Biomedical subjects

L Bolle

Publications and source records attributed to L Bolle.

3 recordsLinked to original sources

PubMed1996

Neurobehavioral test performance among apprentice painters: baseline data.

In the debate on chronic effects of solvent use, it is often difficult to find information on the cerebral health status of subjects before any exposure has occurred. The objective of this study was to obtain baseline data by examination of workers at the beginning of their occupational lives. This study compares the performance of 57 apprentice painters, mean age 16.6 +/- 1.2 years, with that of 62 apprentices, mean age 16.2 +/- years, drawn from other manual trades involving no significant exposure to solvents. Their performances were compared twice over a period of 3 years using a series of behavioral tests chosen from a translated version of the Neurobehavioral Evaluation System (NES). There were no major differences in performance between the apprentices, except for the verbal ability test, which showed lower results for painters. This can be explained by factors such as socioeconomic background, previous schooling, or mother tongue, and raises the question of whether it is appropriate to use such a test to adjust for the influence of premorbid ability in elderly exposed workers.

Adolescent↗

PubMed1992

A modified Hortega-Globus stain is superior to Bielschowsky and Bodian stains for demonstrating neuritic plaques.

The quantitative assessment of the age-dependent number of neuritic plaques is essential for the diagnosis of Alzheimer type dementia. This study reports the superiority of a modified Hortega-Globus stain compared to Bielschowsky and Bodian stains applied to samples obtained from ten brains of patients with a clinical history of progressive dementia. In two of ten cases only the modified Hortega-Globus stain allowed confirmation of the diagnosis of senile dementia of the Alzheimer type (SDAT). The counts of neuritic plaques in sections stained by other methods were not sufficient to establish the histological diagnosis of SDAT. These results indicate that the choice of the most sensitive staining method is critical for the correct histopathologic diagnosis of the Alzheimer type dementia.

Aged↗

PubMedDate not supplied

Basal metabolic rate in relation to body composition and daily energy expenditure in the field vole, Microtus agrestis.

Basal metabolic rate in the field vole (Microtus agrestis) was studied in relation to body composition and daily energy expenditure in the field. Daily energy expenditure was measured by means of doubly labelled water (D2 18O). In the same individuals, basal metabolic rate was subsequently derived from O2 consumption in an open-circuit system in the laboratory. Body composition was obtained by dissecting the animals and determining fresh, dry, and lean dry mass of different organs. Daily energy expenditure for free-living field voles ranged from 1.8 to 4.5 times basal metabolic rate, with an average of 2.9 times basal metabolic rate. Variation in both daily energy expenditure and basal metabolic rate was best explained by body mass. Gender or reproductive activity did not have significant additive effects. Daily energy expenditure and basal metabolic rate showed significant positive relationships to body mass with similar mass exponents of 0.493 and 0.526, respectively. Overall, there was a significant correlation between daily energy expenditure and basal metabolic rate, but the mass-independent residuals (deviations from the allometrically predicted values) did not correlate. Carcass analysis revealed that a number of organs were slightly better predictors for daily energy expenditure and basal metabolic rate than was fresh body mass. Mass-independent residuals of lean dry heart mass and basal metabolic rate were positively correlated, which is in agreement with the idea that basal metabolic rate reflects the size of metabolically active organs. The study does not provide support for an intraindividual association of basal metabolic rate with daily energy expenditure in the field.

Animals↗