Congenital sensory neuropathy with anhidrosis.
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Child↗
Biomedical subjects
L C Thakur
Publications and source records attributed to L C Thakur.
Influence of type I and type II diabetes mellitus on phenytoin steady-state levels.
Phenytoin kinetics was studied in male type I and type II diabetic patients, ten in each group. Age and sex matched epileptic patients receiving phenytoin alone served as control groups. Steady-state concentration of phenytoin was significantly lower in both types of diabetics compared to respective controls. The Vmax and Vmax/Km of phenytoin were significantly increased in type I diabetics. The Vmax was unaltered in type II diabetics but the Vmax/Km was higher in them. Protein binding of the drug was decreased in both groups. It is concluded that phenytoin kinetics is increased in both types of diabetics which may be responsible for the lower steady-state concentration of the drug.
Adult↗
Cryptogenic chorea.
A total of 40 cases of cryptogenic chorea were studied over a period of 4 years in JIPMER Hospital which serves the population of Pondicherry and adjoining regions of South India. Analysis of our cases showed the highest incidence for the 10-15 year age group with no sex predilection. Arthralgia and non-specific fever preceded the onset of chorea in most patients. The majority had generalized chorea of variable severity. Laboratory evidence of rheumatic fever was absent in all cases. The socioeconomic, environmental and cultural factors contributing to persistently high rate of infections together with the absence of evidence of a rheumatic process indicate a non-rheumatic aetiology.
Adolescent↗
Cysticercosis in South India.
A total of 38 cases of human cysticercosis were diagnosed by histopathological examination within a period of 10 years in JIPMER Hospital which serves the population of Pondicherry and adjoining regions of South India. Analysis of our cases showed that there was no sex predilection and 34 of the 38 cases were within the first three decades of life. A curious yet striking feature was that in 37 of the 38 cases the lesions were localized above the level of the umbilicus. Lesions of the subcutaneous tissue formed the largest group with 18 cases. Seventeen of the 38 cases were confined to the eyes, forming the largest series to be reported from India. In six cases there was evidence of brain involvement with postmortem confirmation in three. The JIPMER Hospital records showed a high incidence of epilepsy in this region with a ratio of one out of every four patients attending the neurology clinic. As cerebral cysticercosis is a known cause of epileptiform convulsions, it is suggested that many cases of epilepsy may in fact be due to cerebral cysticercosis. The majority of our patients were drawn from the rural population. We analysed the social customs and related factors which are peculiar to this region and were indirectly responsible for the high incidence of cysticercosis.
Adolescent↗
Alphamethyldopa analgesia: its possible mechanism of action.
The analgesic activity of alphamethyldopa (MD) was studied in mice using the acetic acid writhing test and the hot plate method. In the writhing test, MD produced a dose-dependent analgesic effect with an ED 50 of 26.5 mg/kg. The results of the hot plate test confirmed the analgesic activity of MD. Yohimbine, but not naloxone, antagonized the analgesic effect of MD in the writhing test. Atropine antagonized MD analgesia while physostigmine potentiated it. The study suggests that MD analgesia is of the nonopioid type involving both adrenergic and cholinergic systems.
Analgesics↗
Effects of blood levels of tetracycline and oxytetracycline on hepatic and renal functions in normal subjects.
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Administration, Oral↗
Childhood neurocysticercosis in south India.
A total of 21 cases of childhood neurocysticercosis seen over five years (1985-89) at JIPMER hospital Pondicherry, are reported. Nine of these patients were males and twelve females. Their age ranged between 5 to 15 years. The presenting features were convulsive seizures (14), features of raised intracranial pressure (6) and meningoencephalitis syndrome (1). Diagnosis of neurocysticercosis was based on positive CSF serological tests (11), CT morphology (11), brain biopsy (1) and autopsy (1). Praziquantel therapy was given in 4 cases, 3 of them showed remarkable improvement in neurological status and one died of acute reaction.
Adolescent↗