PubMed Health⌕ Search

Biomedical subjects

L C Gupta

Publications and source records attributed to L C Gupta.

14 recordsLinked to original sources
PubMed2004

Mg2+: a potent inhibitor of collagen-induced in vitro mineralization.

At physiological concentrations, Mg2+ has been found to be a potent inhibitor of collagen-induced in vitro mineralization. Mg2+ inhibits mineralization by competing with Ca2+ for specific phosphate independent Ca2+ binding sites of the catalytic matrix. Matrix bound Mg2+ subsequently reacts with HPO4(2-) to form MgHPO4 complex which can not be further converted to the matrix bound mineral phase. The matrix, as well as the mineral phase associated with the matrix, influence the rate of mineralization.

Animals↗
PubMed1988

Jaccoud's arthropathy--diagnostic and therapeutic implications.

A case of isolated chronic severe aortic regurgitation with Jaccoud's arthropathy involving the foot is presented. The interesting feature of the case is the absence of history of acute rheumatic arthritis at any stage of the illness. The diagnostic and possible therapeutic significance of this otherwise uncommon and benign condition are discussed.

Adult↗
PubMedDate not supplied

Acute effect of ethanol administration on platelet function.

The acute effect of single dose of ethanol (1.5 g kg) and aspirin (10 mg/kg) alone and in combination, on platelet aggregation time and platelet adhesiveness were studied in rabbits. There was a significant and comparable increase in aggregation time both by aspirin and ethanol. Similarly platelet adhesiveness was decreased by both the agents.

Animals↗
PubMedDate not supplied

Status of platelet functions in volunteers of various blood groups: effect of aspirin.

Platelet functions (platelet aggregation and adhesiveness) were studied in volunteers of different blood groups. The platelet aggregation time was found to be significantly (P less than 0.01) more in blood group O as compared A, B and AB blood groups. Similarly, platelet adhesive index was higher in A, B and AB blood groups when compared to that of blood group O. The administration of a single dose of aspirin (4 mg/kg, po) increased the platelet aggregation time and reduced the platelet adhesive index in all the blood groups.

Aspirin↗
PubMedDate not supplied

Enhanced platelet aggregation by oral contraceptives: effect of PG synthetase inhibitors.

Platelet aggregation time was significantly (P less than 0.01) decreased in female rabbits treated with oral contraceptive (a preparation containing low dose of estrogen) as also by injection of diethylstilbestrol (10 mg/kg), while in animals that received indomethacin (10 mg/kg) or aspirin (30 mg/kg) (PG synthetase inhibitors) along with oral contraceptives or diethylstilbestrol there was no significant alteration in platelet aggregation time. The increased synthesis of prostaglandins or some of the intermediary product like TXA2 might be responsible for this effect.

Animals↗