Low- versus high-dose interferon alfa-2a in relapsed indolent non-Hodgkin's lymphoma.
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
L C Hartmann
Publications and source records attributed to L C Hartmann.
Biological response modifiers in the management of patients with breast cancer.
Despite impressive progress in understanding the biology of breast cancer, mechanisms of host defense, and the pathophysiology of the metastatic process, this burgeoning fact bank has made little impact on the management of patients with breast cancer. There are many interesting ideas for improved diagnosis and therapy in various stages of development, but few have actually translated into improved survival of patients with breast cancer. Potentially useful biological agents include cytokines, monoclonal antibodies, immunotoxins, vaccines, and adoptive cellular therapies. Therapies targetting growth factor receptors and the cellular machinery required for metastasis may become useful, especially when used in combination with other cytotoxic agents. Colony-stimulating factors may allow a test of the hypothesis that augmented dose-intensity of cytotoxic chemotherapy will cure more patients. Though we are not yet sure precisely how to use all of these new tools, there can be little doubt that their application will make a significant impact on the management of patients with breast cancer and other malignancies in the next decade.
Biological Products↗
Group B streptococcal polyarthritis complicating hemophilia B.
We report a case of polyarticular group B streptococcal infection in an HIV-negative 46-year-old alcoholic with factor IX deficiency. Septic arthritis occurs infrequently in the hemophilic population despite their chronic joint disease; indications for diagnostic arthrocentesis in these individuals are discussed. The group B streptococcus often behaves as an opportunist in adults.
Alcoholism↗
Life-threatening bleomycin pulmonary toxicity with ultimate reversibility.
A 60-year-old man with advanced seminoma was treated with four cycles of a cisplatin, etoposide and bleomycin. He then developed severe pulmonary toxicity with diffuse infiltrates as evidenced on a chest x-ray film. The room air PaO2 value was 32 mm Hg. The patient was treated with steroids and oxygen supplementation, including a high FIo2 for several days, and survived and eventually experienced marked improvement in his pulmonary status. Aggressive management of severe bleomycin-induced pneumonitis appears justified.
Antineoplastic Combined Chemotherapy Protocols↗
Breast cancer.
Numerous important issues in breast cancer were debated this past year. Several examples include: the role of screening mammography in women aged 40-49, the management of carcinoma in situ, adjuvant chemotherapy for postmenopausal node-positive women, adjuvant therapy for node-negative women, the primary management of elderly women with breast cancer, the use of a composite of prognostic factors for better predictive power and measures to improve the therapeutic index of the anthracyclines.
Antineoplastic Agents↗
Use of prophylactic antibiotics for prevention of intravascular catheter-related infections in interleukin-2-treated patients.
Explore the source record for details and available documents.
Adult↗
Blue nevus and nevus of Ota associated with dural melanoma.
A 41-year-old woman with a complex congenital nevus that possessed features of both a blue nevus and a nevus of Ota is described. She was found to have melanotic hyperpigmentation of the underlying subcutaneous tissue and dura mater. Two separate melanomas developed in the tissues underlying her nevus (one in the subcutaneous tissue and another intracranially, arising from the dura).
Adult↗
Hypothyroidism after interleukin-2 therapy.
Explore the source record for details and available documents.
Carcinoma, Renal Cell↗