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Biomedical subjects

L Boccon-Gibod

Publications and source records attributed to L Boccon-Gibod.

At least 217 records · Page 12Linked to original sources
PubMed1989

Systemic bacillus Calmette-Guerin infection in patients treated by intravesical BCG therapy for superficial bladder cancer.

Among 169 patients treated for superficial bladder tumors with intravesical instillations of 150 mg BCG-Pasteur, five developed BCG-itis--a severe systemic infection with bronchopulmonary lesions and granulomatous hepatitis. In four cases, the complication appeared early during treatment (after three, six, six and eight instillations respectively). In one case, BCG-itis appeared 6 months after completion of 2 years monthly maintenance therapy. In addition to pulmonary basal infiltration and granulomatous hepatitis, intramedullary granulomatosis was observed. In three patients, the role of trauma has to be considered, as BCG-itis appeared after a traumatic instillation with bleeding. All patients were cured by combined treatment with Rifampicin, Isoniazid and Prednisolone.

Administration, Intravesical↗
PubMed1989

[Infiltrating tumors of the bladder. Local response to systemic platinum-based chemotherapy].

16 patients with invasive bladder cancer were treated primarily "bladder in place", with chemotherapy. (M-VAC, CDDP + MTX). There were 11 with T1 to T4, N+, M0, M+, 5 with T1, T2, N0, M0. The aim of the study was to evaluate the response of bladder lesions to chemotherapy. 2 had complete response (CR), 6 partial response (PR) and 8 no-response (NR). Patients with complete responses and partial responses were found to have complete resection before chemotherapy. Unresectable lesions were associated with NR patients. The results did not show a significant improvement and they question the role of neo-adjuvant chemotherapy.

Aged↗
PubMed1989

[Detection of a prostatic adenocarcinoma in the cysto-prostatectomy specimens of an invasive tumor of the bladder].

Among one hundred consecutive patients submitted to radical cysto-prostatectomy for invasive transitional cell carcinoma of the bladder, 26 also exhibited adenocarcinoma of the prostate on histological specimens: 17 microscopic foci and 9 larger prostate carcinomas. In 3 cases, the tumor was found in the apex of the prostate gland. Pelvic lymphadenectomy was positive in 4 cases but always corresponded to a urothelial metastasis. Follow-up was never marked by a metastatic development of this adenocarcinoma. This frequency of latent prostatic adenocarcinoma is not different from its observed incidence in the general population on autopsy studies. The high incidence of this association makes removal of the whole prostatic tissue during total cystectomy necessary.

Adenocarcinoma↗
PubMed1989

[Early endoscopic treatment of a complete traumatic rupture of the membranous urethra].

A man presenting complete traumatic disruption of the membranous urethra, with a 1 cm gap between the proximal and distal urethra, underwent successful endoscopic reconstruction ten days after the injury. When the urethral catheter was removed after fifteen days, peak flow rate was 25 cc per second. One internal urethrotomy was necessary 8 months later. Twenty months after the injury, cystography and retrograde urethrography revealed satisfactory restoration of urethral continuity. We suggest that this treatment be considered in complete traumatic disruption without hematoma and with less than a 1 cm gap between the proximal and distal urethra.

Cystoscopy↗
PubMed1989

[Urologic manifestations of AIDS].

The frequency of urological manifestations of AIDS appears to be increasing at the present time: between 1985 and 1988, 38 HIV1 seropositive patients were examined in the Urology department. In seven cases, the positive serology was discovered during investigation of a urogenital infection and 21 patients suffered from declared AIDS. The reasons for admission to hospital were: urogenital infection: 14 cases, dominated by epididymitis (7) and prostatitis (5), characterized by their frequent progression towards abscess formation; tumours: 6 cases, including 5 Kaposi sarcomas of the penis; and, lastly, neurological manifestations, chronic renal failure and urological diseases unrelated to AIDS. This study indicates that serology should be performed routinely in cases with a known risk factor and/or with an atypical urogenital condition, particularly infectious. The adoption of aseptic techniques and rigorous protection of the entire surgical team is now absolutely necessary.

Abscess↗
PubMed1989

Bladder tumors invading the lamina propria (stage T1): influence of endovesical BCG therapy on recurrence and progression.

We treated 47 patients with transitional cell bladder carcinoma invading the lamina propria (stage T1) from 1984 to 1986 with complete transurethral resection followed by one to three courses of endovesical BCG instillation and followed them for 14-64 months with cystoscopic and endoscopic tests and bladder biopsy. Complete response was achieved in 64%, and 36% had recurrences (recurrence rate per 100 month/patient, 2.2); 21% progressed to muscle invasion. Duration of treatment, tumor size or type (solid versus papillary), and presence of carcinoma in situ bore no relation to the final result. A history of previous T1 bladder tumor appeared associated with a higher risk of progression, although not statistically significantly. The results were compared with those obtained by transurethral resection alone in a similar group of 50 patients treated from 1982 to 1984 and followed for 12 to 100 months. Of these 90%, had recurrence, and 34% progressed to muscle invasion, with a recurrence rate per 100 month/patient of, 9.2. In light of the limits of a non-randomized historical comparison, it appears that endovesical BCG therapy favorably alters the recurrence pattern of T1 bladder cancer.

