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L Bornová

Publications and source records attributed to L Bornová.

4 recordsLinked to original sources
PubMed1993

Predicting therapeutic results with levoprotiline and maprotiline in major depression: the role of the outcome criteria.

We describe a double-blind study involving 58 in-patients with major depression (DSM-III). After one week on placebo, the patients were randomly assigned to either levoprotiline or maprotiline treatment for three weeks. In the next three weeks, responders were maintained on the same medication and non-responders were shifted to treatment with the complementary drug. After the initial three weeks' treatment, 31% of levoprotiline patients and 58% of maprotiline patients had responded. Both in the initial three-week period and after shifting non-responders to the complementary drug, there were significant differences in favour of maprotiline. The comparison of properties of different outcome criteria in prediction analyses shows that the final score gives the best agreement with global evaluation; using the delta score (final minus baseline) or ratio score (final/baseline) as the outcome criterion may yield paradoxical results.

Adult↗
PubMed1992

[Results of a clinical trial of levoprotiline].

The authors submit results of a double blind clinical trial of levoprotiline controlled by maprotiline. In the multicentre study (which is processed and interpreted in stages) participated after written informed consent 58 patients with the diagnosis of a major depressive disorder. During the first three weeks the results of levoprotiline and maprotiline (from 26 patients each) were processed. The trial lasted 42 days. The psychopathology of the patients was evaluated by independent blind raters by means of Montgomery and Asberg's scale (MADRS), Hamilton's scale for depression (HRDS) and general clinical impression (CGI). In all patients also the pharmacological and EEG response was assessed. In comparison to maprotiline, levoprotiline was clinically ineffective. Its plasma levels (40 ng/ml) were one third to one half of the values obtained with maprotiline in the same daily dosage (150 mg). Although levoprotiline has an EEG profile typical for classical thymoleptics, its clinical antidepressive action is negligible.

Adult↗
PubMed1990

[Clinical problems in postpartum psychoses].

The authors analyzed post-partum psychoses treated at the Psychiatric Clinic of the Faculty Hospital in 1985-1986. The group comprised 41 patients. Post-partum psychoses are not considered a separate nosological unit nor symptomatic mental disorders but are classified as endogenous psychoses, provoked by childbirth. As to endogenous psychoses, most frequently manic depression is involved, as suggested by the clinical picture and course. Schizophrenia is found less frequently, as compared with manic depression, the cca 1:10. In rare instances post-partum symptomatic psychosis may develop.

Adult↗