[Ofloxacin and metronidazole in short-term prophylaxis of septic complications after hepatocholedochal surgery].
The authors submit an analysis of septic complications after 109 operations on the hepatocholedochus. 24 patients were given before operation 400 mg ofloxacine by the oral route (Tarivid Hoechst tabl.) and metronidazole - 1 g - in rectal suppositories. None of the patients in this group died and there was no septic complication. From the control group of 85 patients 3 died and 24 had septic complications (28.2%, P = 0.001). Half the patients in the control group had metronidazole before the operation, the second half had no prophylaxis. The number of septic complications was the same in both sub-groups, however, without metronidazole seven patients had intraabdominal complications, while after its administration only abscesses in the surgical wound were encountered. The assessed ofloxacine serum and bile levels were in all instances higher than the MIC for common aerobic biliary pathogens. Ofloxacine proved useful in the prophylaxis of septic complications in surgery of the hepatocholedochus, the combination with metronidazole is an advantage as it extends the effectiveness of prophylaxis also to the anaerobic flora.