Biomedical subjects

L Boudová

Publications and source records attributed to L Boudová.

At least 37 records · Page 2Linked to original sources

PubMed2001

[Carcinoid of the ileocecal junction with symptoms of acute abdomen].

The authors describe a group of six patients (two men and four women) operated at the Surgical Clinic in Plzen during 1995-2000 on account of a carcinoid of the GIT. The mean age of the patients was 48.6 years, the range 14-77 years. In five instances a carcinoid of the appendix was detected. In a separate case-record they evaluate a carcinoid of the ileocaecal transition with symptoms of acute abdomen, early surgery, its extent incl. the postoperative procedure.

Abdomen, Acute↗

PubMed2001

Chlorpromazine-induced cholestatic liver disease with ductopenia.

We describe a 30-year-old pregnant woman in whom cholestatic liver disease developed 16 resp. 18 days after the medication of chlorprothixeni hydrochloridum and chlorpromazine treatment in the 33rd week of pregnancy. Clinically, the course was characterized by severe jaundice lasting 10 months, fever, pruritus, high serum alkaline phosphatase level, transient aminotransferase elevation, and hypercholesterolemia. The pregnancy was terminated in the 35th week by cesarean section with the birth of a premature female newborn without any signs of liver damage. The histological examination of the mother's liver revealed ductopenia, defined by the absence of interlobular bile ducts in at least 50% of the small portal tracts, and long-standing cholestasis with pseudoxanthomatous transformation of hepatocytes and ductular epithelia, and small lobular xanthomas. The jaundice resolved very slowly after ursodeoxycholic acid therapy. The liver function tests 26 months after the onset of jaundice showed only a slight elevation of alkaline phosphatase and aminotransferases. In the control liver biopsy, non-active periportal and septal fibrosis without signs of cholestasis was seen. To our knowledge this is the sixth report to document chlorpromazine-induced ductopenia in pregnancy and the first to describe a newborn without any liver damage.

Adult↗

PubMed2001

[Sclerosing epithelioid fibrosarcoma].

Sclerosing epithelioid fibrosarcoma (SEF) was first described in 1995 and since then 39 cases have been reported. Here we describe 6 cases of SEF (3 in women and 3 in men). The patients aged from 22 to 79 years. The tumours were located in soft tissues of the extremities (in 3 cases in the lower, in 2 instances in the upper extremity) and of the trunk (in 1 case). The lesions were partially nodular, of gray-white colour, and hard in consistency. Histologically, they were composed of epithelioid round to ovoid small cells with a sparse cytoplasm and a very low mitotic activity. The tumour cells formed cords and alveoli or were scattered individually within a dense hyalinized collagenous stroma. The neoplasms also contained foci of conventional fibrosarcoma, necrosis, calcification, and metaplastic bone. On immunohistochemistry, the neoplastic cells were positive for vimentin. Two cases were immunoreactive for epithelial membrane antigen and one tumour also for cytokeratins. The proliferative activity, assessed by MIB 1 antibody (Ki-67), was detected in 1-6% of neoplastic cells in primary tumours. Follow-up information was available in 5 patients. In two cases, there were local recurrences and distant metastases (in the lungs, upper extremity, and mediastinum). One of these patients died of SEF. The differential diagnosis of this relatively low-grade fibrosarcoma is broad and includes, along with a variety of benign and malignant soft tissue lesions, infiltrating carcinoma, and, to a lesser extent, sclerosing lymphoma.

Adult↗

PubMed2000

[Effect of physical activity on serum leptin levels].

Leptin is a protein hormone produced predominantly by adipocytes. Its serum concentrations usually reflect the total body fat content i.e. they are higher in obese than in lean subjects. The aim of our study was to follow the influence of the regular hard physical training on the serum leptin levels. Therefore, the serum leptin levels in top rugby players, top race walkers and age and gender-matched control group were compared. The relationship between serum leptin concentrations and body mass index and body fat content was also studied. It was found that serum leptin levels in rugby players were significantly higher than in race walkers group, but lower than in control one. Serum leptin levels in race walkers were lower than those of rugby players and of control group. The body fat content in race walkers was lower than in resting two groups. There was no significant difference in body fat content between control and rugby players group. Serum leptin levels correlated positively with body mass index and body fat content both in control and in rugby players group. No statistically significant relationship was found between leptin and body mass index or body fat content respectively in race walkers group. We conclude that serum leptin levels in top sportsmen are lower than in non-sporting healthy age and gender-matched controls. The lower leptin levels in top sportsmen are probably in part the result of lower body fat content and in part the result of complex neurohormonal adaptation on the long term physical training.

Adipose Tissue↗

PubMed2000

[Intestinal T-cell lymphoma].

