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Biomedical subjects

L Burman

Publications and source records attributed to L Burman.

7 recordsLinked to original sources
PubMed1984

Acyclovir versus vidarabine in herpes simplex encephalitis. Randomised multicentre study in consecutive Swedish patients.

127 patients with suspected herpes simplex encephalitis (HSE) were entered in a prospective randomised study of acyclovir 10 mg/kg 8-hourly versus vidarabine 15 mg/kg daily for 10 days. The patients were consecutive and nearly all Swedish cases of HSE were included; they were treated in six university infectious diseases departments. The diagnosis of HSE was verified by brain biopsy and/or antibody responses in serum and cerebrospinal fluid. Of 53 confirmed cases of HSE (corresponding to 2 X 3 cases per million inhabitants per year in Sweden), 51 (27 acyclovir, 24 vidarabine) were evaluable for analysis of efficacy. The mortality was 19% in the acyclovir-treated group versus 50% in the vidarabine group (p = 0.04). At 6 months of observation 15 (56%) of 27 acyclovir-treated patients had returned to normal life compared with 3 (13%) of 24 vidarabine-treated patients (p = 0.002); and the numbers who died or had severe sequelae were 9 (33%) and 19 (76%), respectively (p = 0.005). No important or new adverse events were recognised.

Acyclovir↗
PubMed1983

Serotyping of Streptococcus pneumoniae strains by coagglutination and counterimmunoelectrophoresis.

A total of 217 Streptococcus pneumoniae strains were serotyped by coagglutination (COA) and counterimmunoelectrophoresis (CIE). With all strains tested, there was full agreement between results obtained by COA and CIE, except for strains belonging to serotypes 7, 14, 33, and 37, which could not be typed by CIE. These strains were serotyped by passive immunodiffusion, results of which were in full agreement with those obtained by COA. Besides having the advantage of identifying strains belonging to all serotypes, COA was also more rapid and economical than CIE.

Agglutination Tests↗
PubMed1976

Autolysis of Neisseria gonorrhoeae. Relation between mechanical stability and viability.

The relationship between the mechanical stability and the viability of N. gonorrhoeae (Type 4) in suspension was investigated. A correlation between viability and optical density recordings was often found. However, in spite of increased mechanical stability in solutions with low pH (5-2) or containing Cu++ or sucrose (10 per cent.), these environments were toxic to the gonococci. A viability preserving effect by Mg++ (4 mM), Ca++ (4 mM), spermine (0-5 mM), polyvinylpyrrolidone (10 per cent.), and low temperature (4 degrees C) was demonstrated. The possibility of improving transport media for gonococci is discussed.

Bacteriolysis↗