Biomedical subjects

L Bridge

Publications and source records attributed to L Bridge.

3 recordsLinked to original sources

PubMed1992

The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids.

Incubation of vascular endothelial cells with S.typhosa endotoxin and interferon-gamma caused a time- and concentration-dependent reduction in the viability of the cells. The cytotoxic effect was inhibited in a concentration-dependent manner by NG-monomethyl-L-arginine, an inhibitor of nitric oxide (NO) synthesis, and by the glucocorticoids dexamethasone and hydrocortisone, two inhibitors of the induction of NO synthase. These findings indicate that in these cells the cytotoxic effect of endotoxin is mediated by the NO synthesized by an inducible NO synthase. This induction of NO synthase in vascular endothelial cells may represent a mechanism of local endothelial damage during endotoxin shock and other immunologically based conditions.

Animals↗

PubMed1986

Social support, self-esteem and depression.

A prospective study of 400 largely working-class women with children living at home has used measures of self-esteem and 'social support' to predict the risk of depression in the following year once a stressor had occurred. Actual support received at the time of any crisis in the follow-up year was also measured. Self-esteem was correlated quite highly with some of the measures of support. A core tie was defined as a husband, lover or someone named as very close at first contact. Negative evaluation of self (i.e. low self-esteem), and various indices of lack of support from a core tie at the first interview, were associated with a greatly increased risk of subsequent depression once a stressor occurred. Lack of support from a core tie at the time of the crisis was particularly highly associated with an increased risk. There was also a high risk among those who were 'let down' - that is, for those who did not receive the support which they might have expected in terms of the first interview material. It is concluded that it is essential for prospective enquiries to take account of the actual mobilization of support in the follow-up period.

Adaptation, Psychological↗

PubMedDate not supplied

Life stress, chronic subclinical symptoms and vulnerability to clinical depression.

Prospective enquiries of the role of social factors in the aetiology of depression are faced with the problem of who to exclude from the enquiry in terms of psychiatric symptomatology present at first contact. With this problem in mind the role of subclinical symptoms among women not cases of depression has been examined in terms of their relation with a subsequent onset of caseness depression. Psychosocial factors of particular importance in the development of such depression were low self-esteem, marked long-term difficulties and severe life events arising out of (or 'matching') these difficulties. These psychosocial factors were also correlated with the presence of subclinical symptoms. It is concluded that although subclinical symptoms relate to a raised risk of subsequent depression at a caseness level there is no evidence that there is inherent vulnerability stemming from such subclinical symptoms over and above that explained by the psychosocial correlates.

Adjustment Disorders↗