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Biomedical subjects

L Botta

Publications and source records attributed to L Botta.

49 records · Page 3Linked to original sources
PubMed1984

[Effect of various vasoactive drugs on synaptic transmission in the orthosympathetic ganglia in man].

The effects of the following vasoactive drugs: Bencyclan fumarate, Cetiedil citrate, Cinepazide maleate, Dihydroergocristine methane sulphonate, Nafthydrofuril acid oxalate, Papaverine hydrochloride, Piribedil monomethane sulphonate, Raubasine, Thymoxamine hydrochloride and Xanthinol nicotinate, in concentrations ranging between 0.001 - 2 mM, were tested on the compound action potentials led off from human isolated sympathetic ganglions. The experiments, carried out on 50 isolated lumbar ganglion preparations removed from 23 subjects with arteriopathy of the limbs, indicated that all the drugs are able to impair the synaptic transmission, although at different concentrations. These findings are in favour of the hypothesis that the vasodilatatory effects observed after therapeutic treatment of patients with vasoactive drugs are partially produced by the vasodilatation following the depression of the sympathetic nervous transmission.

Action Potentials↗
PubMed1983

[Effects of temperature on postsynaptic potentials at the cyto-neural junctions of the frog semicircular canal].

An analysis of the EPSPs recorded intracellularly from single fibres of the VIII nerve revealed that the resting release of chemical transmitter at the cyto-neural junctions in the sensory organ of frog semicircular canals displays a rather low temperature dependence. This provides evidence that, in labyrinthine receptors, the resting activity is actually "evoked" in nature. A comparison between the discharge of EPSPs and propagated spikes in the VIII nerve fibres has shown that the "encoders" of primary vestibular neurones are highly sensitive to temperature changes and irreversibly damaged at temperatures exceeding 28 degrees C.

Animals↗
PubMed1983

[Temperature dependence of electrical potentials in the frog semicircular canal].

The temperature dependence of conversion processes in the sensory organ of frog semicircular canals has been tested in the range 0-28 degrees C by recording the ampullar (Adc) and nerve (Ndc) slow potentials as well as the afferent discharge of impulses (Nfr) in the VIII nerve fibres. The results have shown that Adc is scarcely affected by temperature changes (Q10 less than 2) thus suggesting that stimulus conversion in labyrinthine cells does not imply chemical processes but mainly potassium conductance changes at their apical membrane. By converse, postsynaptic potentials and propagated spikes are markedly reduced at low temperatures (Q10 2.8 and 7 respectively) and only slightly increased between 20 and 28 degrees C. These observations are interpreted by considering the chemical nature of the processes which are involved. The temperature dependence in labyrinthine receptor activation is discussed in the view of its physiological meaning.

Animals↗
PubMed1981

[Value of the use of tissue adhesive (Braun Histoacryl) and its importance as a safety measure in difficult anastomoses].

In an experimental and then clinical investigation, the intention has been to demonstrate that tissue adhesive (Histoacryl Braun) is a useful safety factor in a wide variety of difficult intestinal sutures, in both emergency surgery and in that of choice. Experiments were carried out on about a hundred rabbits which received colic anastomosis, after clean, complete section, anastomosis of the viscera, with four cardinal sutures in 000 silk and the remaining suture of a diameter of about 3 cm with adhesive. This stage having been surmounted with excellent results, work continued with the experiment in emergency surgery and surgery of choice, on the basis of the criterion of greater safety as a complement of the traditional high dehiscence risk suture technique. The clinical results obtained thus far have been encouraging enough to suggest its experiments.

Aged↗
PubMedDate not supplied

[Surgical treatment of perforated diverticulitis of the colon].

An appraisal is made of the methods adopted by surgeons from different schools in the surgical management of perforated diverticulitis of the colon. For this purpose, an examination is made of 27 cases treated over the course of 5 years at the First-Aid Section of the Genoa General Hospital. While approval is expressed of an eclectic approach to individual cases in the light of the patient's condition, it is felt that the long-established tactic of exteriorisation and resection according to Mikulicz is still perfectly sound.

Adult↗