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Biomedical subjects

L Buscarini

Publications and source records attributed to L Buscarini.

107 records · Page 6Linked to original sources
PubMedDate not supplied

Therapy of HCC-radiofrequency ablation.

Radiofrequency interstitial hyperthermia has been used for percutaneous ablation of hepatocellular carcinoma, under ultrasound guidance in local anesthesia. Conventional needle electrodes require a mean number of 3 sessions to treat tumors of diameter < or = 3 cm. Tumors up to 3.5 cm in diameter can be treated in 1 or 2 sessions by expandable needle electrodes. With both methods in all treated cases, ablation of tumors was obtained. In a group of patients with long follow-up, survival rate at 5 years was 40%. In a mean follow-up of 23 months 41% of patients had recurrences (local recurrences in 5%; new lesions in 36%), which often could be retreated by a new course of radiofrequency application. In recent experience large hepatocellular carcinomas (up to 6.8 cm in diameter) were treated by a combination of segmental transcatheter arterial embolization followed by radiofrequency application. In this way most tumors were ablated in one session of radiofrequency therapy. No fatal complications were observed. Major complications were: strong pain due to capsular necrosis in one patient; hemotorax in one case; a fluid collection in the site of ablated tumor in one patient treated by combination of transcatheter arterial embolization and radiofrequency application.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Ultrasound and ultrasonically guided biopsy in oncohematology.

Ultrasound, because of its simplicity, safety and accuracy, is considered an important and useful imaging method in the management of patients with hematological malignancies. It is able to evaluate superficial and deep tissues and organs, and to detect their neoplastic involvement or related diseases. It can easily guide percutaneous procedures such as biopsy, thoracentesis, abscess drainage, catheterization of subclavian vein, etc. Percutaneous guided biopsy is very useful in hematological patients, especially those with malignant lymphomas. This technique can provide sufficient tissue to allow histological typing and immunological subclassification. This technique can avoid traditional major procedures such as laparoscopy or exploratory laparotomy. However, ultrasound and ultrasonically guided procedures must be used in conjunction with other imaging techniques such as lymphography, computed tomography and magnetic resonance imaging.

Adrenal Glands↗
PubMedDate not supplied

Value of rapid staining and assessment of ultrasound-guided fine needle aspiration biopsies.

In a series of 160 ultrasonically guided fine needle aspiration (FNA) biopsies, immediate cytologic evaluation of each specimen's adequacy was performed using a rapid staining method. The number of passes was thus limited to what was strictly necessary in order to obtain sufficient material; the average number of passes was only 1.27 per patient. The total series of FNA biopsies had a sensitivity of 95.6%, a specificity of 100% and an overall accuracy of 97.3%. In addition, the cumulative accuracy after each pass was calculated. A significant increase in diagnostic accuracy was found only after the second pass; the third and the fourth passes gave little further improvement. The results indicate that a rapid evaluation of the aspirated material during ultrasound-guided FNA biopsy can reduce the number of punctures needed per case, resulting in less discomfort and, probably, a reduced likelihood of complications for the patient. The results also suggest that a maximum of two punctures will probably yield adequate diagnostic material in most cases.

Biopsy, Needle↗
PubMedDate not supplied

Nodular intracerebral leukemic involvement in the course of acute nonlymphocytic leukemia. Case report and review of the literature.

A case of intracerebral nodular leukemic involvement arising during acute nonlymphocytic leukemia (ANLL)-M3 in complete remission is reported. Cerebrospinal fluid examination was normal. Computed tomography (CT) of the brain was consistent with nodular leukemic deposits. Cranial irradiation and intrathecal chemotherapy induced a complete resolution of the lesions. Twenty cases of nodular intracerebral leukemic involvement in ANLL are reviewed. About half of the patients with central nervous system (CNS) leukemia, when submitted systematically to neuroradiological investigations, presented intracerebral solid deposits. The value of CT scan is emphasized.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

[Later revision of patients hospitalized with viral acute hepatitis (author's transl)].

Patients with previous type A hepatitis have not sequelae; but these are frequent and significant in forms of hepatitis B and non B. Reported data concern ambulatory revision since one to twelve years later of 78 patients hospitalized in the acute stage of illness by the Division of Medicine of the Fiorenzuola d'Arda Hospital.

Acute Disease↗
PubMedDate not supplied

[Epidemiological aspects of the hospitalized patients with acute viral hepatitis (author's transl)].

The Authors propose epidemiological studies on 179 patients hospitalized for viral hepatitis in the Department of Medicine of Fiorenzuola D'Arda Hospital from 1966 to 1977. The Authors prove, besides, the worrying incidence of disease and locate two zones of different frequency of hepatitis in the considered territory; they advise any possible causes of thys; they put forward any proposals about the control of disease.

Adolescent↗
PubMedDate not supplied

Diagnostic imaging of primary hepatic leiomyosarcoma: a case report.

Primary hepatic leiomyosarcoma is a very rare tumour only eighteen cases having been reported in the literature. A new case of this tumour is reported here, in which a complete diagnostic imaging work-up was performed, leading to the pathologic diagnosis, obtained with ultrasonically-guided coarse needle biopsy. Transarterial chemoembolisation, a new therapeutic option for this disease, was attempted without success.

Biopsy↗
PubMedDate not supplied

Percutaneous radiofrequency interstitial thermal ablation in the treatment of small hepatocellular carcinoma.

PURPOSE: Very few patients affected by hepatocellular carcinoma can undergo surgery, though it is considered the only curative therapy. We evaluated minimally invasive, percutaneous radiofrequency interstitial thermal ablation for treatment of patients with hepatocellular carcinoma who had no surgical prospects. PATIENTS AND METHODS: Twenty-four patients (16 men and 8 women; age range, 53 to 79 years) with 25 hepatocellular carcinoma nodules of not more than 3.0-cm diameter underwent radiofrequency interstitial thermal ablation treatment with the intent to achieve a cure. In each patient, the thermal necrosis volume achieved was about double the tumor volume. RESULTS: At the end of treatment, destruction of the tumor was achieved in all but two cases in which further thermal lesions were needed. During the mean follow-up interval of 24.8 months (range, 6-64), 13 of 24 patients had recurrences, 9 of whom underwent further radiofrequency thermal ablation treatment. Radiofrequency thermal ablation was again repeated in two patients who showed a second recurrence. A total of 36 hepatocellular carcinoma nodules in 24 patients were treated. No complications were observed. Seven patients died: three due to hepatic failure with advanced cancer, three due to heart failure, and one due to pneumonia. Cumulative survival curves indicated that the median survival time was 44 months and survival rate was 0.95 the first year, 0.84 the second year, 0.67 the third year, and 0.45 the fourth and fifth years. CONCLUSIONS: Percutaneous radiofrequency thermal ablation can be considered a useful new treatment for small hepatocellular carcinoma in patients without surgical prospects. It is simple, effective, and safe, and can be repeated in case of recurrence.

Aged↗