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Biomedical subjects

L C Chu

Publications and source records attributed to L C Chu.

6 recordsLinked to original sources
PubMed1992

Consensus at zero acquaintance: replication, behavioral cues, and stability.

That observers tend to agree in their ratings of a target even if they have never interacted with that target has been called consensus at zero acquaintance. The basic finding that consensus is highest for judgments concerning a target's degree of extraversion (EV) and somewhat weaker for judgments of conscientiousness is replicated. Several potential observable cues that might be used by judges when rating targets are examined. The finding that ratings of physical attractiveness correlate with judgments of EV is replicated. In Study 1, rapid body movements and smiling were also found to correlate with EV judgments. The level of consensus declined when initially unacquainted Ss interacted one-on-one (Study 2), but did not decline--and even increased--when Ss interacted in a group (Study 3). Ss judged as extraverted at zero acquaintance were also seen as extraverted after interacting with others.

Adult↗
PubMed1979

Determination of submicrogram quantities of clonidine in biological fluids.

A sensitive and specific GLC method using electron-capture detection was developed for clonidine in plasma and urine. Di-perfluoroacyl derivatives of both clonidine and the 4-methyl analog of clonidine (used as an internal standard) were formed, and an extraction process was developed for the removal of excess derivatization reagent and endogenous biological compounds; the assay permitted quantification of 25 pg of clonidine/ml in a 4-ml plasma sample. The assay was used to elucidate the time course of plasma concentrations in a normotensive subject following oral administration of 50, 100, and 200 microgram of clonidine hydrochloride and also to determine unchanged drug excreted in the urine.

Chromatography, Gas↗
PubMed1976

Subnanogram assay for pilocarpine in biological fluids.

A method for the determination of pilocarpine was developed in which the imidazole ring of pilocarpine was acylated with heptafluorobutyric anhydride, using triethylamine as a catalyst. After cleanup, the pilocarpine derivative was analyzed using GLC with electron-capture detection. The limit of sensitivity was 25-50 pg of pilocarpine, which had been subjected to the derivatization and cleanup procedures. The method was specific for pilocarpine, with the isopilocarpine derivative eluting prior to the pilocarpine derivative.

Animals↗
PubMed1975

Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate.

The in vitro destruction of tumor cells by specifically sensitized mouse lymphocytes was inhibited by adenosine; this inhibition was markedly potentiated by the presence of an inhibitor of adenosine deaminase. The inhibition of cytolysis by adenosine was accompanied by a rapid elevation in lymphocytic adenosine 3',5'-monophosphate (cyclic AMP) concentrations. Both the inhibition of cytolysis and the elevation of cyclic AMP were reversed by prolonged incubation of the lymphocytes in the presence of adenosine or, more rapidly, by removal of the adenosine. Low concentrations of adenosine also caused an elevation of cyclic AMP in human lymphocytes, and this effect of adenosine may contribute to the lack of immune response associated with adenosine deaminase deficiency.

Adenosine↗