Biomedical subjects

L C Iorio

Publications and source records attributed to L C Iorio.

51 records · Page 3Linked to original sources

PubMed1976

Combinations of selected CNS depressants with d-amphetamine or mazindol on food intake and motor activity of rats.

Amobarbital, diazepam, prochlorperazine and thioridazine were tested alone and in combination with d-amphetamine or mazindol on food consumption and spontaneous motor activity in rats. Of the four depressants tested (1) only amobarbital enhanced the anorexic effects of d-amphetamine and (2) amobarbital, diazepam and prochlorperazine enhanced the hypermotility induced by d-amphetamine. None of the depressants altered the anorexic effect of mazindol but amobarbital and diazepam decreased and prochlorperazine increased the hypermotility induced by mazindol. These differential effects of the CNS depressants suggest that d-amphetamine and mazindol might have different mechanisms of anorexiant or stimulatory action. The data also suggest that, to achieve anorexia with diminished CNS stimulation, combinations of d-amphetamine and any of the tested CNS depressants seem to be precluded. In fact, this desired clinical objective might be achieved with combinations of mazindol and either amobarbital or diazepam.

Amobarbital↗

PubMed1976

Synthesis and central nervous system depressant activity of some bicyclic amides.

A series of aryl bicyclic analogs of succinimide and glutarimide was prepared and evaluated for CNS depressant activity. The 8a-aryl-3,4,6,7,8,8a-hexahydro-2H-pyrrolo[2,1-beta][1,3]oxazin-6-ones possessed the best overall spectrum of activity relative to the standard agents glutethimide and phenobarbital.

Amides↗

PubMed1975

Synthesis and biological evaluation of some 10-substituted 2,3-dihydroimidazo[2,1-b]quinazolin-5(10H)-ones, a new class of bronchodilators.

On treatment of N-substituted isatoic anhydrides with 2-methylmercaptoimidazolines, 10-substituted imidazo[2,1-b]quinazolin-5(10H)-ones are obtained. Several members of this class exhibited pronounced broncholytic activity. The structure-activity relationships (based on results obtained in the guinea pig histamine aerosol test) of these nonsympathomimetic bronchodilators are discussed. In addition, the detailed pharmacological evaluation of two analogs found to be five to ten times more active than theophyline as bronchodilators without having central nervous system or cardiovascular side effects is described.

Animals↗

PubMed1975

Blockade by narcotic drugs of naloxone-precipitated jumping in morphine-dependent mice.

A dose regimen for administration of morphine, test drugs with potential to cause physical dependence and naloxone was determined to allow within one experimental day acquisition of morphine-dependent mice and evaluation of the narcotic drugs for their ability to prevent naloxone-precipitated jumping. This test procedure can be used to assess capacity of unknown drugs to suppress morphine withdrawal symptoms; the mechanism of suppression can be subsequently determined in secondary tests. However, for known morphine-like analgesics, the test procedure appears to reliably assess physical dependence properties. The results obtained on subcutaneous administration of five selected narcotic drugs and apomorphine show that their order of potency was methadone greater than meperidine equal apomorphine greater than d-propoxyphene greater than pentazocine. Codeine, also tested subcutaneously, did not substitute at sublethal doses. Except for apomorphine, which might have masked naloxone-precipitated jumping by inducing behavioral aggression, the order of potency compares favorably with the degree of physical dependence reported in humans. Thus, the described procedure might be employed to evaluate morphine substitution and hence potential physical dependence liability of unknown narcotic-like analgesics.

Administration, Oral↗

PubMed1975

Pharmacological analysis of a new anorexic substance: 5-hydroxy-5(4'-chlorophenyl)-2, 3-dihydro-5H-imidazo-(2, 1-a) isoindole (Mazindol).

5-Hydroxy-5-(4'-chlorophenyl-2, 3-dihydro-5H-imidazo (2, 1-a)isoindole (mazindol), a novel tricyclic compound, has been shown to suppress food consumption in rats at doses causing weak central stimulation and little effects on blood pressure or heart rate. The substance produces dose-related decreases in the consumption of orange juice in cebus monkeys trained on an operant behavior schedule. The compound did not alter cardiac or pulmonary hemodynamics in the anesthetized dog but provided potentiation of norepinephrine pressor responses. Mazindol also demonstrated potent but incomplete antagonism of reserpine-induced hypothermia in mice, antagonism of tetrabenazine catalepsy in rats, and suppression of mouse-killing behavior of rats. Suppression of mouse-killing was reduced by lesions placed in the septal area of the brain. Brain monoamine oxidase or catechol-o-methyl-transferase activities were not altered, although preliminary experiments showed that mazindol reduced uptake of norepinephrine in brain tissue.

Aggression↗

PubMed1973