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Biomedical subjects

L Boschiero

Publications and source records attributed to L Boschiero.

9 recordsLinked to original sources

[Hyperparathyroidism in patients having undergone a kidney transplant].

The persistence or onset of hyperparathyroidism following kidney transplant is characterized by an incidence ranging from 2.6 to 70% according to the various statistics available. In a total of 462 kidney transplants performed in our department, hyperparathyroidism was detected in 9 patients. Surgery took the form of parathyroidectomy 8/8 plus autograft in 3 cases, parathyroidectomy 3/4 in 2 cases, 7/8 in 2 cases, and 4/8 in 1 case. Serum calcium values returned to normal in all patients after the operation.

Humans

[Cyclosporin A in immunosuppressive therapy of kidney transplants (clinical results in 55 patients)].

The authors report the results of a clinical study of the use of cyclosporin A plus low-dose steroids in a consecutive series of 55 kidney transplants with follow-up ranging from 6 to 20 months. The clinical results (rejects, immunosuppressant side effects, 12-month survival of transplant and patient) are compared with those of a similar group of patients on "traditional" therapy (azathioprine plus high-dose steroids). The results of the study confirm the efficacy of cyclosporin A in preventing and controlling acute reject crises in the course of allogenic transplant, though many of the problematic issues related its clinico-therapeutic management remain open questions.

Cyclosporins

[Malignant neoplastic pathology in patients given a kidney transplant].

The incidence of malignant neoplasms in patients subjected to pharmacological immunosuppression following kidney transplantation is higher than that observed in the control population at large. In our unit, in a study population of 451 patients undergoing a total of 462 kidney transplants over the period from 1968 to 1986, four malignant neoplasms (0.9%) were observed in 3/369 (0.8%) patients treated with azathioprine (1 ovarian papilliferous cystoadenoma, 1 embryonal carcinoma of the testicle and 1 Kaposi's sarcoma) and in 1/93 (1.1%) patients treated with cyclosporin (1 Kaposi's sarcoma). The neoplasm was successfully controlled only in the first case after bilateral extended adnexectomy.

Azathioprine

[Echographic monitoring of 80 renal transplants. Critical analysis of signs of graft rejection].

In a period of one year and a half, the follow-up of 80 patients after renal transplant has been monitored with echography. Altogether were made 418 echographies, which later were correlated with the clinical conditions of the patients at the moment of each echography. As rejection represents the most important complication, care was particularly given to the possibility of sonographic identification of such pathology. The sensitivity, specificity and diagnostic accuracy of each echographic sign in the diagnosis of rejection were evaluated. The absent or reduced renal sinus (sensitivity 63%) and hyperechogenicity of the cortical parenchyma (sensitivity 50%) resulted the most important signs in the diagnosis of rejection, while the increase of renal volume and the increased hypoechogenic pyramids resulted less reliable. The combination of three or more signs proved to be particularly significant.

Adolescent

[Adenoma nephrogenic. Morphologic aspects].

Nephrogenic adenoma is a rare lesion of urothelial mucous membrane. At present, the cases described in literature are 85. In this work the Authors study the morphologic aspects and etiopathogenetic theories.

Adenoma

[Renal-colonic-cutaneous fistula secondary to xanthogranulomatous pyelonephritis].

The appearance of intestinal fistulas secondary to kidney disease is a rare occurrence. Even rarer are complex fistulas involving several organs or systems [correction of apparati]. In this study, the authors report on a case of reno-colo-cutaneous fistula which set in as a complication of xanthogranulomatous pyelonephritis.

Colonic Diseases

[10 cases of xanthogranulomatous pyelonephritis].

Xanthogranulomatous pyelonephritis (XGP) is a chronic inflammation of the kidney usually associated with renal stones, recurrent urinary tract infections or endocrine disorders. A correct preoperative diagnosis is rarely made, since no specific clinical or radiological pattern is known. Differential diagnosis must include renal tuberculosis and renal carcinoma. Ten cases of XGP are reported. Clinical findings, radiological and pathological features, biolaboratory abnormalities are discussed.

Adult