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Biomedical subjects

L C Mims

Publications and source records attributed to L C Mims.

At least 19 recordsLinked to original sources
PubMed1979

Cold stress influence on lung lecithin in the newborn rabbit.

Term, food-water deprived newborn rabbits exposed to a cold environment for 48 h demonstrated a significant decrease in total lung lipid (p less than 0.01), total triglyceride (p less than 0.001), total phospholipid (p less than 0.05), and total phosphatidylcholine (p less than 0.025). Disaturated phosphatidylcholine remained unchanged. Fatty acid methyl esters of total and disaturated phosphatidylcholine were not influenced by cold stress. Likewise, there was no alteration in pulmonary function as determined by deflation pressure-volume relationships.

Animals↗
PubMed1979

Adaptive gluconeogenesis in preterm and term rabbits.

UNLABELLED: Carbohydrate metabolism in the developing rabbit was investigated for deficiencies that may be responsible for the failure of many preterm (28 1/2--29 1/2 day) animals to survive the first hours of life. The preterm animal shows an inability to reverse glycogenolysis or initiate gluconeogenesis from lactate or alanine in the first hours of life. This impairment, coupled with 50% less liver glycogen stores than the term animal, places the preterm animal at jeopardy for energy substrate early on in life. Unexpected was the early, rapid conversion of glycerol to glucose by the preterm animal. This ability seemed to be the primary difference in carbohydrate metabolism between the surviving and nonsurviving preterm rabbit. SPECULATION: Impaired glyconeogenesis from lactate and alanine in the preterm animal coupled with active gluconeogenesis from glycerol suggests that substrates from lipolysis may be very important for early adaptation. Preterm animals endowed with limited fat stores, thus, minimal available glycerol, would be incapable of survival.

Animals↗
PubMed1978

Gastric response in low birth weight infants fed various formulas.

Feeding techniques, delayed gastric emptying, volume overload, or reverse peristalsis may lead to regurgitation and aspiration in the premature infant. Noting these complications, various aspects of gastric function were studied in relation to the type of formula fed. 27 low birth weight infants (less than 2,000 g) were each fed one of three randomly assigned commercial formulas, which varied in osmolarity and MCT content. Gastric pH and emptying were monitored during the first 48 h of life. The fatty acid chain length of the triglyceride in the formula apparently did not influence either gastric pH or emptying. Infants fed formulas having a higher osmolar load (539 mosm/1) and containing protein hydrolysate showed greater gastric retention.

Dietary Carbohydrates↗
PubMed1976

The analysis of the molecular species of fetal rabbit lung phosphatidylcholine by consecutive chromatographic techniques.

The major molecular species of pulmonary phosphatidylcholine in the fetal rabbit were analyzed as the diacylglycerol acetate derivatives. After fractionation by Ag+ thin-layer chromatography according to the degree of unsaturation, the intact diacylglycerol acetates were analyzed by gas-liquid chromatography to obtain the carbon number composition. The methyl esters of these acetates were used to obtain the fatty acid profiles. The composition of the molecular species was derived from these sets of data. The proportions of 16 : 0/16 : 0, 14: 0/16 : 0 and 16 : 0/16 : 1 increased with gestation, while 16 : 0/18 : 1 decreased. The concentration of 16 : 0/16 : 0 increased about 50% the last two days of gestation while 16 : 0/16 : 1 increased about 300%. The possibility that 16 : 0/16 : 1 is a precursor of 16 : 0/16 : 0 via biohydrogenation is discussed.

Animals↗
PubMed1976

Riboflaven and bilirubin response during phototherapy.

Twenty-four jaundiced neonates were studied, 12 in the treatment group and 12 in the untreated group. Patients were randomly selected to receive oral riboflavin. The mean 24-hr bilirubin decrease was determined during phototherapy. Blue light (420-470 nm) energy ranged from 6-10 muW/cm2. The observed 24-hr bilirubin decreased was compared with the expected decrease based on an energy-dose-response relationship. Riboflavin-treated infants received either 6-7 mu W/cm blue light energy or 810 muW/cm (same as control group). Those infants receiving less energy than the control group (8-10 muW)cm2 had a mean 24-hr bilirubin decrease (3.05 mg/100 ml/24 hr) equal to the control group (3.09 mg/100 ml/24 hr). Those riboflavin-treated infants receiving energy equal to the control group showed a greater decline (5.2 mg/100 ml/24 hr) in their mean 24-hr bilirubin. Although effective, additional in vivo studies are required to clarify the full effects, especially on DNA, of using photosensitizers such as riboflavin in the presence of bilirubin and blue light energy (420-470 nm).

Bilirubin↗
PubMed1975

A new model for neonatal pulmonary hemorrhage research.

Hemorrhagic atelectasis was successfully produced in newborn rabbits by pharmacologically narrowing airways leading to alveoli ventilated with oxygen-enriched gas. Between 48% and 62% of alveoli filled with blood cells. Areas of lung with a tendency to collapse were measured by pressure volume studies. Animals given supplemental oxygen retained 56% of total lung volume compared with 79% in the pilocarpine group, which suggested increased effectiveness of anti-atelectasis factors in the latter. Less total lung gas was present in the pilocarpine group (4.0 plus or minus 0.4 cc/g) compared with oxygen controls (5.1 plus or minus 0.81 cc/g), which indicated more noninflatable lung. Neither surfactant deficiency nor heart failure needed to be present for pulmonary hemorrhage to occur.

Animals↗
PubMed1975

The significance of circulating glycerol as a precursor of pulmonary phosphatidylcholine in the developing mammalian lung.

There is scant information regarding the contribution made by circulating precursors to pulmonary phosphatidylcholine synthesis in the developing mammalian lung. In situ pulmonary artery perfusions were performed in term New Zealand newborn rabbits with physiologic buffer containing either 3.6 mM or 10.8 mM glycerol. There was a twofold increase in nanomoles of glycerol-phosphatidylcholine synthesized at 30 min when the higher concentration of glycerol was used. Continuing with the higher concentration, a near three-fold increase was observed between the 30-min and 60-min perfusions. This data indicates that the de novo synthesis of pulmonary phosphatidylcholine is influenced by the concentration of glycerol in the perfusate as well as the duration of perfusion.

Animals↗
PubMed1969

Neonatal therapeutics.

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Drug-Related Side Effects and Adverse Reactions↗