshold of the 3d life. Acute disease. The analysis of a geriatric subgroup, 141 patients older than 70 years, demonstrated that acute artery occlusion is a limb-and life-threatening event with an in-hospital mortality of 33% and an amputation-rate of 19%. Life together with limb salvage was obtained, in spite of thrombectomy thrombolysis or anti-coagulants, in only 57%. The subgroup at increased risk could have been recognised in advance by antecedent atrial fibrillation, OPAD and/or myocardial infarction; 50% presented indeed with several, 33% with one and only 17% without the mentioned conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