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Biomedical subjects

L Busto Castañón

Publications and source records attributed to L Busto Castañón.

At least 19 recordsLinked to original sources
PubMed2002

[Typical renal metanephric adenoma. Conservative surgery].

Metanephric Adenoma is uncommon renal tumor included in the complex group of the embryologics or nefroblastics renal tumors. Generally occurs in young females and usually has excellent prognosis. It's important to differentiate of malignant variants, particularly renal cell papillary carcinoma, metanephric adenosarcoma and adult Wilms tumor. The suspicion and intraoperative analysis of the tumor can to facilitate the use of conservative renal surgery in order to avoid unnecessary radical and aggressive surgery. To exist cases of metastatic metanephric adenoma, and the totally benign characteristic of the metanephric adenoma and the malignant potential isn't totally clarify.

Adenoma↗
PubMed1998

[Mucinous adenocarcinoma of the urachus synchronic with colorectal adenocarcinoma. Value of immunohistochemistry in the differential diagnosis].

The coincidence of an urachal adenocarcinoma with another similar tumour in other location makes necessary to separate a true primary from a metastatic adenocarcinoma. We report the case of a 66-years-old-man with an urachal mucinous adenocarcinoma and two colonic adenocarcinoma excised in the same surgical act, showing both macro and microscopic studies together with immunohistochemical techniques, that were useful to differentiate the origin of both neoplasms. Among them, the antibody to keratin 7, a cytoplasmic epithelial protein, was positive in the urachal and negative in the colonic tumour.

Adenocarcinoma↗
PubMed1995

[Sarcoidosis and urolithiasis].

OBJECTIVES: A retrospective study of patients with sarcoidosis and urinary lithiasis or lithogenic risk factors (hypercalcemia and hypercalciuria) was conducted to determine the degree of relationship of this disease with urinary lithogenesis. METHODS: From 1978 to 1993, 96 patients with sarcoidosis (68 females and 28 males), aged 17 to 77 years (mean 43 yrs), were evaluated. Serum and 24-hour urinary calcium were determined by the cresolphthalein complexone procedure. The presence of urinary lithiasis was determined from patient clinical data and/or the findings of the imaging techniques that had been utilized to evaluate these patients. RESULTS: 6.3% were hypercalcemic, 26.6% were hypercalciuric, 6.2% had a previous history of urolithiasis and 8.3% had a urinary calculus at the initial consultation. CONCLUSIONS: Hypercalciuria was present in about 25% of the patients with sarcoidosis, whereas approximately 15% had clinically documented urinary lithiasis.

Adolescent↗
PubMed1994

[Primary renal lymphoma in an HIV-positive patient].

We report on an HIV positive patient with bilateral primary renal non-Hodgkin lymphoma that remitted with chemotherapy. The clinical and radiological features, which are initially not distinct from those of other tumors in the same site, and the therapeutic possibilities are discussed.

Adult↗
PubMed1992

[Calcified bladder oat cell associated with hypercalcemia and hypophosphoremia].

Description of a 69-year old male patient presenting calcified vesical tumour which, following a pathoanatomical study was shown to be an non-differentiated oat cell carcinoma associated to transitional carcinoma and adenocarcinoma. Biochemically it presented hypercalcemia and hypophosphoremia and the electron microscope study demonstrated the presence of neurosecretion granules. The immunohistochemical techniques were negative for protein S-100 and cytokeratins, but positive for the membrane epithelial antigen and the neuro-specific enolase. The patient was treated by transurethral resection and polychemotherapy, presenting an initially favourable response but dying 18 months later after widespread metastasis. These data are in agreement with those obtained from the literature review carried out with regard to clinical picture, pathoanatomical studies, aggressiveness and overall poor prognosis with this type of tumours. In our view, the tumour's mixed composition supports an origin of pluripotential cell (steam cell). Presence of neuroendocrine syndromes associated to oat cell vesical tumours is an unusual fact related to the tumour's hormonal secretion.

Adenocarcinoma↗
PubMedDate not supplied

[Evidence for autosomal dominant inheritance through the maternal line in a case of primary ciliary diskinesia].