In our study, 7 bioptical specimens of intestinal T-cell lymphoma are described. This tumour occurs in the small intestine of adults who may have a history of malabsorption. The patients present clinically with intestinal perforation, enterorrhagia, or ileus. The gross appearance varies: the tumour may take the form of multiple ulcers or of a huge exulcerated lesion. The cytomorphological features are variable. Bizarre multinucleated cells may be sometimes present. The reactive cellular background is usually dominated by histiocytes or eosinophilic granulocytes. Immunohistochemically, the tumour cells stain in reactions with antibodies to pan T-cell markers, occasionally to CD8 and CD30. The positivity of tumour cells for markers of intraepithelial T-cells and for cytotoxic molecules has been demonstrated previously.

Adult↗

PubMed1999

Atypical decubital fibroplasia associated with bizarre parosteal osteochondromatous proliferation (Nora's reaction).

We describe recurring bizarre parosteal osteochondromatous proliferation (Nora's reaction) associated with atypical decubital fibroplasia in the region of the greater trochanter of the femur in a 52-year-old man. We hypothesize that these two recently introduced entities may represent two forms of tissue response to injury (ischemia) inducing proliferative reaction of bone and cartilage in the vicinity of periosteum, and necroses with hyperplastic granulation tissue and myxoid stroma in the subcutaneous tissues.

Bone Neoplasms↗

PubMed1999

[Effect of aerobic training in top athletes on serum leptin: comparison with healthy non-athletes].

Leptin is a protein hormone produced by adipocytes. Its serum concentration in the most of cases precisely reflect the total body fat content. The aim of our study was to follow up the influence of regular aerobic training on serum leptin levels. Therefore the serum leptin levels, basic anthropometric parameters and serum lipids were compared in 11 intensively trained race walkers and 10 age-matched non sporting control subjects. We have found, that serum levels, body weight, body mass index, body fat content, total and LDL-cholesterol were significantly decreased in walkers group in comparison with control subjects. Serum leptin levels positively correlated with body fat content and body mass index only in control group, in the walkers group the correlation was non-significant. The results of our study demonstrate, that regular aerobic training accompanied with the decrease of body fat content leads to the significant drop of serum leptin levels.

Adipose Tissue↗

PubMed1998

Lower serum leptin concentrations in rugby players in comparison with healthy non-sporting subjects--relationships to anthropometric and biochemical parameters.

Leptin is a protein hormone synthesized by adipocytes. Its serum concentrations reflect the total body fat content. Serum leptin concentrations are significantly higher in obese than in lean people and in women than in men. However little information about the influence of physical activity on serum leptin concentrations is available. We have compared the body weight, the body mass index (BMI), the body fat content (measured by caliper as skinfold thickness) and the serum concentrations of leptin, triglycerides, total, high density and low density lipoprotein (LDL) cholesterol in 14 top rugby players and 10 healthy controls. We found that serum leptin, total and LDL cholesterol concentrations were significantly lower in the rugby players group than in the control subjects. The body weight and BMI were significantly higher in the rugby players, while the body fat content was only slightly (non-significantly) higher in the control group. The serum leptin concentrations in both groups positively correlated with the BMI and body fat content and also with LDL concentrations in the control group. The serum leptin concentrations in the rugby players were lower than in the non-sporting subjects despite a similar body fat content in both groups. We would therefore suggest the possibility that regular hard physical training decreases serum leptin concentrations not only by the decrease of total body fat content, but also by a separate mechanism, which is not directly dependent on the changes in the amount of body adipose tissue.

Adipose Tissue↗

PubMed1998

[Risk factors for ischemic heart disease in patients with chronic fatigue syndrome].

Risk factors of coronary artery disease (CAD) between a group of patients suffering of chronic fatigue syndrome (CFS) and a control group of healthy persons (whose exercise activity was not health-limited) were compared. Thirty three patients (27 women, 6 men, average age 39.9 +/- 11.7 years) and the same number of controls matched in age (39.8 +/- 10.3 years), gender and body weight. The Minnesota Questionnaire (by Taylor) and the Compendium of Physical Activities (by Ainsworth) were used to estimate total energetic expenditure in exercise activity as well as in job. The risk factors of CAD in the patients with CFS were not higher than in the control group. Aerobic physical fitness, basic anthropometric data, blood pressure, spectrum of blood lipoproteins, blood uric acid and smoking habits were not different between the compared groups. Patients suffering from CFS had lower total energetic expenditure in exercise activity. Nevertheless, this significant difference in sports activity was not large enough to cause any difference in risk factors of CAD between the CFS patients and the control group.

Adult↗

PubMed1997

[Trends in physical fitness in male white collar workers in the Czech population over the past 20 years].

