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Biomedical subjects

L Bouffard

Publications and source records attributed to L Bouffard.

12 recordsLinked to original sources
PubMed2002

Insulin resistance affects the regulation of lipoprotein lipase in the postprandial period and in an adipose tissue-specific manner.

AIMS: Insulin is a potent stimulator of adipose tissue lipoprotein lipase (LPL). Logically, the postprandial period is therefore a privileged time of the day for the regulation of LPL by insulin in this tissue. It is not clear to what extent a defect such as insulin resistance could affect this regulation and contribute to postprandial, as well as fasting, hypertriglyceridaemia. The aim of the present protocol was to study the relationship between insulin resistance and LPL in adipose tissue and in plasma, in the particular context of the postprandial period. METHODS: For this study, 26 adult nondiabetic individuals (12 women and 14 men) with a wide range of whole-body insulin-mediated glucose uptake (as assessed with an insulin suppression test) were studied. An abdominal subcutaneous fat biopsy on one occasion, and post-heparin plasma on another occasion, were obtained 4 h into a standardized meal profile administered in the fasting state. RESULTS: Postprandial triglyceride excursions (evaluated by the incremental area under the curve during the metabolic meal profile) were inversely correlated to adipose tissue LPL mRNA levels (rho = -0.43, P < 0.03) as well as to adipose tissue LPL heparin-releasable activity (rho = -0.58, P < 0.01). Steady-state plasma glucose (SSPG) concentrations during the insulin suppression test, a reflection of the degree of insulin resistance, were also negatively correlated to adipose tissue LPL mRNA (rho = -0.50, P < 0.02) and activity (rho = -0.56, P < 0.01). There was no correlation between plasma post-heparin LPL activity/mass and postprandial triglycerides nor with insulin resistance. CONCLUSION: Regulation of adipose tissue LPL is significantly affected in insulin-resistant individuals in the postprandial period. This presumed impaired effect of insulin on LPL postprandially could be an important contributor to the atherogenic dyslipidaemia described in insulin resistance syndrome.

Adipose Tissue↗
PubMed1997

Personal goals and subjective well-being in later life.

With a sentence completion technique, 708 elderly participants (65 to 90 years of age) expressed 15,027 personal aspirations. These goals were classified according to their motivational content in ten major categories and their relationships with various aspects of subjective well-being were studied. Two goal profiles emerged from this analysis. Aspirations centered on self-preservation were associated with poor self-rated physical health, being burden by difficulties, lack of meaning to life, dissatisfaction with life, and negative expectations for the future. Aspirations of self-development and interest in the well-being of others were associated with feelings of well-being in later life. Development of meaningful personal goals was discussed as as a new intervention approach with the elders.

Aged↗
PubMed1992

[Future perspectives, factors in the mental health of aged persons].

During individual interviews, 708 people between the ages of 65 and 90 expressed a wide variety of personal goals and aspirations through sentences they were asked to complete. The distribution of answers in temporal categories provides an index of the broadening of future perspectives (PF). The values of that index were put in relation with subjective assessments that can be looked upon as clues to mental health. Results confirm the hypothesis of a positive relation between PF and perception of health (0.27), meaning of life (0.29), living satisfaction (0.30) and perception of having personal control (0.18). However, PF does not appear to be connected with the person's attitude toward death. These results seem to indicate that PF represents a factor of mental health and "healthy aging". Consequently, they justify the relevance of developing interventions that aim to strengthen this "personal resource".

Aged↗
PubMed1991

Sodium-phosphate cotransport and vascular reactivity.

Inorganic phosphate (PO4) alters vascular reactivity in vivo as well as in vitro. In the latter condition, low PO4 reduces, while high PO4 augments reactivity. We used phosphonoformate (PFA), a phosphaturic compound, binding the renal Na-PO4 co-transporter, to examine the existence of such a transport mechanism in selected vascular smooth muscles (VSM). Strips of aorta (A), mesenteric artery (MA), and vein (MV) were obtained from normal rabbits. All tissues were either superfused in normal PO4 (Group 1: 3 mg/dL), then in modified low PO4 (Group 2: 0 mg/dL) or high PO4 (Group 3: 9 mg/dL) Ringer's solutions. The effect of angiotensin II (AII: 10-11 to 10-8M) was tested on each tissue preparation, and contraction values obtained in the presence of PFA (18.5 micrograms/ml:0.018 ml/min) were compared to control responses in the absence of the drug. In Group 1, the contractions of A were reduced by 23% during PFA, for higher doses of AII only, compared to controls (p less than 0.01). Similarly, the contractions of MA in the presence of PFA were reduced at higher doses of AII, by 22% (p less than 0.01). Finally, the contractions of MV were reduced by 75% (p less than 0.01) for all doses of AII. In Group 2, there was no difference in vascular tissue contraction between controls and PFA, whereas in Group 3, the reduction in A, MA, and MV contractions in PFA-treated tissues were approximately twice as extensive as in Group 1 (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Angiotensin II↗
PubMedDate not supplied

Motivational goal objects in later life.

With a sentence completion technique, 708 elderly participants (64 to 90 years of age) expressed 15,020 personal aspirations. These goals were classified according to their motivational content in ten major categories and their relationships with different sociodemographic variables were studied. Two goal profiles emerge from this analysis. Aspirations centered on self-preservation are associated with very old age, functional impairment, lower S.E.S. and education, being alone or institutionalized. Aspirations of self-development and interpersonal relationships are associated with younger age, physical autonomy, higher S.E.S. and education, being married or living at home. Development of meaningful personal goals are discussed as a mean of intervention with elderly individuals.

Aged↗