An atypical case of primary ciliary dyskinesia is presented in which the inheritance, rather than the classical autosomal recessive, appears to be transmitted as an autosomal dominant trait through the maternal line. The case involves two brothers of 29 and 30 years of age, married without children, with a history of infertility, frequent episodes of sinusitis, and recurrent pulmonary infections. Their mother and sister have chronic bronchopathy of unknown etiology. Their father is healthy without pulmonary problems or sinusitis. At physical exam, both brothers, sister and mother presented with bronchial rhonchi at lung auscultation. Blood analysis and pulmonary function, liver and renal tests were all normal. The ultraestructual study of the sperm flagellum by electron microscopy revealed that both brothers have the same anomaly. Namely, in the majority of the cross-sections, both dynein arms are missing. The nexin filament was present, as well as the radial spokes and the central pair of microtubules. In some sperm, besides the absence of dynein arms, there was also absence of the central pair of microtubules. Neither anomalies of the fibrous sheath nor of the dense fibers were found. In approximately 50% of the spermatozoa, the midpiece had a decreased number of mitochondria and extra non-aligned mitochondria. Other findings included extra peripheral microtubules in the axoneme.

Adult↗
PubMedDate not supplied

[Expression of epidermal growth factor receptor and p53 protein in superficial cancer of the urinary bladder].

OBJECTIVE: To determine the relationship of the immunohistochemical expression of p53 and EGF-r (epidermal growth factor receptor) and the recurrence rate and disease-free interval in superficial bladder cancer. METHODS: 144 patients with superficial transitional cell carcinoma of the bladder were studied over a period of three years. Direct dilution anti-EGF-r monoclonal antibody (Biogenex, San Ramon, CA 94583, USA) was utilized for EGF-r determination. Anti-p53 mouse monoclonal antibody (DO7, Novocastra, Newcastle, 24 Claremont Place, UK) at a concentration of 1:100 was utilized for protein p53 determination and was considered negative if less than 10% of the tumor cells were stained and positive if 10% to 100% of the cells stained. EGF-r was determined only as either positive or negative regardless of percent of expression. RESULTS: 55 patients (38%) showed EGF-r and 14 (9.7%) showed p53 expression. The disease free survival was 54.08 months in the patients that showed EGF-r expression vs 30 months for those that did not, the difference being statistically significant (p = 0.027). However, no differences were found in this regard for p53 expression. Tumors that expressed EGF-r recurred in the same site as that of the primary tumor. By contrast, those that did not express EGF-r recurred in another or in multiple sites. CONCLUSIONS: The risk of recurrence is lower in bladder tumors that express EGF-r than those that do not, and when they recur, this generally occurs in the same site as the primary tumor. However, determination of p53 expression was not useful in determining the risk of recurrence or progression of superficial bladder tumors.

Adult↗
PubMedDate not supplied

[Endoscopic cervicotomy in post-prostatectomy sclerosis of the bladder neck].

We treated 23 patients with bladder neck sclerosis following treatment of prostatic adenoma by TUR (20 patients, 87%) and adenomectomy (3 patients, 14%). All patients entered a protocol for bilateral longitudinal bladder neck incision (cervicotomy) and injection of orgotein in the area of incision. Of these, 21 patients were evaluable; 18 (85%) had no recurrence, symptoms remained unchanged without ring in 2 (10%) and there was 1 (5%) recurrence. The results achieved by this simple technique combined with local antiinflammatory therapy make it the treatment of choice for this pathological condition.

Aged↗
PubMedDate not supplied

[Transitional cell carcinoma of the prostate. Report of 2 cases].

Prostate T.C.T. is a rare tumour representing about 1% of all prostate tumours. Out of 435 patients diagnosed in our prostate cancer service between 1975 and 1988, only 2 presented the features of transitional carcinoma of prostatic ductus coexisting in both cases with a glandular type tumour (0.45%). Both cases were treated in a palliative way through R.T.U. and hormonotherapy, also performing in one case telecobalto-therapy. The two cases presented had a very poor evolution, and die 6 month after diagnosis due to tumoral progression with a widespread bone metastasis, blastic in one case and mixed in the other one.

Aged↗
PubMedDate not supplied

[Extravesical ureteral ectopy: report of 2 cases].

Two cases are presented in different sexes of an extravesical, ureteral ectopia, one of which was associated with a cryptorchid U.V.R. and micropenis and the other with complete, bilateral duplicity of the tracts. The authors comment upon the clinical peculiarities in both sexes, as well as the surgical possibilities in each case, with special emphasis on the etiopathogenic and diagnostic problems involved in this type of malformation.

Abnormalities, Multiple↗
PubMedDate not supplied

[Vesico-ureteral reflex. Medical treatment].

We have reviewed the problem of vesico-ureteral reflux in children and comment upon the selection guidelines followed for indicating medical treatment, on the basis of the clinical picture and the radiographic and analytical findings. We assess the results obtained (58.06% of cures) as a result of which we stress the need for conservative treatment in cases of moderate refluxes.

Child↗