BACKGROUND: Common mortality and especially mortality on CAD is increased by low aerobic component of physical fitness. A study dealing with physical fitness changes of the Czech population has been still missing in our bibliography. The aim of the study was to evaluate physical fitness changes in the Czech male population since last 20 years. METHODS AND RESULTS: Physical fitness in 494 men in the age range of 20 - 60 years was compared to the men fitness examined 20 years ago. In the men of 20 - 29.9 years peak power (3.90 W vs 3.46 W, p < 0.01) and maximal ventilation (1.38 l.min-1 vs 1.24 l.min-1, p < 0.05) decreased. In the men 30 - 39.9 years old only peak aerobic power (37.2 ml.min-1 vs 35.7 ml.min-1, p < 0.05) slightly decreased. In the men 40 - 49.9 years old Vemax.kg-1 (1.38 l.min-1 vs 1.18 l.min-1, p < 0.001) and VO2max.kg-1 (35.6 ml.min-1 vs 32.4 ml.min-1, p < 0.001) severely decreased as well as in 50 - 59.9 years old men VEmax.kg-1 (1.23 l.min-1 vs 1.13 l.min-1, p < 0.05) and VO2max.kg-1 (32.7 ml.min-1 vs 29.4 ml.min-1, p < 0.001). CONCLUSIONS: Physical fitness of the Czech white-collar men decreased. The decline of physical fitness was related not only to lower exercise activity, but also to significant increment of body fat. Physical fitness, especially its aerobic component, decreased in Czech older men since last 20 years.

Adult↗

PubMed1995

[The effect of physical stress on rheological properties of blood].

The influence of physical load on blood viscosity was observed in the presented study. Three groups of persons were examined: 23 volleyball and football players, 96 employees of a nuclear power plant, and 49 employees of a coal power plant. The values of blood viscosity and hematocrit were determined in the quiescent state before the load, after the performance of 2W.kg-1, and after the maximum performance obtained at a bicycle ergometer. After the data processing the following results were obtained: The average performance of the trained persons was 40% higher compared to the untrained persons (power plants employees). Blood viscosity was lower before the load in the trained persons, and remained on average by 5% lower also after the maximum load. The total relative increase of the value of blood viscosity caused by the maximum load was however approximately the same in all groups (about 15%). The mean value of blood pressure increased with the increased blood viscosity, and therefore also with the increased physical load. The study contains also mathematical expressions of the observed relations.

Adult↗

PubMed1994

Physical fitness and CHD risk factors in operators and managers of nuclear and thermal power plants situated in environmentally different regions of the Czech Republic.

Nuclear and thermal power plants are seen as one of the threats to human health. Most investigations explore the potential hazards of radiation and the potential impact of a polluted environment. Less attention is being paid to the human factor, i.e. to the people who actually are directly involved in the generation of electrical power and whose sudden collapse could result in a disaster. In this paper dealing with the prevention of CHD we submit, in a condensed form, the results of our long-term testing of operators and managers from one nuclear and two thermal power plants, located in totally dissimilar regions of the Czech Republic. In our investigations, which are still going on, we are using a whole battery of methods--case history, anthropological, clinical and functional tests. Our test subjects are middle-aged men, an age group most prone to CHD. The most favourable results of the vast majority of tests were obtained at the nuclear power plant in southern Moravia, while the most adverse ones--with respect to the danger of CHD--in the men from the thermal power plant in Prague. For the most part these results, in the light of a thorough analysis of the case history, anthropological, clinical, functional and biochemical investigations of these middle-aged men, should be seen as the cumulative effect of both their way of life (locomotor activities, nutrition) and the environment, in which they live. The men working at the nuclear power plant live in the least polluted environment. People's way of life may to some extent be influenced and some preventive steps along these lines have already been taken.

Adult↗

PubMed1994

Medical and anthropological study of a world and Olympic champion, long-distance runner, 35 years after the end his racing career.

E.Z. former world champion and holder of several gold and silver medals from Olympic Games as long-distance runner, underwent at the age of 71 comprehensive investigations. In 1993 following methods were used to establish E.Z. body build and health: Family, personal and sports history, anthropometry, somatotype, body composition posture values, sports medicine examination, ECG at rest, X-rays of the lung and heart, echocardiography at rest, systolic time intervals at rest, spirography at rest, hematology, biochemistry, X-rays of bones, exercise ECG changes and spiroergometry. Today, a typical feature of E.Z.'s bodybuild is a great amount of body fats, flabby musculature, faulty posture, restricted mobility of the spinal column and surprisingly good foot arches. The clinical findings are appropriate for his age, on his ECG at rest are signs of subendocardial ischemia above the left ventricle, atrial fibrillation and ventricular extrasystoles (Lown 1 a-b). Exercise ECG resulted in a deepening of the ischaemic changes already at a working load of 50 W. Hematology revealed normochromic macrocyt anaemia, biochemistry a borderline mineralogram, hyperuricaemia, higher S-GMT and HDL-C, T-C at the limit of normal values. X-rays of the bones were remarkable in two findings of that age. The pelvis, lumbar spine and knee joints were free of the usual pathological findings (osteoarthrosis), but presented with an exceptionally advanced osteoporosis.

Aged↗

PubMed1983