Administration, Intravesical↗
PubMed1989

[Familial pulmonary hemorrhage and lupus syndrome with C4 deficiency].

A six year old girl developed severe pulmonary hemorrhage following appendectomy. Clinical findings and results of immunfluorescence studies of skin, lung and renal biopsy specimens were consistent with systemic lupus erythematosus (SLE). A sister also had hemoptyses and a lupus syndrome. Both girls, but none of the other siblings or parents, were shown to have a partial C4 deficiency. A review of the literature disclosed 13 pediatric cases of SLE with pulmonary hemorrhages. In none of these cases was congenital C4 deficiency reported (although C4 deficiency is known to induce autoimmune diseases, including lupus). Our two patients are therefore the first reported cases of SLE with pulmonary hemorrhage and a partial congenital C4 deficiency.

Biopsy↗
PubMed1988

[Renal angiomyolipoma. Diagnostic value of magnetic resonance imaging].

Owing to the wider use of ultrasonography, renal angiomyolipoma is now diagnosed with increasing frequency. Within a few months, 10 female patients were explored by ultrasounds, computerized tomography and nuclear magnetic resonance (Magniscan 5,000, 0.5 Tesla). At ultrasonography the lesion was hyperechogenic in 9 cases and heterogenic in 1 case. At computerized tomography 7 patients had a strongly hypodense lesion and 3 had a lesion of slightly positive density. At magnetic resonance imaging the lesion produced a characteristically loud signal similar to that of fatty tissues. In practice, ultrasonography and computerized tomography combined provide the diagnosis in most cases. In case of doubt, especially since the tumour may be small and asymptomatic and the lesions multiple and/or bilateral, magnetic resonance imaging with its fat-like loud signal confirms the diagnosis and leads to partial resection. When no complications are present, it may even suggest that surgery is unnecessary.

Female↗
PubMed1988

[Prostate-specific antigen. A new marker of prostatic pathology].

Prostate-specific antigen (PSA) and prostate acid phosphatase (PAP) were assayed using a radioimmunologic method in 306 patients from November 1986 through April 1987. Study patients included 10 women, 10 men under forty years of age, 25 patients with malignancies involving structures other than the prostate, and 280 patients with diseases of the prostate ie. benign hypertrophy of the prostate (BHP) (n = 170), or histologically-proved carcinoma of the prostate (CaP) (n = 110). Serum PSA levels were undetectable in women and following total prostatectomy; levels of 3 ng/ml were found in young men, with no circadian variations. Non-prostatic carcinomas had no influence on PSA levels. PSA levels in BHP patients were 6.9 +/- 8.4 ng/ml and correlated positively with the weight of the gland. In patients with carcinoma of the prostate, PSA levels were 24.4 +/- 19.3 ng/ml, correlated positively with tumor spread, and returned to normal following successful palliative hormone treatment, with new increases reflecting recurrences. PSA assays are of little value for screening for carcinoma of the prostate; however carcinoma of the prostate is found in 70% of patients with inconsiderable BHP and PSA levels above 15 ng/ml. PSA is mainly useful for monitoring patients with carcinoma of the prostate. No patient with BHP had marked elevations of PAP, whereas high PAP levels were found in 26% of patients with carcinoma of the prostate. Eighty-eight per cent of patients with carcinoma of the prostate had increased PAS levels, which were the only finding in 48 cases. No patient with carcinoma of the prostate had increased PAP levels with normal PSA levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Acid Phosphatase↗
PubMed1988

[Solid tumors in children. New advances and the importance of histological sub-classifications. I. Renal tumors in children].

New information is now provided to the pediatric pathologist through the application of new techniques as immunocytochemistry, cytogenetics, flow cytometry, etc... Their confrontation with better analysis of histopathology and extremely valuable data provided through Electron Microscopy and tissue culture has led to important progress in sub-classification of tumors, and especially definition of histologic patterns correlating with favorable or unfavorable response to therapy. This is especially true in the field of renal tumors. Clear cell sarcoma of the kidney (CCSK) and malignant rhabdoid tumors (MRTK) have recently been isolated as tumors of unfavorable prognosis. The actuarial 2-year survival rate is 49% for CCSK and 10% for MRTK (versus 95% for Wilms' Tumor). Amongst tumors of good prognosis are congenital mesoblastic nephroma which can be considered as a benign tumor, when no atypia is present, and cystic partially differentiated nephroblastoma, which is potentially malignant but in most cases is related to favorable outcome. Attention should be now focused on minimising the sequela of treatment, which requires different strategies according to extension of disease and histologic subclassification.

Adenocarcinoma↗